{"items":[{"type":"AlzheimerDiseaseHypothesisTaxonomy","label":"AD Hypothesis Taxonomy"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","label":"Structural Changes of Proteins"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Structural Changes of Proteins","label":"Amyloid"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Amyloid","label":"Protein Synthesis"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Amyloid","label":"Protein Processing"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Amyloid","label":"Protein Aggregation and Deposition"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Amyloid","label":"Protein Degradation"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Structural Changes of Proteins","label":"Cytoskeletal Proteins"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Structural Changes of Proteins","label":"Synapses"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","label":"Functional Changes of Proteins"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Functional Changes of Proteins","label":"ApoE"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Functional Changes of Proteins","label":"Hormones"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Functional Changes of Proteins","label":"Trophic Factors"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Functional Changes of Proteins","label":"Apoptosis"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Functional Changes of Proteins","label":"Protease Activation"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Functional Changes of Proteins","label":"Inflammation"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","label":"Energetics"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Energetics","label":"Circulation"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Energetics","label":"Metabolism"},{"type":"AlzheimerDiseaseHypothesisTaxonomy","subtopicOf":"Energetics","label":"Oxidation"},{"lsid":"urn:lsid:swan.org:researchstatement:961a7b56-cc9d-4924-a309-9bb6440965af","title":"Impaired DNA repair in neurons sensitizes them to oxidative damage induced by Aβ.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2002-03-01","id":"urn:lsid:swan.org:researchstatement:961a7b56-cc9d-4924-a309-9bb6440965af","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:961a7b56-cc9d-4924-a309-9bb6440965af&referrerLinkLabel=hypothesislist","label":"Kruman I et al.; Impaired DNA repair in neurons sensitize...","HotTopics":["The molecular mechanisms of neuronal cell death are involved in the dysfunction and death of neurons in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Kumaravel T S","Lohani Althaf","Pedersen Ward A","Cutler Roy G","Kruman Yuri","Haughey Norman","Lee Jaewon","Evans Michele","Mattson Mark P"],"firstAuthor":"Kruman Inna I","taxonomy":["Metabolism"],"referenceYear":"2002"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:90201dde-fc18-4012-ae9f-aeb3aa65dd4d\" title=\"Gene: VPS26A vacuolar protein sorting 26 homolog A (S. pombe) [Homo sapiens]\">VPS26A<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:0d83599b-5e6f-4337-bebb-3fc623352ada\" title=\"Gene: SORL1 sortilin-related receptor, L(DLR class) A repeats-containing [Homo sapiens]\">SORL1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:81b26546-9318-4891-9410-6d48964bb2bf\" title=\"Gene: VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) [Homo sapiens]\">VPS35<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:beb73abe-e850-4182-998e-a7a847447b41\" title=\"Protein: Apolipoprotein E [Homo sapiens]\">Apolipoprotein E<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:c9b06bab-c14c-4b73-b207-dda49f3a5939\" title=\"Gene: GSK3B glycogen synthase kinase 3 beta [Homo sapiens]\">GSK3B<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:607f4fa6-5204-44ac-81c5-b3957f9f2855\" title=\"Gene: MAPT microtubule-associated protein tau [Homo sapiens]\">MAPT<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b4f3109c-0624-4096-be2d-b75fd6598c31\" title=\"Protein: Glycogen synthase kinase-3 beta [Homo sapiens]\">Glycogen synthase kinase-3 beta<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d8a05505-c2f0-44ff-b51e-11f8b8fc1331\" title=\"Protein: Low-density lipoprotein receptor-related protein 6 [Homo sapiens]\">Low-density lipoprotein receptor-related protein 6<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:cfdaa5e5-f0e7-43f1-9347-558c2044dee8\" title=\"Gene: PSEN2 presenilin 2 (Alzheimer disease 4) [Homo sapiens]\">PSEN2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:37e48ae6-7eb8-49fc-b38d-b61639895993\" title=\"Gene: CTNNA3 catenin (cadherin-associated protein), alpha 3 [Homo sapiens]\">CTNNA3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:32d3fca2-ca67-4c01-a873-f1887ae60d08\" title=\"Gene: LRP6 low density lipoprotein receptor-related protein 6 [Homo sapiens]\">LRP6<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=4932\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Saccharomyces cerevisiae<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:1b4d01f2-0cfe-4156-a1bb-159fa1481180\" title=\"Protein: Vacuolar protein sorting/targeting protein PEP1 precursor [Saccharomyces cerevisiae]\">Vacuolar protein sorting/targeting protein PEP1 precursor<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:5a93fa99-953d-450f-93c7-1909c1b2a96b\" title=\"Gene: Vps26a vacuolar protein sorting 26 homolog A (yeast) [Mus musculus]\">Vps26a<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:2d78eb55-a7f2-4949-b16f-257a0bb36560\" title=\"Protein: Sortilin [Mus musculus]\">Sortilin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:16aaae39-8e7d-4981-a109-0c6246672b69\" title=\"Protein: Vacuolar protein sorting-associated protein 26A [Mus musculus]\">Vacuolar protein sorting-associated protein 26A<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:54332c21-c629-4cd1-8e55-0dd7f7350680\" title=\"Protein: Vacuolar protein sorting-associated protein 35 [Mus musculus]\">Vacuolar protein sorting-associated protein 35<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6ad3fdfc-2792-47ed-9fef-cc98db7fef9b\" title=\"Protein: Sortilin-related receptor [Mus musculus]\">Sortilin-related receptor<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:faa8008f-3518-4398-be1c-295312fddf5b\" title=\"Gene: Vps35 vacuolar protein sorting 35 [Mus musculus]\">Vps35<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:178c8816-c8d6-4313-95f9-608e395b728a\" title=\"Gene: Sorl1 sortilin-related receptor, LDLR class A repeats-containing [Mus musculus]\">Sorl1<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e0c8e389-8ea7-4988-9509-7b93ae248068&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e0c8e389-8ea7-4988-9509-7b93ae248068&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"A \u2018\u2018dual pathway\u2019\u2019 model of AD causality, whereby Aβ and tau can be linked by\nseparate mechanisms driven by a common upstream driver.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e0c8e389-8ea7-4988-9509-7b93ae248068&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":3,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e0c8e389-8ea7-4988-9509-7b93ae248068&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:e0c8e389-8ea7-4988-9509-7b93ae248068","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e0c8e389-8ea7-4988-9509-7b93ae248068&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Insoluble fibrillar Aβ leads to AD","Tau dysfunction mediates neurodegeneration"],"supportedby":15,"containedwithoutevidence":5,"taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"2008","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e0c8e389-8ea7-4988-9509-7b93ae248068&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:e0c8e389-8ea7-4988-9509-7b93ae248068","containedwithevidence":30,"type":"Hypothesis","contained":35,"status":"Extended Annotation","referenceDate":"2008-11-26","containedevidencecount":122,"alternativeto":7,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e0c8e389-8ea7-4988-9509-7b93ae248068&referrerLinkLabel=hypothesislist","label":"Small S et al.; A \u2018\u2018dual pathway\u2019\u2019 model of AD causality...","otherAuthors":["Duff Karen"],"firstAuthor":"Small Scott A"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ebc67c10-384c-4ca1-984d-71709f5d3d74&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ebc67c10-384c-4ca1-984d-71709f5d3d74&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Cell cycle-dependent regulation of APP metabolism and phosphorylation play a key role in AD pathogenesis.