AlzSWAN Knowledge Base

Powered by SWAN (Semantic Web Applications in Neuromedicine)

• Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid.
• Citation:
  King M, Kan H, Baas P, Erisir A, Glabe C, Bloom G
  

  Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid.

  The Journal of cell biology. 2006 Nov 20;175(4):541-6
  [PubMed] [Alzforum]
• Supporting:
  • Full-length tau does not aggregate spontaneously in cells, but rather, truncated tau forms intracellular inclusions.

    SHOW Details   Supporting(2)     Genes/Proteins: (1)

    Experimental Approach: Pathophysiology,   Mechanism - biochemistry and structural biology,  
    Pathogenic Narrative Tags: Pathologic change
    Supporting Evidence
    

    • Trinczek B, Biernat J, Baumann K, Mandelkow E, Mandelkow E
      Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules.
      Molecular biology of the cell. 1995 Dec;6(12):1887-902
    • King M, Kan H, Baas P, Erisir A, Glabe C, Bloom G
      Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid.
      The Journal of cell biology. 2006 Nov 20;175(4):541-6

    Genes/Proteins
    

    • Gene: MAPT microtubule-associated protein tau [Homo sapiens]
  • Increased rate and/or state of phosphorylation and various other pathological events, including Aβ-mediated toxicity, as well as oxidative stress and inflammation, trigger or contribute (independently or in combination) to an abnormal detachment of tau from the MTs.

    SHOW Details   Supporting(6)   Consistent(3)   Alternative to: (1)    Genes/Proteins: (1)

    Experimental Approach: Mechanism - molecular and cell,   Mechanism - biochemistry and structural biology,  
    Pathogenic Narrative Tags: Pathogenic event
    Supporting Evidence
    

    • King M, Kan H, Baas P, Erisir A, Glabe C, Bloom G
      Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid.
      The Journal of cell biology. 2006 Nov 20;175(4):541-6
    • Andersen J
      Oxidative stress in neurodegeneration: cause or consequence?
      Nature medicine. 2004 Jul;10 Suppl:S18-25
    • Moreira P, Smith M, Zhu X, Nunomura A, Castellani R, Perry G
      Oxidative stress and neurodegeneration.
      Annals of the New York Academy of Sciences. 2005 Jun;1043:545-52
    • David D, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, Ravid R, Dröse S, Brandt U, Müller W, Eckert A, Götz J
      Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice.
      The Journal of biological chemistry. 2005 Jun 24;280(25):23802-14
    • Liu Q, Lee H, Honda K, Siedlak S, Harris P, Cash A, Zhu X, Avila J, Nunomura A, Takeda A, Smith M, Perry G
      Tau modifiers as therapeutic targets for Alzheimer's disease.
      Biochimica et biophysica acta. 2005 Jan 3;1739(2-3):211-5
    • Rapoport M, Dawson H, Binder L, Vitek M, Ferreira A
      Tau is essential to beta -amyloid-induced neurotoxicity.
      Proceedings of the National Academy of Sciences of the United States of America. 2002 Apr 30;99(9):6364-9

    Consistent statements
    

    • Tau hyperphosphorylation can be induced with stress in neurons that subsequently degenerate. Cotman C  Su J 
    • Neuregulin also mediates cyclin-dependent kinase 5 and glycogen synthase kinase 3β (GSK3b) activity that increase tau phosphorylation and APP processing. Bartzokis G 
    • Mechanisms exist by which Aβ and tau can be regulated by single upstream drivers in late-onset AD (LOAD). Small S  Duff K 

    Alternative statements
    

    • Aβ toxicity is tau dependent. Hardy J  Selkoe D 

    Genes/Proteins
    

    • Protein: Microtubule-associated protein tau [Homo sapiens]
• Created On: Tue, Mar 24 21:31:24 EDT 2009
• Last Modified On: Tue Mar 24 21:31:24 EDT 2009