Alternative to: (2)
Description: The authors hypothesize the existence of soluble Aβ assemblies that disrupt memory. This Aβ satisfied two criteria: that its appearance should coincide with early memory loss and then remain stable in middle-aged mice. Experimental Approach:Mechanism - biochemistry and structural biology,
Pathogenic Narrative Tags:Pathologic change Supporting Evidence
Rather than amyloid being responsible for causing disease, we suspect that Alzheimer Disease is responsible for causing amyloid. In fact, amyloid may even be a protective response. As such, removing amyloid would be predicted to either have no effect or a detrimental effect on AD progression.