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ebc67c10-384c-4ca1-984d-71709f5d3d74&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":2,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ebc67c10-384c-4ca1-984d-71709f5d3d74&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:ebc67c10-384c-4ca1-984d-71709f5d3d74","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ebc67c10-384c-4ca1-984d-71709f5d3d74&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["The molecular mechanisms of neuronal cell death are involved in the dysfunction and death of neurons in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":16,"containedwithoutevidence":16,"referenceYear":"1994","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ebc67c10-384c-4ca1-984d-71709f5d3d74&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:ebc67c10-384c-4ca1-984d-71709f5d3d74","containedwithevidence":46,"type":"Hypothesis","contained":62,"status":"Extended Annotation","referenceDate":"1994-03-01","containedevidencecount":70,"alternativeto":4,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ebc67c10-384c-4ca1-984d-71709f5d3d74&referrerLinkLabel=hypothesislist","label":"Suzuki T et al.; Cell cycle-dependent regulation of APP m...","otherAuthors":["Oishi M","Marshak D R","Czernik A J","Nairn A C","Greengard P"],"firstAuthor":"Suzuki T"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:607f4fa6-5204-44ac-81c5-b3957f9f2855\" title=\"Gene: MAPT microtubule-associated protein tau [Homo sapiens]\">MAPT<\/a>; ","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e9edfa07-9a07-480a-bb92-26ad340d6212&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Extracellular tau aggregates can transmit a misfolded state from the outside to the inside of a cell, similar to prions.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e9edfa07-9a07-480a-bb92-26ad340d6212&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:e9edfa07-9a07-480a-bb92-26ad340d6212","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e9edfa07-9a07-480a-bb92-26ad340d6212&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Tau dysfunction mediates neurodegeneration"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":1,"containedwithoutevidence":1,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e9edfa07-9a07-480a-bb92-26ad340d6212&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:e9edfa07-9a07-480a-bb92-26ad340d6212","containedwithevidence":8,"type":"Hypothesis","contained":9,"status":"Extended Annotation","referenceDate":"2009-05-08","containedevidencecount":15,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e9edfa07-9a07-480a-bb92-26ad340d6212&referrerLinkLabel=hypothesislist","label":"Frost B et al.; Extracellular tau aggregates can transmi...","otherAuthors":["Jacks Rachel L","Diamond Marc I"],"firstAuthor":"Frost Bess"},{"lsid":"urn:lsid:swan.org:researchstatement:fa86cd31-0f06-459e-86c0-c744cf4278ba","title":"Tau plays a role in the malfunctioning of axonal transport.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2003-12","id":"urn:lsid:swan.org:researchstatement:fa86cd31-0f06-459e-86c0-c744cf4278ba","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:fa86cd31-0f06-459e-86c0-c744cf4278ba&referrerLinkLabel=hypothesislist","label":"Mandelkow E et al.; Tau plays a role in the malfunctioning o...","HotTopics":["Failure of axonal transport might be the underlying basis for neurodegeneration in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Stamer K","Vogel R","Thies E","Mandelkow E"],"firstAuthor":"Mandelkow E-M","taxonomy":["Synapses"],"referenceYear":"2003"},{"lsid":"urn:lsid:swan.org:researchstatement:13ae900a-add5-477f-ac4e-699a63b85487","title":"Amyloid beta oligomers induce impairment of neuronal insulin receptors.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2008-01","id":"urn:lsid:swan.org:researchstatement:13ae900a-add5-477f-ac4e-699a63b85487","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:13ae900a-add5-477f-ac4e-699a63b85487&referrerLinkLabel=hypothesislist","label":"Zhao W et al.; Amyloid beta oligomers induce impairment...","HotTopics":["Soluble oligomeric aggregates of Aβ are toxic to neurons and cause AD pathology"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["De Felice Fernanda G.","Fernandez Sara J","Chen Hui","Lambert Mary P","Quon Michael J.","Krafft Grant A","Klein William L"],"firstAuthor":"Zhao Wei-Qin","taxonomy":["Structural Changes of Proteins"],"referenceYear":"2008"},{"lsid":"urn:lsid:swan.org:researchstatement:b847aa2b-a522-41a5-adc9-22ce336108d5","title":"Infection with the organism Chlamydia pneumoniae is a risk factor for late-onset Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1998-06","id":"urn:lsid:swan.org:researchstatement:b847aa2b-a522-41a5-adc9-22ce336108d5","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b847aa2b-a522-41a5-adc9-22ce336108d5&referrerLinkLabel=hypothesislist","label":"Balin B et al.; Infection with the organism Chlamydia pn...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Gérard H C","Arking E J","Appelt D M","Branigan P J","Abrams J T","Whittum-Hudson J A","Hudson A P"],"firstAuthor":"Balin B J","taxonomy":["Oxidation"],"referenceYear":"1998"},{"lsid":"urn:lsid:swan.org:researchstatement:471b60a0-fc9a-41b6-9e95-ad8009ae2bdf","title":"Cerebral Aβ amyloidosis can be induced by infectious protein.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2006-07","id":"urn:lsid:swan.org:researchstatement:471b60a0-fc9a-41b6-9e95-ad8009ae2bdf","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:471b60a0-fc9a-41b6-9e95-ad8009ae2bdf&referrerLinkLabel=hypothesislist","label":"Walker L et al.; Cerebral Aβ amyloidosis can be induced b...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Levine Harry","Jucker Mathias"],"firstAuthor":"Walker Lary","taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"2006"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:87fd6477-4c25-4086-8a6c-2b376ec86eed\" title=\"Protein: Beta-secretase 1 [Mus musculus]\">Beta-secretase 1<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d8221a00-583b-4f53-9743-d9d85e5bd42d&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Brainstem neurons are initiators of neuritic plaques.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d8221a00-583b-4f53-9743-d9d85e5bd42d&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":2,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d8221a00-583b-4f53-9743-d9d85e5bd42d&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:d8221a00-583b-4f53-9743-d9d85e5bd42d","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d8221a00-583b-4f53-9743-d9d85e5bd42d&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Insoluble fibrillar Aβ leads to AD"],"supportedby":13,"containedwithoutevidence":0,"taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"2008","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d8221a00-583b-4f53-9743-d9d85e5bd42d&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:d8221a00-583b-4f53-9743-d9d85e5bd42d","containedwithevidence":27,"type":"Hypothesis","contained":27,"status":"Extended Annotation","referenceDate":"2008","containedevidencecount":96,"alternativeto":3,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d8221a00-583b-4f53-9743-d9d85e5bd42d&referrerLinkLabel=hypothesislist","label":"Muresan Z et al.; Brainstem neurons are initiators of neur...","otherAuthors":["Muresan Virgil"],"firstAuthor":"Muresan Zoia"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:8eb63653-6e22-4321-aeac-c153bb266b20\" title=\"Gene: SNCA synuclein, alpha (non A4 component of amyloid precursor) [Homo sapiens]\">SNCA<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d1b70427-57d3-4d6d-951d-9fc185717d9c\" title=\"Protein: Alpha-synuclein [Homo sapiens]\">Alpha-synuclein<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3d9e70ab-2f7d-49c6-94c1-2370b6d237c6\" title=\"Protein: Neurofilament light polypeptide [Mus musculus]\">Neurofilament light polypeptide<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:437dbc9a-4fc5-48a5-a556-7b2f3fc9086f\" title=\"Protein: Synaptosomal-associated protein 25 [Mus musculus]\">Synaptosomal-associated protein 25<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:339e36dd-56aa-43cb-9c66-a66083f6d318\" title=\"Protein: Neurofilament medium polypeptide [Mus musculus]\">Neurofilament medium polypeptide<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e02dc3a7-d334-4ba4-9474-5dadce8ca9f6\" title=\"Protein: Microtubule-associated protein tau [Mus musculus]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:7a4c6234-56d4-4b82-8e80-4022d4dea1a9\" title=\"Protein: Neurofilament heavy polypeptide [Mus musculus]\">Neurofilament heavy polypeptide<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:8ca349c2-ca8e-415a-90f3-a62727d37f17\" title=\"Protein: Alpha-internexin [Mus musculus]\">Alpha-internexin<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:319b4ab0-0503-4f23-aa16-80f3cbc8c877&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:319b4ab0-0503-4f23-aa16-80f3cbc8c877&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Axonal transport is not impaired by changes in tau gene expression levels.