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• Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5.
• Citation:
  Wang Q, Walsh D, Rowan M, Selkoe D, Anwyl R
  

  Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5.

  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Mar 31;24(13):3370-8
  [PubMed] [Alzforum]
• Supporting:
  • Additional studies have confirmed that conditioned media from V717F APP751 transfected cells does not alter baseline transmission, using mouse hippocampal slice cultures in vitro.

    SHOW Details   Supporting(3)   Consistent(1) 

    Experimental Approach: Mechanism - biochemistry and structural biology,   Pathophysiology
    Pathogenic Narrative Tags: Pathogenic event
    Supporting Evidence
    

    • Townsend M, Shankar G, Mehta T, Walsh D, Selkoe D
      Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.
      The Journal of physiology. 2006 Apr 15;572(Pt 2):477-92
    • Wang Q, Walsh D, Rowan M, Selkoe D, Anwyl R
      Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5.
      The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Mar 31;24(13):3370-8
    • Walsh D, Townsend M, Podlisny M, Shankar G, Fadeeva J, El Agnaf O, Hartley D, Selkoe D
      Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.
      The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Mar 9;25(10):2455-62

    Consistent statements
    

    • Conditioned media from V717F APP751 transfected cells did not affect baseline transmission in the absence of high-frequency stimulation. Walsh D  Klyubin I  Fadeeva J  Cullen W  Anwyl R  Wolfe M  Rowan M  Selkoe D 
• Created On: Thu, Apr 24 17:12:58 EDT 2008
• Last Modified On: Thu Apr 24 17:12:58 EDT 2008