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• Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease.
• Citation:
  Counts S, He B, Che S, Ikonomovic M, DeKosky S, Ginsberg S, Mufson E
  

  Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease.

  Archives of neurology. 2007 Dec;64(12):1771-6
  [PubMed] [Alzforum]
• Supporting:
  • Despite evidence that demonstrates that Aβ42 binds to membrane lipids but does not bind to the α7nicotinic acetylcholine receptor, both increases and decreases in α7nAChR number have been reported in AD animal models and human patients, making a stronger case for a relationship between AD pathology and α7nAChR.

    SHOW Details   Supporting(6)   Alternative to: (1)    Genes/Proteins: (2)

    Experimental Approach: Mechanism - biochemistry and structural biology,   Biomarkers,   Mechanism - molecular and cell
    Pathogenic Narrative Tags: Pathogenic event
    Supporting Evidence
    

    • Small D, Maksel D, Kerr M, Ng J, Hou X, Chu C, Mehrani H, Unabia S, Azari M, Loiacono R, Aguilar M, Chebib M
      The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor.
      Journal of neurochemistry. 2007 Jun;101(6):1527-38
    • Counts S, He B, Che S, Ikonomovic M, DeKosky S, Ginsberg S, Mufson E
      Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease.
      Archives of neurology. 2007 Dec;64(12):1771-6
    • Dineley K, Xia X, Bui D, Sweatt J, Zheng H
      Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins.
      The Journal of biological chemistry. 2002 Jun 21;277(25):22768-80
    • Teaktong T, Graham A, Court J, Perry R, Jaros E, Johnson M, Hall R, Perry E
      Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytes.
      Glia. 2003 Jan 15;41(2):207-11
    • Bednar I, Paterson D, Marutle A, Pham T, Svedberg M, Hellström-Lindahl E, Mousavi M, Court J, Morris C, Perry E, Mohammed A, Zhang X, Nordberg A
      Selective nicotinic receptor consequences in APP(SWE) transgenic mice.
      Molecular and cellular neurosciences. 2002 Jun;20(2):354-65
    • Yu W, Guan Z, Bogdanovic N, Nordberg A
      High selective expression of alpha7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer's disease and patients carrying Swedish APP 670/671 mutation: a possible association with neuritic plaques.
      Experimental neurology. 2005 Mar;192(1):215-25

    Alternative statements
    

    • Aβ can alter the activity of a number calcium conducting ion channels such as voltage-gated calcium channels, NMDA receptors and nicotinic receptors. Smith I  Green K  LaFerla F 

    Genes/Proteins
    

    • Protein: Beta-amyloid protein 42 [Homo sapiens]
    • Protein: Neuronal acetylcholine receptor subunit alpha-7 [Homo sapiens]
• Created On: Tue, Jan 26 15:11:03 EST 2010
• Last Modified On: Tue Jan 26 15:11:03 EST 2010