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:319b4ab0-0503-4f23-aa16-80f3cbc8c877&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":10,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:319b4ab0-0503-4f23-aa16-80f3cbc8c877&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:319b4ab0-0503-4f23-aa16-80f3cbc8c877","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:319b4ab0-0503-4f23-aa16-80f3cbc8c877&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Failure of axonal transport might be the underlying basis for neurodegeneration in Alzheimer Disease","Tau dysfunction mediates neurodegeneration"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":8,"containedwithoutevidence":11,"referenceYear":"2008","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:319b4ab0-0503-4f23-aa16-80f3cbc8c877&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:319b4ab0-0503-4f23-aa16-80f3cbc8c877","containedwithevidence":38,"type":"Hypothesis","contained":49,"status":"Extended Annotation","referenceDate":"2008-02-13","containedevidencecount":46,"alternativeto":10,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:319b4ab0-0503-4f23-aa16-80f3cbc8c877&referrerLinkLabel=hypothesislist","label":"Yuan A et al.; Axonal transport is not impaired by chan...","otherAuthors":["Kumar Asok","Peterhoff Corrinne M","Duff Karen","Nixon Ralph A"],"firstAuthor":"Yuan Aidong"},{"refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:96a1eb87-1fbd-4c60-8f93-e516d9f0bc17&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:96a1eb87-1fbd-4c60-8f93-e516d9f0bc17&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Oligomerization of Aβ 40 and 42 occurs via distinct pathways.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:96a1eb87-1fbd-4c60-8f93-e516d9f0bc17&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":2,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:96a1eb87-1fbd-4c60-8f93-e516d9f0bc17&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:96a1eb87-1fbd-4c60-8f93-e516d9f0bc17","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:96a1eb87-1fbd-4c60-8f93-e516d9f0bc17&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Soluble oligomeric aggregates of Aβ are toxic to neurons and cause AD pathology"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":26,"containedwithoutevidence":12,"referenceYear":"2003","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:96a1eb87-1fbd-4c60-8f93-e516d9f0bc17&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:96a1eb87-1fbd-4c60-8f93-e516d9f0bc17","containedwithevidence":30,"type":"Hypothesis","contained":42,"status":"Extended Annotation","referenceDate":"2003-01-07","containedevidencecount":52,"alternativeto":4,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:96a1eb87-1fbd-4c60-8f93-e516d9f0bc17&referrerLinkLabel=hypothesislist","label":"Bitan G et al.; Oligomerization of Aβ 40 and 42 occurs v...","otherAuthors":["Kirkitadze Marina D","Lomakin Aleksey","Vollers Sabrina S","Benedek George B","Teplow David B"],"firstAuthor":"Bitan Gal"},{"lsid":"urn:lsid:swan.org:researchstatement:5c55a298-13de-42a7-b226-10dc2ec12fe4","title":"  \t\n\nAlzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1997-09-05","id":"urn:lsid:swan.org:researchstatement:5c55a298-13de-42a7-b226-10dc2ec12fe4","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:5c55a298-13de-42a7-b226-10dc2ec12fe4&referrerLinkLabel=hypothesislist","label":"Li J et al.;   \t\n\nAlzheimer presenilins in the nuclea...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Xu M","Zhou H","Ma J","Potter H"],"firstAuthor":"Li J","referenceYear":"1997"},{"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:2dc11ccb-6c2a-4821-9d9d-423ada52d9c0&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:2dc11ccb-6c2a-4821-9d9d-423ada52d9c0","type":"Hypothesis","title":"Viruses and dementia, and the role of apolipoprotein (ApoE).","label":"Itzhaki R; Viruses and dementia, and the role of ap...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","status":"Simple Annotation","firstAuthor":"Itzhaki R F","id":"urn:lsid:swan.org:researchstatement:2dc11ccb-6c2a-4821-9d9d-423ada52d9c0"},{"lsid":"urn:lsid:swan.org:researchstatement:1377bf42-dcf2-4ed9-af72-d59a1af84e0f","title":"The catastrophic loss of cerebral neurons in Alzheimer disease is the result of an autoimmune process.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2005","id":"urn:lsid:swan.org:researchstatement:1377bf42-dcf2-4ed9-af72-d59a1af84e0f","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1377bf42-dcf2-4ed9-af72-d59a1af84e0f&referrerLinkLabel=hypothesislist","label":"D'Andrea M; The catastrophic loss of cerebral neuron...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","firstAuthor":"D'Andrea Michael R","taxonomy":["Inflammation"],"referenceYear":"2005"},{"lsid":"urn:lsid:swan.org:researchstatement:49cb5698-ff87-49a6-b00b-83968dd6df28","title":"APP misprocessing causes Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1985-12","id":"urn:lsid:swan.org:researchstatement:49cb5698-ff87-49a6-b00b-83968dd6df28","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:49cb5698-ff87-49a6-b00b-83968dd6df28&referrerLinkLabel=hypothesislist","label":"Wong C et al.; APP misprocessing causes Alzheimer disea...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Quaranta V","Glenner G G"],"firstAuthor":"Wong C W","taxonomy":["Protein Processing"],"referenceYear":"1985"},{"lsid":"urn:lsid:swan.org:researchstatement:0f651beb-1c3c-41b3-9f9a-363e0d24d55a","title":"Frameshift mutation of APP, Ubiquitin is likely an important factor in nonfamilial early- and late-onset forms of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1998-01-09","id":"urn:lsid:swan.org:researchstatement:0f651beb-1c3c-41b3-9f9a-363e0d24d55a","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0f651beb-1c3c-41b3-9f9a-363e0d24d55a&referrerLinkLabel=hypothesislist","label":"van Leeuwen F et al.; Frameshift mutation of APP, Ubiquitin is...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["de Kleijn D P","van den Hurk H H","Neubauer A","Sonnemans M A","Sluijs J A","Köycü S","Ramdjielal R D","Salehi A","Martens G J","Grosveld F G","Peter J","Burbach H","Hol E M"],"firstAuthor":"van Leeuwen F W","taxonomy":["Protein Degradation"],"referenceYear":"1998"},{"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b5eb8750-723e-42c6-a77d-964648902a3c&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:b5eb8750-723e-42c6-a77d-964648902a3c","type":"Hypothesis","title":"Disruption of glial cellular function.","label":"Brenner S; Disruption of glial cellular function.","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","status":"Simple Annotation","firstAuthor":"Brenner Steven","id":"urn:lsid:swan.org:researchstatement:b5eb8750-723e-42c6-a77d-964648902a3c"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d2e897f5-85c7-45c1-8068-3d026d0826da\" title=\"Protein: Neuronal acetylcholine receptor subunit beta-4 [Homo sapiens]\">Neuronal acetylcholine receptor subunit beta-4<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:ae7104b2-1815-4e3b-b997-dda3a1c41bc5\" title=\"Gene: CHRNB4 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]\">CHRNB4<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:dbadfcb7-8656-4e76-b76e-9bbe45aea259\" title=\"Gene: CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) [Homo sapiens]\">CHRNB2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:542d068d-181b-4132-84e9-2cae22cb70c2\" title=\"Protein: Neuronal acetylcholine receptor subunit beta-2 [Homo sapiens]\">Neuronal acetylcholine receptor subunit beta-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:cfdaa5e5-f0e7-43f1-9347-558c2044dee8\" title=\"Gene: PSEN2 presenilin 2 (Alzheimer disease 4) [Homo sapiens]\">PSEN2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:31e0662f-9a58-460c-a26d-3b7edeb8989c\" title=\"Gene: ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Homo sapiens]\">ACE<\/a>; ","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:28398ee9-52a7-420d-a429-97f3c865c38a&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"The α4 (CHRNΑ4) and β2 (CHRNΒ2) neuronal nicotinic acetylcholine receptor subunit genes may be involved in impaired neuronal survival and the cholinergic system deficits that are evident in AD.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:28398ee9-52a7-420d-a429-97f3c865c38a&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:28398ee9-52a7-420d-a429-97f3c865c38a&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:28398ee9-52a7-420d-a429-97f3c865c38a","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:28398ee9-52a7-420d-a429-97f3c865c38a&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Genetic variants modulate risk of AD","Signaling mechanisms play a critical role in Alzheimer Disease"],"supportedby":1,"containedwithoutevidence":1,"taxonomy":["Structural Changes of Proteins"],"referenceYear":"2004","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:28398ee9-52a7-420d-a429-97f3c865c38a&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:28398ee9-52a7-420d-a429-97f3c865c38a","containedwithevidence":12,"type":"Hypothesis","contained":13,"status":"Extended Annotation","referenceDate":"2004-03-25","containedevidencecount":21,"alternativeto":4,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:28398ee9-52a7-420d-a429-97f3c865c38a&referrerLinkLabel=hypothesislist","label":"Cook L et al.; The α4 (CHRNΑ4) and β2 (CHRNΒ2) neuronal...","otherAuthors":["Ho Luk W","Taylor Alison E","Brayne Carol","Evans John Grimley","Xuereb John","Cairns Nigel J","Pritchard Antonia","Lemmon Helen","Mann David","St Clair David","Turic Dragana","Hollingworth Paul","Moore Pamela J","Jehu Luke","Archer Nicola","Walter Sarah","Foy Catherine","Edmondson Amanda","Powell John","Lovestone Simon","Owen Michael J","Williams Julie","Lendon Corinne","Rubinsztein David C"],"firstAuthor":"Cook Lynnette J"},{"lsid":"urn:lsid:swan.org:researchstatement:7d312dab-3838-41b3-ba22-3bae398b838a","title":"BACE 1 regulates sodium channels and neuronal activity.