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• p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.
• Citation:
  Cruz J, Kim D, Moy L, Dobbin M, Sun X, Bronson R, Tsai L
  

  p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Oct 11;26(41):10536-41
  [PubMed] [Alzforum]
• Supporting:
  • In the forebrains of p25 transgenic mice, SIRT1 protein levels increased as early as 2 weeks after p25 induction and persisted throughout the progression of the pathology to 12 weeks.

    SHOW Details   Supporting(3)     Genes/Proteins: (2)

    Description: Mice inducibly overexpressing p25, a toxic coactivator of cyclin-dependent kinase 5 (CDK5), display massive degeneration of forebrain with features of AD. p25 has been implicated in various neurotoxic conditions such as AD, ALS and stroke.
    Experimental Approach: Mechanism - molecular and cell,   Pathophysiology,   Animal models,   Genetics,  
    Pathogenic Narrative Tags: Perturbation
    Supporting Evidence
    

    • Cruz J, Kim D, Moy L, Dobbin M, Sun X, Bronson R, Tsai L
      p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.
      The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Oct 11;26(41):10536-41
    • Kim D, Nguyen M, Dobbin M, Fischer A, Sananbenesi F, Rodgers J, Delalle I, Baur J, Sui G, Armour S, Puigserver P, Sinclair D, Tsai L
      SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
      The EMBO journal. 2007 Jul 11;26(13):3169-79
    • Cruz J, Tseng H, Goldman J, Shih H, Tsai L
      Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles.
      Neuron. 2003 Oct 30;40(3):471-83

    Genes/Proteins
    

    • Protein: NAD-dependent deacetylase sirtuin-1 [Mus musculus]
    • Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) [Homo sapiens]
• Created On: Mon, Sep 22 11:08:00 EDT 2008
• Last Modified On: Mon Sep 22 11:08:00 EDT 2008