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Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.
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APOE and CLU are both are present in amyloid plaques and can bind Aβ.
SHOW Details
Supporting(4)
Genes/Proteins: (2)
Experimental Approach: Biomarkers, Mechanism - biochemistry and structural biology
Pathogenic Narrative Tags: Pathologic change
Supporting Evidence
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Zlokovic B,
Martel C,
Matsubara E,
McComb J,
Zheng G,
McCluskey R,
Frangione B,
Ghiso J
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.
Proceedings of the National Academy of Sciences of the United States of America. 1996 Apr 30;93(9):4229-34 -
Ghiso J,
Matsubara E,
Koudinov A,
Choi-Miura N,
Tomita M,
Wisniewski T,
Frangione B
The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.
The Biochemical journal. 1993 Jul 1;293 ( Pt 1):27-30 -
Calero M,
Rostagno A,
Matsubara E,
Zlokovic B,
Frangione B,
Ghiso J
Apolipoprotein J (clusterin) and Alzheimer's disease.
Microscopy research and technique. 2000 Aug 15;50(4):305-15 -
May P,
Lampert-Etchells M,
Johnson S,
Poirier J,
Masters J,
Finch C
Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat.
Neuron. 1990 Dec;5(6):831-9
- Protein: Clusterin [Homo sapiens]
- Protein: Apolipoprotein E [Homo sapiens]
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APOE and CLU are the most abundantly expressed apolipoproteins in the central nervous system.
SHOW Details Supporting(5)
Genes/Proteins: (2)
Experimental Approach: Genetics
Pathogenic Narrative Tags: Initial condition
Supporting Evidence
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May P,
Finch C
Sulfated glycoprotein 2: new relationships of this multifunctional protein to neurodegeneration.
Trends in neurosciences. 1992 Oct;15(10):391-6 -
Ghiso J,
Matsubara E,
Koudinov A,
Choi-Miura N,
Tomita M,
Wisniewski T,
Frangione B
The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.
The Biochemical journal. 1993 Jul 1;293 ( Pt 1):27-30 -
Calero M,
Rostagno A,
Matsubara E,
Zlokovic B,
Frangione B,
Ghiso J
Apolipoprotein J (clusterin) and Alzheimer's disease.
Microscopy research and technique. 2000 Aug 15;50(4):305-15 -
Roheim P,
Carey M,
Forte T,
Vega G
Apolipoproteins in human cerebrospinal fluid.
Proceedings of the National Academy of Sciences of the United States of America. 1979 Sep;76(9):4646-9 -
Zlokovic B,
Martel C,
Matsubara E,
McComb J,
Zheng G,
McCluskey R,
Frangione B,
Ghiso J
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.
Proceedings of the National Academy of Sciences of the United States of America. 1996 Apr 30;93(9):4229-34
- Protein: Clusterin [Homo sapiens]
- Protein: Apolipoprotein E [Homo sapiens]
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Besides RAGE, gp330/megalin has also been reported to transport circulating plasma Aβ back into the brain, in a complex with apoJ.
SHOW Details Supporting(1)
Alternative to: (1)
Genes/Proteins: (2)
Experimental Approach: Target validation, Mechanism - physiological systems, Animal modelsGenes/Proteins
Pathogenic Narrative Tags: Initial condition
Supporting Evidence
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Zlokovic B,
Martel C,
Matsubara E,
McComb J,
Zheng G,
McCluskey R,
Frangione B,
Ghiso J
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.
Proceedings of the National Academy of Sciences of the United States of America. 1996 Apr 30;93(9):4229-34
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ADDLs of this mass are too small to contain clusterin (Mr 80,000), indicating a chaperone-like function for clusterin.
Lambert M
Barlow A
Chromy B
Edwards C
Freed R
Liosatos M
Morgan T
Rozovsky I
Trommer B
Viola K
Wals P
Zhang C
Finch C
Krafft G
Klein W
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PubMed
Clusterin is a multifunctional molecule that interacts with the soluble form of Aβ in animal models of AD and binds soluble Aβ in a specific and reversible manner, forming complexes that have been shown to cross the blood-brain barrier.
SHOW Details
Supporting(4)
Genes/Proteins: (1)
Supporting(4)
Genes/Proteins: (1)
Experimental Approach:
Pathogenic Narrative Tags:
Supporting Evidence
Pathogenic Narrative Tags:
Supporting Evidence
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Golabek A,
Marques M,
Lalowski M,
Wisniewski T
Amyloid beta binding proteins in vitro and in normal human cerebrospinal fluid.
Neuroscience letters. 1995 May 19;191(1-2):79-82 -
Ghiso J,
Matsubara E,
Koudinov A,
Choi-Miura N,
Tomita M,
Wisniewski T,
Frangione B
The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.
The Biochemical journal. 1993 Jul 1;293 ( Pt 1):27-30 -
Zlokovic B,
Martel C,
Matsubara E,
McComb J,
Zheng G,
McCluskey R,
Frangione B,
Ghiso J
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.
Proceedings of the National Academy of Sciences of the United States of America. 1996 Apr 30;93(9):4229-34 -
Zlokovic B,
Martel C,
Mackic J,
Matsubara E,
Wisniewski T,
McComb J,
Frangione B,
Ghiso J
Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta.
Biochemical and biophysical research communications. 1994 Dec 15;205(2):1431-7
- Protein: Clusterin [Homo sapiens]