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2007-07","id":"urn:lsid:swan.org:researchstatement:7d312dab-3838-41b3-ba22-3bae398b838a","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7d312dab-3838-41b3-ba22-3bae398b838a&referrerLinkLabel=hypothesislist","label":"Kim D et al.; BACE 1 regulates sodium channels and neu...","HotTopics":["Cell membrane properties play a key role in AD Pathophysiology"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Carey Bryce W","Wang Haibin","Ingano Laura A","Binshtok Alexander M","Wertz Mary H","Pettingell Warren H","He Ping","Lee Virginia M-Y","Woolf Clifford J","Kovacs Dora M"],"firstAuthor":"Kim Doo Yeon","taxonomy":["Protein Processing"],"referenceYear":"2007"},{"lsid":"urn:lsid:swan.org:researchstatement:f98b9edf-460b-47bc-acda-86e655d6ad72","title":"Glutamate toxicity may play a role in the pathogenesis of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1988","id":"urn:lsid:swan.org:researchstatement:f98b9edf-460b-47bc-acda-86e655d6ad72","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f98b9edf-460b-47bc-acda-86e655d6ad72&referrerLinkLabel=hypothesislist","label":"Greenamyre J et al.; Glutamate toxicity may play a role in th...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Maragos W F","Albin R L","Penney J B","Young A B"],"firstAuthor":"Greenamyre J T","taxonomy":["Synapses"],"referenceYear":"1988"},{"refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:3de2dc22-afa1-4259-82be-d8d4fd79e532&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:3de2dc22-afa1-4259-82be-d8d4fd79e532&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"The cognitive deficits of early Alzheimer Disease are caused by the disruption of electrical activity and information processing in dendrites of cortical pyramidal neurons.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:3de2dc22-afa1-4259-82be-d8d4fd79e532&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":3,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:3de2dc22-afa1-4259-82be-d8d4fd79e532&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:3de2dc22-afa1-4259-82be-d8d4fd79e532","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:3de2dc22-afa1-4259-82be-d8d4fd79e532&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Cell membrane properties play a key role in AD Pathophysiology"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":7,"containedwithoutevidence":3,"taxonomy":["Structural Changes of Proteins"],"containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:3de2dc22-afa1-4259-82be-d8d4fd79e532&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:3de2dc22-afa1-4259-82be-d8d4fd79e532","containedwithevidence":13,"type":"Hypothesis","contained":16,"status":"Extended Annotation","containedevidencecount":35,"alternativeto":5,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:3de2dc22-afa1-4259-82be-d8d4fd79e532&referrerLinkLabel=hypothesislist","label":"Morse T et al.; The cognitive deficits of early Alzheime...","otherAuthors":["Mutalik Pradeep","Cheung Kei","Miller Perry L","Shepherd Gordon"],"firstAuthor":"Morse Thomas M"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e518d539-6d66-4a1e-a64d-a17a42b5fe13\" title=\"Protein: Protein-glutamine gamma-glutamyltransferase 2 [Homo sapiens]\">Protein-glutamine gamma-glutamyltransferase 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:46a93973-ff08-4203-ae84-d50aeb4141b4\" title=\"Protein: Insulin-degrading enzyme [Homo sapiens]\">Insulin-degrading enzyme<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:5a7afb9f-0c7a-4d9e-9158-614ede751240\" title=\"Protein: Neprilysin [Homo sapiens]\">Neprilysin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:3ec34429-be71-4110-a2db-680b618a3281\" title=\"Gene: TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) [Homo sapiens]\">TGM2<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:474102c8-afc1-49ef-a211-c911d347e96e\" title=\"Protein: Protein-glutamine gamma-glutamyltransferase 2 [Mus musculus]\">Protein-glutamine gamma-glutamyltransferase 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:968eee4c-9c87-4726-99d8-8d06d73f9069\" title=\"Gene: Ide insulin degrading enzyme [Mus musculus]\">Ide<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:12d94644-bd38-4489-b21e-cbac2161dd6f\" title=\"Gene: Mme membrane metallo endopeptidase [Mus musculus]\">Mme<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:79dd6cf7-7c8e-4d10-a536-732d98b53a9e\" title=\"Protein: Neprilysin [Mus musculus]\">Neprilysin<\/a>; ","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:35d62fd9-cbfd-455a-8d31-6409ab5fb62d&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Transglutaminase induces protofibril-like amyloid β-protein assemblies that are protease resistant and inhibit long-term potentiation.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:35d62fd9-cbfd-455a-8d31-6409ab5fb62d&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:35d62fd9-cbfd-455a-8d31-6409ab5fb62d&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:35d62fd9-cbfd-455a-8d31-6409ab5fb62d","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:35d62fd9-cbfd-455a-8d31-6409ab5fb62d&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Soluble oligomeric aggregates of Aβ are toxic to neurons and cause AD pathology"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":6,"containedwithoutevidence":6,"referenceYear":"2008","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:35d62fd9-cbfd-455a-8d31-6409ab5fb62d&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:35d62fd9-cbfd-455a-8d31-6409ab5fb62d","containedwithevidence":34,"type":"Hypothesis","contained":40,"status":"Extended Annotation","referenceDate":"2008-06-13","containedevidencecount":77,"alternativeto":4,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:35d62fd9-cbfd-455a-8d31-6409ab5fb62d&referrerLinkLabel=hypothesislist","label":"Hartley D et al.; Transglutaminase induces protofibril-lik...","otherAuthors":["Zhao Chaohui","Speier Austin C","Woodard Gavitt A","Li Shaomin","Li Zongli","Walz Thomas"],"firstAuthor":"Hartley Dean M"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>; ","containedwithevidence":20,"lsid":"urn:lsid:swan.org:researchstatement:66969a0f-88e6-471f-a793-309d24494b0e","title":"Preclinical AD associated with progression to symptomatic AD is detected by PET Pittsburgh Compound B (PiB).","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:66969a0f-88e6-471f-a793-309d24494b0e&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":20,"status":"Extended Annotation","referenceDate":"2009-12","id":"urn:lsid:swan.org:researchstatement:66969a0f-88e6-471f-a793-309d24494b0e","containedevidencecount":44,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:66969a0f-88e6-471f-a793-309d24494b0e&referrerLinkLabel=hypothesislist","label":"Morris J et al.; Preclinical AD associated with progressi...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Biomarkers are useful for predicting and staging Alzheimer disease"],"otherAuthors":["Roe Catherine M","Grant Elizabeth A","Head Denise","Storandt Martha","Goate Alison M","Fagan Anne M","Holtzman David M","Mintun Mark A"],"containedwithoutevidence":0,"firstAuthor":"Morris John C","referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:66969a0f-88e6-471f-a793-309d24494b0e&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsid":"urn:lsid:swan.org:researchstatement:ed497242-a214-45ff-813d-d42efdbaab2e","title":"Neprilysin is the primary mechanism of Aβ catabolism in hippocampus.