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• Observation of metastable Abeta amyloid protofibrils by atomic force microscopy.
• Citation:
  Harper J, Wong S, Lieber C, Lansbury P
  

  Observation of metastable Abeta amyloid protofibrils by atomic force microscopy.

  Chemistry & biology. 1997 Feb;4(2):119-25
  [PubMed] [Alzforum]
• Supporting:
  • Soluble oligomers of Aβ are neurotoxic in vitro and in vivo.

    SHOW Details   Supporting(8)   Consistent(1) 

    Experimental Approach: Pathophysiology,   Mechanism - biochemistry and structural biology,  
    Pathogenic Narrative Tags: Pathogenic event
    Supporting Evidence
    

    • Walsh D, Lomakin A, Benedek G, Condron M, Teplow D
      Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.
      The Journal of biological chemistry. 1997 Aug 29;272(35):22364-72
    • Harper J, Wong S, Lieber C, Lansbury P
      Observation of metastable Abeta amyloid protofibrils by atomic force microscopy.
      Chemistry & biology. 1997 Feb;4(2):119-25
    • Nilsberth C, Westlind-Danielsson A, Eckman C, Condron M, Axelman K, Forsell C, Stenh C, Luthman J, Teplow D, Younkin S, Näslund J, Lannfelt L
      The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.
      Nature neuroscience. 2001 Sep;4(9):887-93
    • Oda T, Wals P, Osterburg H, Johnson S, Pasinetti G, Morgan T, Rozovsky I, Stine W, Snyder S, Holzman T
      Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress.
      Experimental neurology. 1995 Nov;136(1):22-31
    • Hartley D, Walsh D, Ye C, Diehl T, Vasquez S, Vassilev P, Teplow D, Selkoe D
      Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.
      The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Oct 15;19(20):8876-84
    • Lambert M, Barlow A, Chromy B, Edwards C, Freed R, Liosatos M, Morgan T, Rozovsky I, Trommer B, Viola K, Wals P, Zhang C, Finch C, Krafft G, Klein W
      Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.
      Proceedings of the National Academy of Sciences of the United States of America. 1998 May 26;95(11):6448-53
    • Walsh D, Hartley D, Kusumoto Y, Fezoui Y, Condron M, Lomakin A, Benedek G, Selkoe D, Teplow D
      Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.
      The Journal of biological chemistry. 1999 Sep 3;274(36):25945-52
    • Walsh D, Klyubin I, Fadeeva J, Cullen W, Anwyl R, Wolfe M, Rowan M, Selkoe D
      Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
      Nature. 2002 Apr 4;416(6880):535-9

    Consistent statements
    

    • Several lines of evidence indicate that smaller Aβ oligomers, rather than full-fledged fibrils, may be the primary neurotoxic form. Tycko R 
  • For self-aggregation to occur in vitro, micromolar Aβ concentrations are required.

    SHOW Details   Supporting(3) 

    Experimental Approach: Mechanism - biochemistry and structural biology,  
    Pathogenic Narrative Tags: Initial condition
    Supporting Evidence
    

    • Lomakin A, Chung D, Benedek G, Kirschner D, Teplow D
      On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants.
      Proceedings of the National Academy of Sciences of the United States of America. 1996 Feb 6;93(3):1125-9
    • Harper J, Lansbury P
      Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins.
      Annual review of biochemistry. 1997;66:385-407
    • Harper J, Wong S, Lieber C, Lansbury P
      Observation of metastable Abeta amyloid protofibrils by atomic force microscopy.
      Chemistry & biology. 1997 Feb;4(2):119-25
• Created On: Wed, Apr 23 06:48:46 EDT 2008
• Last Modified On: Wed Apr 23 06:48:46 EDT 2008