AlzSWAN Knowledge Base

Powered by SWAN (Semantic Web Applications in Neuromedicine)

• DNA replication precedes neuronal cell death in Alzheimer's disease.
• Citation:
  Yang Y, Geldmacher D, Herrup K
  

  DNA replication precedes neuronal cell death in Alzheimer's disease.

  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Apr 15;21(8):2661-8
  [PubMed] [Alzforum]
• Supporting:
  • In human AD, neuronal cell cycle events (CCEs) are observed in neurons subject to neurodegeneration in patients early in the disease process as indicated by their presence in patients with mild cognitive impairment suggesting that neuronal CCEs represent an early marker of neuronal distress and disease pathogenesis.

    SHOW Details   Supporting(3)   Consistent(3) 

    Experimental Approach: Mechanism - biochemistry and structural biology,   Neuropsychology/Behavior,   Mechanism - molecular and cell
    Pathogenic Narrative Tags: Pathogenic event
    Supporting Evidence
    

    • Yang Y, Geldmacher D, Herrup K
      DNA replication precedes neuronal cell death in Alzheimer's disease.
      The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Apr 15;21(8):2661-8
    • Yang Y, Mufson E, Herrup K
      Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.
      The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Apr 1;23(7):2557-63
    • Busser J, Geldmacher D, Herrup K
      Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.
      The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Apr 15;18(8):2801-7

    Consistent statements
    

    • Cell cycle-dependent phosphorylation of APP at Thr668 is associated with altered APP metabolism. Suzuki T  Oishi M  Marshak D  Czernik A  Nairn A  Greengard P 
    • Ectopic stimulation of Fyn activity, which can be mitogenic, potentially could lead to nerve cell death via mitotic catastrophe to trigger cell death, an idea supported by findings that the AD brain has ectopically expressed cell cycle proteins. Lambert M  Barlow A  Chromy B  Edwards C  Freed R  Liosatos M  Morgan T  Rozovsky I  Trommer B  Viola K  Wals P  Zhang C  Finch C  Krafft G  Klein W 
    • Cytoplasmic or nuclear protein markers associated with senescent cells are often cell-cycle proteins, tumor suppressors, or cell-cycle regulators. Golde T  Miller V 
  • Expression of cell cycle proteins and DNA synthesis is observed in neurons susceptible to death in AD.

    SHOW Details   Supporting(5)   Consistent(3) 

    Experimental Approach: Mechanism - molecular and cell,   Pathophysiology,   Mechanism - biochemistry and structural biology,  
    Pathogenic Narrative Tags: Perturbation
    Supporting Evidence
    

    • Yang Y, Mufson E, Herrup K
      Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.
      The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Apr 1;23(7):2557-63
    • Vincent I, Rosado M, Davies P
      Mitotic mechanisms in Alzheimer's disease?
      The Journal of cell biology. 1996 Feb;132(3):413-25
    • Yang Y, Geldmacher D, Herrup K
      DNA replication precedes neuronal cell death in Alzheimer's disease.
      The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Apr 15;21(8):2661-8
    • Petersen R
      Mild cognitive impairment: transition between aging and Alzheimer's disease.
      Neurología (Barcelona, Spain). 2000 Mar;15(3):93-101
    • Arendt T, Rödel L, Gärtner U, Holzer M
      Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease.
      Neuroreport. 1996 Nov 25;7(18):3047-9

    Consistent statements
    

    • In AD and other neurodegenerative diseases there is often marked upregulation of cyclins, p53 and related proteins, and cyclin-dependent kinase inhibitors that have also been implicated in the senescent phenotype, often upregulated in tangle-bearing neurons. Golde T  Miller V 
    • Inappropriate reactivation of the cell cycle is an early and important event in the development of Alzheimer disease. Vincent I  Rosado M  Davies P 
    • Several reports describe aberrant regulation of cell cycle factors in AD brain. Suzuki T 
• Created On: Tue, May 05 14:25:45 EDT 2009
• Last Modified On: Tue May 05 14:25:45 EDT 2009