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• Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade.
• Citation:
  Taru H, Iijima K, Hase M, Kirino Y, Yagi Y, Suzuki T
  

  Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade.

  The Journal of biological chemistry. 2002 May 31;277(22):20070-8
  [PubMed] [Alzforum]
• Supporting:
  • CDC2 kinase is the first protein kinase that has been shown to phosphorylate APP in cells. In addition, several proline-directed protein kinases such as CDK5 and JNK are known to phosphorylate APP at Thr668.

    SHOW Details   Supporting(1)   Consistent(1) 

    Experimental Approach: Mechanism - biochemistry and structural biology,  
    Pathogenic Narrative Tags: Initial condition
    Supporting Evidence
    

    • Taru H, Iijima K, Hase M, Kirino Y, Yagi Y, Suzuki T
      Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade.
      The Journal of biological chemistry. 2002 May 31;277(22):20070-8

    Consistent statements
    

    • Phosphorylation of the mature (mAPP) and the immature (imAPP) forms of APP is elevated at the G2/M phase, demonstrating that APP is a physiological substrate for cdc2 kinase in vivo, when cdc2 kinase is most active. Suzuki T  Oishi M  Marshak D  Czernik A  Nairn A  Greengard P 
  • APP is a type I membrane protein, thus, the intracellular transport and metabolism are regulated by the cytoplasmic tail composing of 47 amino acids. There have been many reports of proteins which bind to the APP cytoplasmic domain. It is well known that some of these regulate the metabolism and trafficking of APP.

    SHOW Details   Supporting(11)   Consistent(1) 

    Experimental Approach: Mechanism - biochemistry and structural biology,  
    Pathogenic Narrative Tags: Initial condition
    Supporting Evidence
    

    • Matsuda S, Yasukawa T, Homma Y, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S, Kita Y, Kawasumi M, Kouyama K, Yamamoto T, Kyriakis J, Nishimoto I
      c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK.
      The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Sep 1;21(17):6597-607
    • Sano Y, Syuzo-Takabatake A, Nakaya T, Saito Y, Tomita S, Itohara S, Suzuki T
      Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain.
      The Journal of biological chemistry. 2006 Dec 8;281(49):37853-60
    • Minopoli G, de Candia P, Bonetti A, Faraonio R, Zambrano N, Russo T
      The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation.
      The Journal of biological chemistry. 2001 Mar 2;276(9):6545-50
    • Fiore F, Zambrano N, Minopoli G, Donini V, Duilio A, Russo T
      The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein.
      The Journal of biological chemistry. 1995 Dec 29;270(52):30853-6
    • Taru H, Iijima K, Hase M, Kirino Y, Yagi Y, Suzuki T
      Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade.
      The Journal of biological chemistry. 2002 May 31;277(22):20070-8
    • Taru H, Kirino Y, Suzuki T
      Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism.
      The Journal of biological chemistry. 2002 Jul 26;277(30):27567-74
    • Lee J, Lau K, Perkinton M, Standen C, Shemilt S, Mercken L, Cooper J, McLoughlin D, Miller C
      The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.
      The Journal of biological chemistry. 2003 Nov 21;278(47):47025-9
    • Lee J, Lau K, Perkinton M, Standen C, Rogelj B, Falinska A, McLoughlin D, Miller C
      The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.
      The Journal of biological chemistry. 2004 Nov 19;279(47):49099-104
    • Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T
      Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.
      The Journal of biological chemistry. 1999 Jan 22;274(4):2243-54
    • McLoughlin D, Irving N, Brownlees J, Brion J, Leroy K, Miller C
      Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease.
      The European journal of neuroscience. 1999 Jun;11(6):1988-94
    • Borg J, Yang Y, De Taddéo-Borg M, Margolis B, Turner R
      The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.
      The Journal of biological chemistry. 1998 Jun 12;273(24):14761-6

    Consistent statements
    

    • APP is a phosphoprotein and contains several putative phosphorylation sites in its cytoplasmic domain. Suzuki T  Oishi M  Marshak D  Czernik A  Nairn A  Greengard P 
• Created On: Wed, Jun 04 12:06:42 EDT 2008
• Last Modified On: Wed Jun 04 12:06:42 EDT 2008