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2000-02","id":"urn:lsid:swan.org:researchstatement:ed497242-a214-45ff-813d-d42efdbaab2e","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ed497242-a214-45ff-813d-d42efdbaab2e&referrerLinkLabel=hypothesislist","label":"Iwata N et al.; Neprilysin is the primary mechanism of A...","HotTopics":["Defective mechanisms of Aβ clearance contribute to Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Tsubuki S","Takaki Y","Watanabe K","Sekiguchi M","Hosoki E","Kawashima-Morishima M","Lee H J","Hama E","Sekine-Aizawa Y","Saido T C"],"firstAuthor":"Iwata N","taxonomy":["Protein Degradation"],"referenceYear":"2000"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:7501cc6e-9147-40cf-a277-db928f424295\" title=\"Protein: Insulin [Homo sapiens]\">Insulin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:30e394d9-747b-43a1-9699-a177eb927ce2\" title=\"Protein: Tumor necrosis factor [Homo sapiens]\">Tumor necrosis factor<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f70e6a9a-f79b-405c-8090-f7d6783b10d2\" title=\"Protein: Interleukin-1 alpha [Homo sapiens]\">Interleukin-1 alpha<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:2100b660-5c42-4cae-b136-313b82cfd794\" title=\"Protein: Interleukin-6 [Homo sapiens]\">Interleukin-6<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:3e9b1b05-6495-4394-8706-c90f60a4309d\" title=\"Gene: AKT1 v-akt murine thymoma viral oncogene homolog 1 [Homo sapiens]\">AKT1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:5d14ad26-7a40-454e-9bb7-6e6eabefc455\" title=\"Protein: Insulin receptor substrate 1 [Homo sapiens]\">Insulin receptor substrate 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:46a93973-ff08-4203-ae84-d50aeb4141b4\" title=\"Protein: Insulin-degrading enzyme [Homo sapiens]\">Insulin-degrading enzyme<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b4f3109c-0624-4096-be2d-b75fd6598c31\" title=\"Protein: Glycogen synthase kinase-3 beta [Homo sapiens]\">Glycogen synthase kinase-3 beta<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:7176cb0a-0f55-4225-8ceb-5c6f74072172\" title=\"Protein: Solute carrier family 2, facilitated glucose transporter member 4 [Homo sapiens]\">Solute carrier family 2, facilitated glucose transporter member 4<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Rattus norvegicus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e69b040a-9d0d-424a-9f23-aa96a1edf6a5\" title=\"Protein: Microtubule-associated protein tau [Rattus norvegicus]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:25319247-a3d9-4089-8f74-163ba1e38cd0\" title=\"Protein: Insulin-degrading enzyme [Rattus norvegicus]\">Insulin-degrading enzyme<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:25b1fa71-cf35-4b21-bbeb-f3777591f539\" title=\"Protein: Glutamate [NMDA] receptor subunit zeta-1 [Rattus norvegicus]\">Glutamate [NMDA] receptor subunit zeta-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:c404bcb5-b288-4200-b1d3-d5df789d4738\" title=\"Protein: Solute carrier family 2, facilitated glucose transporter member 3 [Rattus norvegicus]\">Solute carrier family 2, facilitated glucose transporter member 3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:455b14b9-4129-4ad9-b808-96d2f49341f5\" title=\"Protein: Solute carrier family 2, facilitated glucose transporter member 4 [Rattus norvegicus]\">Solute carrier family 2, facilitated glucose transporter member 4<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:31325ca7-b829-4b4d-985d-fd3f71fc0447\" title=\"Protein: Muscarinic acetylcholine receptor M3 [Rattus norvegicus]\">Muscarinic acetylcholine receptor M3<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:751129bb-2878-4a16-8db5-a8823e8cad5c\" title=\"Protein: Insulin-1 [Mus musculus]\">Insulin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:90602c00-8d81-48c6-a5c1-8d929394c903\" title=\"Protein: Insulin-degrading enzyme [Mus musculus]\">Insulin-degrading enzyme<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:64756889-4e77-4735-b12c-2c1c03449590\" title=\"Protein: Glutamate [NMDA] receptor subunit zeta-1 [Mus musculus]\">Glutamate [NMDA] receptor subunit zeta-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:2e35f546-d47e-4395-acbc-465e1ff9a77d\" title=\"Protein: Solute carrier family 2, facilitated glucose transporter member 4 [Mus musculus]\">Solute carrier family 2, facilitated glucose transporter member 4<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:4bf89347-f025-49a3-b1b6-46ff7a96260c\" title=\"Protein: Insulin receptor precursor [Mus musculus]\">Insulin receptor precursor<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e02dc3a7-d334-4ba4-9474-5dadce8ca9f6\" title=\"Protein: Microtubule-associated protein tau [Mus musculus]\">Microtubule-associated protein tau<\/a>; ","relatedToOthers":"true","title":"Insulin resistance plays a role in brain aging and increases the risk of AD and vascular dementia.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a546d499-f61c-4a24-abbd-358392734ffc&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a546d499-f61c-4a24-abbd-358392734ffc&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:a546d499-f61c-4a24-abbd-358392734ffc","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a546d499-f61c-4a24-abbd-358392734ffc&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Signaling mechanisms play a critical role in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":8,"containedwithoutevidence":0,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a546d499-f61c-4a24-abbd-358392734ffc&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:a546d499-f61c-4a24-abbd-358392734ffc","containedwithevidence":32,"type":"Hypothesis","contained":32,"status":"Extended Annotation","referenceDate":"2009-10-29","containedevidencecount":45,"alternativeto":4,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a546d499-f61c-4a24-abbd-358392734ffc&referrerLinkLabel=hypothesislist","label":"Craft S; Insulin resistance plays a role in brain...","firstAuthor":"Craft S"},{"lsid":"urn:lsid:swan.org:researchstatement:bac46b16-b635-4f94-a335-da8cd3f6854c","title":"The progressive accumulation of altered tau protein results in instability of microtubules in neurons in Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1986-06","id":"urn:lsid:swan.org:researchstatement:bac46b16-b635-4f94-a335-da8cd3f6854c","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bac46b16-b635-4f94-a335-da8cd3f6854c&referrerLinkLabel=hypothesislist","label":"Kosik K et al.; The progressive accumulation of altered ...","HotTopics":["Failure of axonal transport might be the underlying basis for neurodegeneration in Alzheimer Disease","Tau dysfunction mediates neurodegeneration"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Joachim C L","Selkoe D J"],"firstAuthor":"Kosik K S","taxonomy":["Cytoskeletal Proteins"],"referenceYear":"1986"},{"containedwithevidence":32,"lsid":"urn:lsid:swan.org:researchstatement:260252b5-99ac-4577-95c4-0f78c50708a9","title":"NMDA receptor hypoactivity (NRHypo) may have an important contributory role in Alzheimer disease.","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:260252b5-99ac-4577-95c4-0f78c50708a9&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":32,"status":"Extended Annotation","referenceDate":"1997-10","id":"urn:lsid:swan.org:researchstatement:260252b5-99ac-4577-95c4-0f78c50708a9","containedevidencecount":41,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:260252b5-99ac-4577-95c4-0f78c50708a9&referrerLinkLabel=hypothesislist","label":"Olney J et al.; NMDA receptor hypoactivity (NRHypo) may ...","HotTopics":["Signaling mechanisms play a critical role in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Wozniak D F","Farber N B"],"containedwithoutevidence":0,"firstAuthor":"Olney J W","taxonomy":["Synapses"],"referenceYear":"1997","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:260252b5-99ac-4577-95c4-0f78c50708a9&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsid":"urn:lsid:swan.org:researchstatement:9eaa47e3-5550-4839-8fbb-840c2eaa5f13","title":"Cholinergic-Vascular Hypothesis of Alzheimer Disease:  Cholinesterase inhibitors augment cerebral perfusion.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2006-03","id":"urn:lsid:swan.org:researchstatement:9eaa47e3-5550-4839-8fbb-840c2eaa5f13","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:9eaa47e3-5550-4839-8fbb-840c2eaa5f13&referrerLinkLabel=hypothesislist","label":"Claassen J et al.; Cholinergic-Vascular Hypothesis of Alzhe...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Jansen René W"],"firstAuthor":"Claassen Jurgen A","taxonomy":["Synapses"],"referenceYear":"2006"},{"lsid":"urn:lsid:swan.org:researchstatement:cc02a78e-75d6-4ead-860f-a39ff81fcdff","title":"Systems-level organization of cholinergic innervation is altered in Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1996","id":"urn:lsid:swan.org:researchstatement:cc02a78e-75d6-4ead-860f-a39ff81fcdff","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:cc02a78e-75d6-4ead-860f-a39ff81fcdff&referrerLinkLabel=hypothesislist","label":"Mesulam M; Systems-level organization of cholinergi...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Synaptic loss appears to be the most powerful and ubiquitous proximate factor leading to the dementia of Alzheimer Disease"],"firstAuthor":"Mesulam M M","taxonomy":["Synapses"],"referenceYear":"1996"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:9449c4a8-ef5c-4082-bb7d-0b2a3e3972bb\" title=\"Protein: Proto-oncogene tyrosine-protein kinase Fyn [Homo sapiens]\">Proto-oncogene tyrosine-protein kinase Fyn<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7f16becf-01b1-406c-8267-e26208a21c5d&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Oligomeric amyloid beta ligands (ADDLs) are a molecular basis for reversible memory loss.