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• Neurotrophins are required for nerve growth during development.
• Citation:
  Tucker K, Meyer M, Barde Y
  

  Neurotrophins are required for nerve growth during development.

  Nature neuroscience. 2001 Jan;4(1):29-37
  [PubMed] [Alzforum]
• Supporting:
  • The normal transport patterns of NF-L and snap25 along optic axons of tau-null mice indicate that tau is not essential for axonal transport in vivo and may be compensated by other proteins as suggested by the absence of detectable phenotype in mice lacking tau.

    SHOW Details   Supporting(3)   Inconsistent(1)     Genes/Proteins: (2)

    Experimental Approach: Mechanism - molecular and cell,   Genetics,   Biomarkers,   Animal models
    Pathogenic Narrative Tags: Perturbation
    Supporting Evidence
    

    • Harada A, Oguchi K, Okabe S, Kuno J, Terada S, Ohshima T, Sato-Yoshitake R, Takei Y, Noda T, Hirokawa N
      Altered microtubule organization in small-calibre axons of mice lacking tau protein.
      Nature. 1994 Jun 9;369(6480):488-91
    • Tucker K, Meyer M, Barde Y
      Neurotrophins are required for nerve growth during development.
      Nature neuroscience. 2001 Jan;4(1):29-37
    • Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, Hirokawa N, Nukina N, Ihara Y
      Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau.
      The Journal of biological chemistry. 2004 Jun 25;279(26):27272-7

    Inconsistent statements
    

    • Tau knockout mice develop cognitive and motor abnormalities with age, signifying that reducing tau levels may have negative consequences. Lee V  Trojanowski J 

    Genes/Proteins
    

    • Protein: Neurofilament light polypeptide [Mus musculus]
    • Protein: Synaptosomal-associated protein 25 [Mus musculus]
  • Previous studies showed that brain tau is absent in tau knock-out mice and is overexpressed in 8c mice.

    SHOW Details   Supporting(2) 

    Experimental Approach: Animal models,   Genetics,  
    Pathogenic Narrative Tags: Perturbation
    Supporting Evidence
    

    • Duff K, Knight H, Refolo L, Sanders S, Yu X, Picciano M, Malester B, Hutton M, Adamson J, Goedert M, Burki K, Davies P
      Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes.
      Neurobiology of disease. 2000 Apr;7(2):87-98
    • Tucker K, Meyer M, Barde Y
      Neurotrophins are required for nerve growth during development.
      Nature neuroscience. 2001 Jan;4(1):29-37
• Created On: Wed, Apr 23 05:46:29 EDT 2008
• Last Modified On: Wed Apr 23 05:46:29 EDT 2008