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Antioxidant therapy in Alzheimer's disease: theory and practice.
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Aging-related changes involving mitochondrial dysfunction are critical to understanding Alzheimer pathobiology and energy homeostasis: with age and diabetes, antioxidant enzymes are diminished and this sets the stage for future disease processes.
SHOW Details
Supporting(11)
Alternative to: (1)
Experimental Approach: Mechanism - physiological systems, Pathophysiology
Pathogenic Narrative Tags: Perturbation
Supporting Evidence
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Aliev G,
Palacios H,
Walrafen B,
Lipsitt A,
Obrenovich M,
Morales L
Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease.
The international journal of biochemistry & cell biology. 2009 Oct;41(10):1989-2004 -
Aliyev A,
Chen S,
Seyidova D,
Smith M,
Perry G,
de la Torre J,
Aliev G
Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease.
Journal of the neurological sciences. 2005 Mar 15;229-230:285-92 -
Vančová O,
Bačiak L,
Kašparová S,
Kucharská J,
Palacios H,
Horecký J,
Aliev G
In vivo and in vitro assessment of brain bioenergetics in aging rats.
Journal of cellular and molecular medicine. 2009 Aug 10; -
Aliev G,
Liu J,
Shenk J,
Fischbach K,
Pacheco G,
Chen S,
Obrenovich M,
Ward W,
Richardson A,
Smith M,
Gasimov E,
Perry G,
Ames B
Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.
Journal of cellular and molecular medicine. 2009 Feb;13(2):320-33 -
Moreira P,
Smith M,
Zhu X,
Honda K,
Lee H,
Aliev G,
Perry G
Oxidative damage and Alzheimer's disease: are antioxidant therapies useful?
Drug news & perspectives. 2005;18(1):13-9 -
Horecký J,
Baciak L,
Kasparová S,
Pacheco G,
Aliev G,
Vancová O
Minimally invasive surgical approach for three-vessel occlusion as a model of vascular dementia in the rat-brain bioenergetics assay.
Journal of the neurological sciences. 2009 Aug 15;283(1-2):178-81 -
Shenk J,
Liu J,
Fischbach K,
Xu K,
Puchowicz M,
Obrenovich M,
Gasimov E,
Alvarez L,
Ames B,
Lamanna J,
Aliev G
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.
Journal of the neurological sciences. 2009 Aug 15;283(1-2):199-206 -
Aliev G,
Obrenovich M,
Reddy V,
Shenk J,
Moreira P,
Nunomura A,
Zhu X,
Smith M,
Perry G
Antioxidant therapy in Alzheimer's disease: theory and practice.
Mini reviews in medicinal chemistry. 2008 Nov;8(13):1395-406 -
Aliev G,
Shenk J,
Fischbach K,
Perry G
Stem cell niches as clinical targets: the future of anti-ischemic therapy?
Nature clinical practice. Cardiovascular medicine. 2008 Sep;5(9):590-1 -
Karaça M,
Kiliç E,
Yazici B,
Demir S,
de la Torre J
Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial.
Neurological research. 2002 Jan;24(1):73-80 -
Zhu X,
Smith M,
Perry G,
Aliev G
Mitochondrial failures in Alzheimer's disease.
American journal of Alzheimer's disease and other dementias. 2004;19(6):345-52
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PubMed
Amyloid deposit in the brain of Alzheimer patients has nothing to do with the treatment or benefit of AD patients.
SHOW Details
Supporting(7)
Inconsistent(1)
Supporting(7)
Inconsistent(1)
Experimental Approach:
Target validation,
Pathophysiology,
Mechanism - biochemistry and structural biology
Pathogenic Narrative Tags: Pathologic change
Supporting Evidence
Pathogenic Narrative Tags: Pathologic change
Supporting Evidence
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Horecký J,
Baciak L,
Kasparová S,
Pacheco G,
Aliev G,
Vancová O
Minimally invasive surgical approach for three-vessel occlusion as a model of vascular dementia in the rat-brain bioenergetics assay.
Journal of the neurological sciences. 2009 Aug 15;283(1-2):178-81 -
Moreira P,
Siedlak S,
Aliev G,
Zhu X,
Cash A,
Smith M,
Perry G
Oxidative stress mechanisms and potential therapeutics in Alzheimer disease.
Journal of neural transmission (Vienna, Austria : 1996). 2005 Jul;112(7):921-32 -
Aliev G,
Obrenovich M,
Seyidova D,
de la Torre J
Exploring ischemia-induced vascular lesions and potential pharmacological intervention strategies.
Histology and histopathology. 2005 Jan;20(1):261-73 -
Aliev G,
Obrenovich M,
Reddy V,
Shenk J,
Moreira P,
Nunomura A,
Zhu X,
Smith M,
Perry G
Antioxidant therapy in Alzheimer's disease: theory and practice.
Mini reviews in medicinal chemistry. 2008 Nov;8(13):1395-406 -
Aliev G,
Palacios H,
Walrafen B,
Lipsitt A,
Obrenovich M,
Morales L
Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease.
The international journal of biochemistry & cell biology. 2009 Oct;41(10):1989-2004 -
de la Torre J,
Aliev G,
Perry G
Drug therapy in Alzheimer's disease.
The New England journal of medicine. 2004 Oct 28;351(18):1911-3; author reply 1911-3 -
Obrenovich M,
Morales L,
Cobb C,
Shenk J,
Méndez G,
Fischbach K,
Smith M,
Qasimov E,
Perry G,
Aliev G
Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation.
Journal of cellular and molecular medicine. 2009 May;13(5):853-65