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7f16becf-01b1-406c-8267-e26208a21c5d&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":6,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7f16becf-01b1-406c-8267-e26208a21c5d&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:7f16becf-01b1-406c-8267-e26208a21c5d","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7f16becf-01b1-406c-8267-e26208a21c5d&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Soluble oligomeric aggregates of Aβ are toxic to neurons and cause AD pathology","Synaptic loss appears to be the most powerful and ubiquitous proximate factor leading to the dementia of Alzheimer Disease"],"supportedby":20,"containedwithoutevidence":0,"taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"2003","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7f16becf-01b1-406c-8267-e26208a21c5d&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:7f16becf-01b1-406c-8267-e26208a21c5d","containedwithevidence":46,"type":"Hypothesis","contained":46,"status":"Extended Annotation","referenceDate":"2003-09-02","containedevidencecount":106,"alternativeto":7,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7f16becf-01b1-406c-8267-e26208a21c5d&referrerLinkLabel=hypothesislist","label":"Gong Y et al.; Oligomeric amyloid beta ligands (ADDLs) ...","otherAuthors":["Chang Lei","Lambert Mary P","Klein W L","Lacor Pascale N","Finch Caleb E","Krafft Grant A","Viola Kirsten L"],"firstAuthor":"Gong Yuesong"},{"lsid":"urn:lsid:swan.org:researchstatement:308e22f4-bb35-468d-805a-45307c30470c","title":"CNS synaptogenesis promoted by glia-derived cholesterol complexed to ApoE.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2001-11-09","id":"urn:lsid:swan.org:researchstatement:308e22f4-bb35-468d-805a-45307c30470c","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:308e22f4-bb35-468d-805a-45307c30470c&referrerLinkLabel=hypothesislist","label":"Mauch D et al.; CNS synaptogenesis promoted by glia-deri...","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Nägler K","Schumacher S","Göritz C","Müller E C","Otto A","Pfrieger F W"],"firstAuthor":"Mauch D H","taxonomy":["ApoE"],"referenceYear":"2001"},{"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:cfb36861-2078-4574-bd17-cafabb2fda01&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:cfb36861-2078-4574-bd17-cafabb2fda01","type":"Hypothesis","title":"Alzheimer disease is identified by plaques and tangles in the brain.","label":"Alzheimer A; Alzheimer disease is identified by plaqu...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","status":"Simple Annotation","firstAuthor":"Alzheimer Alois","id":"urn:lsid:swan.org:researchstatement:cfb36861-2078-4574-bd17-cafabb2fda01"},{"lsid":"urn:lsid:swan.org:researchstatement:4a60cd69-94db-493d-82a8-65e3d2a981b2","title":"Cardiovascular Hypothesis of Alzheimer Disease:  Heart disease may be a forerunner to Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1990","id":"urn:lsid:swan.org:researchstatement:4a60cd69-94db-493d-82a8-65e3d2a981b2","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4a60cd69-94db-493d-82a8-65e3d2a981b2&referrerLinkLabel=hypothesislist","label":"Sparks D et al.; Cardiovascular Hypothesis of Alzheimer D...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Hunsaker J C","Scheff S W","Kryscio R J","Henson J L","Markesbery W R"],"firstAuthor":"Sparks D L","taxonomy":["Trophic Factors"],"referenceYear":"1990"},{"lsid":"urn:lsid:swan.org:researchstatement:02a5b0f4-1476-4de9-a931-da7e418c5327","title":"The mitochondrial cascade hypothesis focuses on the electron transport chain as establishing basal rate of reactive oxygen species production and induction of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2004","id":"urn:lsid:swan.org:researchstatement:02a5b0f4-1476-4de9-a931-da7e418c5327","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:02a5b0f4-1476-4de9-a931-da7e418c5327&referrerLinkLabel=hypothesislist","label":"Swerdlow R et al.; The mitochondrial cascade hypothesis foc...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Khan Shaharyar M"],"firstAuthor":"Swerdlow Russell H","taxonomy":["Metabolism"],"referenceYear":"2004"},{"lsid":"urn:lsid:swan.org:researchstatement:05216206-bfb5-4634-890d-f3ad0c854e51","title":"ApoE4 enhances amyloid deposition.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1992-02-03","id":"urn:lsid:swan.org:researchstatement:05216206-bfb5-4634-890d-f3ad0c854e51","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:05216206-bfb5-4634-890d-f3ad0c854e51&referrerLinkLabel=hypothesislist","label":"Wisniewski T et al.; ApoE4 enhances amyloid deposition.","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Frangione B"],"firstAuthor":"Wisniewski T","taxonomy":["ApoE"],"referenceYear":"1992"},{"lsid":"urn:lsid:swan.org:researchstatement:534caab4-5137-46a0-ae6d-db360eda7492","title":"RAGE receptor binds Aβ peptides and mediates Aβ effects on neurons and microglia.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1996-08-22","id":"urn:lsid:swan.org:researchstatement:534caab4-5137-46a0-ae6d-db360eda7492","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:534caab4-5137-46a0-ae6d-db360eda7492&referrerLinkLabel=hypothesislist","label":"Yan S et al.; RAGE receptor binds Aβ peptides and medi...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Chen X","Fu J","Chen M","Zhu H","Roher A","Slattery T","Zhao L","Nagashima M","Morser J","Migheli A","Nawroth P","Stern D","Schmidt A M"],"firstAuthor":"Yan S D","taxonomy":["Oxidation"],"referenceYear":"1996"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d1b70427-57d3-4d6d-951d-9fc185717d9c\" title=\"Protein: Alpha-synuclein [Homo sapiens]\">Alpha-synuclein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a941dccb-b1b7-474b-ad3d-01a571beb52e\" title=\"Protein: TAR DNA-binding protein 43 [Homo sapiens]\">TAR DNA-binding protein 43<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>; ","containedwithevidence":16,"lsid":"urn:lsid:swan.org:researchstatement:ca33ab40-0cc9-4686-b3fc-a5cfa47105b5","title":"[ADNI]  Decreased cerebrospinal fluid (CSF) Aβ42 and positive Pittsburgh compound B amyloid imaging are early pathological changes in AD.","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ca33ab40-0cc9-4686-b3fc-a5cfa47105b5&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":16,"status":"Extended Annotation","id":"urn:lsid:swan.org:researchstatement:ca33ab40-0cc9-4686-b3fc-a5cfa47105b5","containedevidencecount":36,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ca33ab40-0cc9-4686-b3fc-a5cfa47105b5&referrerLinkLabel=hypothesislist","label":"Jack C et al.; [ADNI]  Decreased cerebrospinal fluid (C...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Biomarkers are useful for predicting and staging Alzheimer disease"],"otherAuthors":["Knopman David S","Jagust William J","Shaw Leslie M","Aisen Paul S","Weiner M","Petersen Ronald C","Trojanowski John Q"],"containedwithoutevidence":0,"firstAuthor":"Jack Clifford R","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ca33ab40-0cc9-4686-b3fc-a5cfa47105b5&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsid":"urn:lsid:swan.org:researchstatement:ffdc2121-2a67-490e-9c00-d616f39697cc","title":"The accumulation of synthetic or native Alzheimer\u2019s disease (AD)-brain oligomers at synapses is regulated by synaptic activity and zinc.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2009-04-01","id":"urn:lsid:swan.org:researchstatement:ffdc2121-2a67-490e-9c00-d616f39697cc","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ffdc2121-2a67-490e-9c00-d616f39697cc&referrerLinkLabel=hypothesislist","label":"Deshpande A et al.; The accumulation of synthetic or native ...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Kawai Hideki","Metherate Raju","Glabe Charles G","Busciglio Jorge"],"firstAuthor":"Deshpande Atul","referenceYear":"2009"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:607f4fa6-5204-44ac-81c5-b3957f9f2855\" title=\"Gene: MAPT microtubule-associated protein tau [Homo sapiens]\">MAPT<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a9e26e44-08c6-45f3-9dfb-d386feab0b55\" title=\"Protein: Presenilin-2 [Homo sapiens]\">Presenilin-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:cfdaa5e5-f0e7-43f1-9347-558c2044dee8\" title=\"Gene: PSEN2 presenilin 2 (Alzheimer disease 4) [Homo sapiens]\">PSEN2<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e02dc3a7-d334-4ba4-9474-5dadce8ca9f6\" title=\"Protein: Microtubule-associated protein tau [Mus musculus]\">Microtubule-associated protein tau<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4e479be3-a374-4b5f-a23a-f28f1b8285c7&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4e479be3-a374-4b5f-a23a-f28f1b8285c7&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"A critical reappraisal of the Amyloid Hypothesis, in response to inconclusive clinical trial results.