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• Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
• Citation:
  Bertram L, McQueen M, Mullin K, Blacker D, Tanzi R
  

  Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.

  Nature genetics. 2007 Jan;39(1):17-23
  [PubMed] [Alzforum]
• Supporting:
  • Although twin studies suggest that there are several susceptibility genes which, along with the APOE ε4 allele, contribute to up to 80% of late-onset AD (LOAD) cases, discovery of other susceptibility genes has been elusive.

    SHOW Details   Supporting(2)     Genes/Proteins: (1)

    Experimental Approach: Epidemiology,   Genetics,  
    Pathogenic Narrative Tags: Initial condition
    Supporting Evidence
    

    • Gatz M, Reynolds C, Fratiglioni L, Johansson B, Mortimer J, Berg S, Fiske A, Pedersen N
      Role of genes and environments for explaining Alzheimer disease.
      Archives of general psychiatry. 2006 Feb;63(2):168-74
    • Bertram L, McQueen M, Mullin K, Blacker D, Tanzi R
      Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
      Nature genetics. 2007 Jan;39(1):17-23

    Genes/Proteins
    

    • Gene: APOE apolipoprotein E [Homo sapiens]
  • More than 550 other genes have been proposed as candidates for Alzheimer’s disease susceptibility, but thus far none have been confirmed to have a role in Alzheimer’s disease pathogenesis.

    SHOW Details   Supporting(1)     Genes/Proteins: (3)

    Experimental Approach: Genetics,  
    Pathogenic Narrative Tags: Initial condition
    Supporting Evidence
    

    • Bertram L, McQueen M, Mullin K, Blacker D, Tanzi R
      Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
      Nature genetics. 2007 Jan;39(1):17-23

    Genes/Proteins
    

    • Protein: Beta-amyloid protein 42 [Homo sapiens]
    • Protein: Beta-amyloid protein 40 [Homo sapiens]
    • Gene: Cr2 complement receptor 2 [Mus musculus]
• Created On: Tue, May 26 15:33:34 EDT 2009
• Last Modified On: Tue May 26 15:33:34 EDT 2009