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• Neuropathology of older persons without cognitive impairment from two community-based studies.
• Citation:
  Bennett D, Schneider J, Arvanitakis Z, Kelly J, Aggarwal N, Shah R, Wilson R
  

  Neuropathology of older persons without cognitive impairment from two community-based studies.

  Neurology. 2006 Jun 27;66(12):1837-44
  [PubMed] [Alzforum]
• Supporting:
  • Postmortem observations show that the neuropathology of AD, including cerebral deposits of amyloid-β (Aβ) and neurofibrillary changes associated with hyperphosphorylated tau, is present in an age-dependent manner in a substantial proportion of cognitively normal older adults.

    SHOW Details   Supporting(3)     Genes/Proteins: (1)

    Experimental Approach: Mechanism - biochemistry and structural biology,   Neuropsychology/Behavior,   Biomarkers,   Pathophysiology,  
    Pathogenic Narrative Tags: Pathologic change
    Supporting Evidence
    

    • Price J, McKeel D, Buckles V, Roe C, Xiong C, Grundman M, Hansen L, Petersen R, Parisi J, Dickson D, Smith C, Davis D, Schmitt F, Markesbery W, Kaye J, Kurlan R, Hulette C, Kurland B, Higdon R, Kukull W, Morris J
      Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease.
      Neurobiology of aging. 2009 Jul;30(7):1026-36
    • Knopman D, Parisi J, Salviati A, Floriach-Robert M, Boeve B, Ivnik R, Smith G, Dickson D, Johnson K, Petersen L, McDonald W, Braak H, Petersen R
      Neuropathology of cognitively normal elderly.
      Journal of neuropathology and experimental neurology. 2003 Nov;62(11):1087-95
    • Bennett D, Schneider J, Arvanitakis Z, Kelly J, Aggarwal N, Shah R, Wilson R
      Neuropathology of older persons without cognitive impairment from two community-based studies.
      Neurology. 2006 Jun 27;66(12):1837-44

    Genes/Proteins
    

    • Protein: Beta-amyloid protein 42 [Homo sapiens]
• Created On: Mon, Mar 22 21:35:01 EDT 2010
• Last Modified On: Mon Mar 22 21:35:01 EDT 2010