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4e479be3-a374-4b5f-a23a-f28f1b8285c7&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":2,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4e479be3-a374-4b5f-a23a-f28f1b8285c7&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:4e479be3-a374-4b5f-a23a-f28f1b8285c7","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4e479be3-a374-4b5f-a23a-f28f1b8285c7&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Aβ accumulation in the brain is the primary event in Alzheimer Disease pathogenesis"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":4,"containedwithoutevidence":1,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4e479be3-a374-4b5f-a23a-f28f1b8285c7&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:4e479be3-a374-4b5f-a23a-f28f1b8285c7","containedwithevidence":24,"type":"Hypothesis","contained":25,"status":"Extended Annotation","referenceDate":"2009-05-18","containedevidencecount":83,"alternativeto":2,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4e479be3-a374-4b5f-a23a-f28f1b8285c7&referrerLinkLabel=hypothesislist","label":"Hardy J; A critical reappraisal of the Amyloid Hy...","firstAuthor":"Hardy John"},{"lsid":"urn:lsid:swan.org:researchstatement:9777c50e-3273-4e01-a8de-e1ea9cdf6a48","title":"Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2004-12","id":"urn:lsid:swan.org:researchstatement:9777c50e-3273-4e01-a8de-e1ea9cdf6a48","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:9777c50e-3273-4e01-a8de-e1ea9cdf6a48&referrerLinkLabel=hypothesislist","label":"Miklossy J et al.; Borrelia burgdorferi persists in the bra...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Khalili Kamel","Gern Lise","Ericson Rebecca L","Darekar Pushpa","Bolle Lorie","Hurlimann Jean","Paster Bruce J"],"firstAuthor":"Miklossy Judith","taxonomy":["Oxidation"],"referenceYear":"2004"},{"lsid":"urn:lsid:swan.org:researchstatement:896014e2-4cf4-42a2-9852-a8ad5dee074a","title":"Loss of glucose transporter at blood brain barrier, in cerebral microvessels and cortex is specific and disease-related in Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1989","id":"urn:lsid:swan.org:researchstatement:896014e2-4cf4-42a2-9852-a8ad5dee074a","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:896014e2-4cf4-42a2-9852-a8ad5dee074a&referrerLinkLabel=hypothesislist","label":"Kalaria R et al.; Loss of glucose transporter at blood bra...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Harik S I"],"firstAuthor":"Kalaria R N","taxonomy":["Circulation"],"referenceYear":"1989"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b090c7bd-adb2-4b3b-9bea-06ae7dbb5800&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b090c7bd-adb2-4b3b-9bea-06ae7dbb5800&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer\u2019s disease.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b090c7bd-adb2-4b3b-9bea-06ae7dbb5800&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":10,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b090c7bd-adb2-4b3b-9bea-06ae7dbb5800&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:b090c7bd-adb2-4b3b-9bea-06ae7dbb5800","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b090c7bd-adb2-4b3b-9bea-06ae7dbb5800&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Insoluble fibrillar Aβ leads to AD"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":15,"containedwithoutevidence":3,"referenceYear":"2008","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b090c7bd-adb2-4b3b-9bea-06ae7dbb5800&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:b090c7bd-adb2-4b3b-9bea-06ae7dbb5800","containedwithevidence":37,"type":"Hypothesis","contained":40,"status":"Extended Annotation","referenceDate":"2008-02-07","containedevidencecount":54,"alternativeto":13,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b090c7bd-adb2-4b3b-9bea-06ae7dbb5800&referrerLinkLabel=hypothesislist","label":"Meyer-Luehmann M et al.; Rapid appearance and local toxicity of a...","otherAuthors":["Spires-Jones Tara L","Prada Claudia","Garcia-Alloza Monica","de Calignon Alix","Rozkalne Anete","Koenigsknecht-Talboo Jessica","Holtzman David M","Bacskai Brian J","Hyman Bradley T"],"firstAuthor":"Meyer-Luehmann Melanie"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:031a230d-7cb3-45c0-94f7-a7b608724b4d\" title=\"Protein: Nicastrin [Homo sapiens]\">Nicastrin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c8029a6-bdff-4298-a726-9d323d5cf326\" title=\"Protein: Gamma-secretase subunit PEN-2 [Homo sapiens]\">Gamma-secretase subunit PEN-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:45dccdee-f207-4e31-9cd2-83bf74aada5e\" title=\"Protein: Gamma-secretase subunit APH-1A [Homo sapiens]\">Gamma-secretase subunit APH-1A<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a9e26e44-08c6-45f3-9dfb-d386feab0b55\" title=\"Protein: Presenilin-2 [Homo sapiens]\">Presenilin-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bfa41ff8-d31b-4b89-9d67-83cb5fda3244&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bfa41ff8-d31b-4b89-9d67-83cb5fda3244&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"PS1 clinical mutations can affect γ-secretase activity by different mechanisms.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bfa41ff8-d31b-4b89-9d67-83cb5fda3244&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":3,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bfa41ff8-d31b-4b89-9d67-83cb5fda3244&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:bfa41ff8-d31b-4b89-9d67-83cb5fda3244","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bfa41ff8-d31b-4b89-9d67-83cb5fda3244&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Changes in presenilin function lead to dementia and neurodegeneration in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":18,"containedwithoutevidence":25,"referenceYear":"2006","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bfa41ff8-d31b-4b89-9d67-83cb5fda3244&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:bfa41ff8-d31b-4b89-9d67-83cb5fda3244","containedwithevidence":21,"type":"Hypothesis","contained":46,"status":"Extended Annotation","referenceDate":"2006-02","containedevidencecount":49,"alternativeto":9,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bfa41ff8-d31b-4b89-9d67-83cb5fda3244&referrerLinkLabel=hypothesislist","label":"Bentahir M et al.; PS1 clinical mutations can affect γ-secr...","otherAuthors":["Nyabi Omar","Verhamme Jan","Tolia Alexandra","Horré Katrien","Wiltfang Jens","Esselmann Hermann","De Strooper Bart"],"firstAuthor":"Bentahir Mostafa"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>; ","relatedToOthers":"true","title":"Amyloid-β protein dimers isolated directly from Alzheimer\u2019s brains impair synaptic plasticity and memory","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7a61463a-f527-44d6-95fc-916bdd3fc998&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7a61463a-f527-44d6-95fc-916bdd3fc998&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:7a61463a-f527-44d6-95fc-916bdd3fc998","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7a61463a-f527-44d6-95fc-916bdd3fc998&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Insoluble fibrillar Aβ leads to AD"],"supportedby":6,"containedwithoutevidence":0,"taxonomy":["Protein Processing"],"referenceYear":"2008","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7a61463a-f527-44d6-95fc-916bdd3fc998&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:7a61463a-f527-44d6-95fc-916bdd3fc998","containedwithevidence":16,"type":"Hypothesis","contained":16,"status":"Extended Annotation","referenceDate":"2008-08","containedevidencecount":44,"alternativeto":1,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7a61463a-f527-44d6-95fc-916bdd3fc998&referrerLinkLabel=hypothesislist","label":"Shankar G et al.; Amyloid-β protein dimers isolated direct...","otherAuthors":["Li Shaomin","Mehta Tapan H","Garcia-Munoz Amaya","Shepardson Nina E","Smith Imelda","Brett Francesca M","Farrell Michael A","Rowan Michael J","Lemere Cynthia A","Regan Ciaran M","Walsh Dominic M","Sabatini Bernardo L","Selkoe Dennis J"],"firstAuthor":"Shankar Ganesh M"},{"lsid":"urn:lsid:swan.org:researchstatement:19dcd37f-dfbc-4672-b34b-497220d6f9e7","title":"ApoJ/Clusterin contributes to chronic inflammation and neurotoxicity through direct effects on microglia.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2005-05","id":"urn:lsid:swan.org:researchstatement:19dcd37f-dfbc-4672-b34b-497220d6f9e7","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:19dcd37f-dfbc-4672-b34b-497220d6f9e7&referrerLinkLabel=hypothesislist","label":"Xie Z et al.; ApoJ/Clusterin contributes to chronic in...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Harris-White M E","Wals P A","Frautschy S A","Finch C E","Morgan T E"],"firstAuthor":"Xie Z","taxonomy":["Trophic Factors"],"referenceYear":"2005"},{"lsid":"urn:lsid:swan.org:researchstatement:8db50dcd-bf60-489a-8f34-eabc727c97e7","title":"Blood-Brain Barrier and Alzheimer Disease: Pathogenesis of Alzheimer disease begins with a leakage of a neurotoxin through a defective cortical blood brain barrier.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1985-09","id":"urn:lsid:swan.org:researchstatement:8db50dcd-bf60-489a-8f34-eabc727c97e7","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8db50dcd-bf60-489a-8f34-eabc727c97e7&referrerLinkLabel=hypothesislist","label":"Mann D; Blood-Brain Barrier and Alzheimer Diseas...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","firstAuthor":"Mann D M","taxonomy":["Circulation"],"referenceYear":"1985"},{"lsid":"urn:lsid:swan.org:researchstatement:f5a9bc13-220d-4cdb-92a3-efb058c8fc93","title":"Estrogen use in postmenopausal women may delay the onset and decrease the risk of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1996-08-17","id":"urn:lsid:swan.org:researchstatement:f5a9bc13-220d-4cdb-92a3-efb058c8fc93","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f5a9bc13-220d-4cdb-92a3-efb058c8fc93&referrerLinkLabel=hypothesislist","label":"Tang M et al.; Estrogen use in postmenopausal women may...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Jacobs D","Stern Y","Marder K","Schofield P","Gurland B","Andrews H","Mayeux R"],"firstAuthor":"Tang M X","taxonomy":["Hormones"],"referenceYear":"1996"},{"lsid":"urn:lsid:swan.org:researchstatement:393d0393-87f6-4772-966f-d91922d1eb74","title":"ApoE scavenger receptor BI binds ApoE complexed Aβ.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2002-04-15","id":"urn:lsid:swan.org:researchstatement:393d0393-87f6-4772-966f-d91922d1eb74","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:393d0393-87f6-4772-966f-d91922d1eb74&referrerLinkLabel=hypothesislist","label":"Srivastava R et al.; ApoE scavenger receptor BI binds ApoE co...","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Jain Jinesh C"],"firstAuthor":"Srivastava Rai Ajit","taxonomy":["ApoE"],"referenceYear":"2002"},{"lsid":"urn:lsid:swan.org:researchstatement:d9ac7aed-c395-4775-b38f-282afc8ac64a","title":"MHC-I signaling is important in the development, function, and diseases of both immune and nervous systems.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2001-10","id":"urn:lsid:swan.org:researchstatement:d9ac7aed-c395-4775-b38f-282afc8ac64a","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d9ac7aed-c395-4775-b38f-282afc8ac64a&referrerLinkLabel=hypothesislist","label":"Boulanger L et al.; MHC-I signaling is important in the deve...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Huh G S","Shatz C J"],"firstAuthor":"Boulanger L M","taxonomy":["Inflammation"],"referenceYear":"2001"},{"lsid":"urn:lsid:swan.org:researchstatement:ddfc4a6b-d6d8-4d73-991e-6c9b53bf58de","title":"Neuroplasticity failure is the core of a unifying theory that can account for all the clinical and neuropathological features of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1999-11","id":"urn:lsid:swan.org:researchstatement:ddfc4a6b-d6d8-4d73-991e-6c9b53bf58de","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ddfc4a6b-d6d8-4d73-991e-6c9b53bf58de&referrerLinkLabel=hypothesislist","label":"Mesulam M; Neuroplasticity failure is the core of a...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Synaptic loss appears to be the most powerful and ubiquitous proximate factor leading to the dementia of Alzheimer Disease"],"firstAuthor":"Mesulam M M","taxonomy":["Synapses"],"referenceYear":"1999"},{"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:beab2259-90d6-41a4-b49a-6a6a11c381e4&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:beab2259-90d6-41a4-b49a-6a6a11c381e4","type":"Hypothesis","title":"Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down's syndrome patients.","label":"van Leeuwen F; Frameshift mutants of beta amyloid precu...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","status":"Simple Annotation","firstAuthor":"van Leeuwen F W","id":"urn:lsid:swan.org:researchstatement:beab2259-90d6-41a4-b49a-6a6a11c381e4"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:95fd1cff-b1a2-4d0d-9e71-317e9fd8f1de\" title=\"Gene: PICALM phosphatidylinositol binding clathrin assembly protein [Homo sapiens]\">PICALM<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:dc39c47e-1e5c-4253-a762-9f9e558919fe\" title=\"Protein: Clusterin [Homo sapiens]\">Clusterin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:d4e70f4a-d0fd-4c63-ac0e-16b07d929b28\" title=\"Gene: CLU clusterin [Homo sapiens]\">CLU<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:4bf6dbf5-da0e-4527-ba23-33cd7d15b56b\" title=\"Gene: BIN1 bridging integrator 1 [Homo sapiens]\">BIN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:1bb91b97-c33a-43b8-8abf-e6c4f4deeee8\" title=\"Gene: DAB1 disabled homolog 1 (Drosophila) [Homo sapiens]\">DAB1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:52d9d0a5-272d-49aa-a084-86ef6fa06253\" title=\"Protein: Vesicle-associated membrane protein 2 [Homo sapiens]\">Vesicle-associated membrane protein 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:beb73abe-e850-4182-998e-a7a847447b41\" title=\"Protein: Apolipoprotein E [Homo sapiens]\">Apolipoprotein E<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:cfce1d58-2232-4a9f-aa66-0e0f83f4161a\" title=\"Protein: Myc box-dependent-interacting protein 1 [Homo sapiens]\">Myc box-dependent-interacting protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b3e235dc-a69e-4847-b637-d1a4d4d8b842\" title=\"Protein: Phosphatidylinositol-binding clathrin assembly protein [Homo sapiens]\">Phosphatidylinositol-binding clathrin assembly protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:c97485d8-7ae3-4313-8d36-6246cd9318ff\" title=\"Gene: CR1 complement component (3b/4b) receptor 1 (Knops blood group) [Homo sapiens]\">CR1<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:ea72cb67-bf1c-47d4-aac7-3c5ec7406a90\" title=\"Protein: Phosphatidylinositol-binding clathrin assembly protein [Mus musculus]\">Phosphatidylinositol-binding clathrin assembly protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:6598311f-a15b-4b73-bbed-9b538bf2244f\" title=\"Gene: Picalm phosphatidylinositol binding clathrin assembly protein [Mus musculus]\">Picalm<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:7ae18db6-0112-4cb6-8ce0-95d78cc057ba\" title=\"Protein: Vesicle-associated membrane protein 2 [Mus musculus]\">Vesicle-associated membrane protein 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:bddfcbef-c040-444d-b93b-a4ceee2979cc\" title=\"Protein: Myc box-dependent-interacting protein 1 [Mus musculus]\">Myc box-dependent-interacting protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:2b85a486-a158-4ecf-9e91-495548bbf226\" title=\"Gene: Cr2 complement receptor 2 [Mus musculus]\">Cr2<\/a>; ","relatedToOthers":"true","title":"Clusterin (ApoJ) and phosphatidylinositol binding clathrin assembly protein gene (PICALM) genes are associated with Late Onset AD.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c38f0b6b-2328-4545-bf2d-6dff5309aeb2&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c38f0b6b-2328-4545-bf2d-6dff5309aeb2&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:c38f0b6b-2328-4545-bf2d-6dff5309aeb2","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c38f0b6b-2328-4545-bf2d-6dff5309aeb2&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Genetic variants modulate risk of AD"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":3,"containedwithoutevidence":0,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c38f0b6b-2328-4545-bf2d-6dff5309aeb2&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:c38f0b6b-2328-4545-bf2d-6dff5309aeb2","containedwithevidence":19,"type":"Hypothesis","contained":19,"status":"Extended Annotation","referenceDate":"2009-10","containedevidencecount":46,"alternativeto":1,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c38f0b6b-2328-4545-bf2d-6dff5309aeb2&referrerLinkLabel=hypothesislist","label":"Harold D et al.; Clusterin (ApoJ) and phosphatidylinosito...","otherAuthors":["Abraham Richard","Hollingworth Paul","Sims Rebecca","Gerrish Amy","Hamshere Marian L","Pahwa Jaspreet Singh","Moskvina Valentina","Dowzell Kimberley","Williams Amy","Jones Nicola","Thomas Charlene","Stretton Alexandra","Morgan Angharad R","Lovestone Simon","Powell John","Proitsi Petroula","Lupton Michelle K","Brayne Carol","Rubinsztein David C","Gill Michael","Lawlor Brian","Lynch Aoibhinn","Morgan Kevin","Brown Kristelle S","Passmore Peter A","Craig David","McGuinness Bernadette","Todd Stephen","Holmes Clive","Mann David","Smith A David","Love Seth","Kehoe Patrick G","Hardy John","Mead Simon","Fox Nick","Rossor Martin","Collinge John","Maier Wolfgang","Jessen Frank","Schürmann Britta","van den Bussche Hendrik","Heuser Isabella","Kornhuber Johannes","Wiltfang Jens","Dichgans Martin","Frölich Lutz","Hampel Harald","Hüll Michael","Rujescu Dan","Goate Alison M","Kauwe John S","Cruchaga Carlos","Nowotny Petra","Morris John C","Mayo Kevin","Sleegers Kristel","Bettens Karolien","Engelborghs Sebastiaan","De Deyn Peter P","Van Broeckhoven Christine","Livingston Gill","Bass Nicholas J","Gurling Hugh","McQuillin Andrew","Gwilliam Rhian","Deloukas Panagiotis","Al-Chalabi Ammar","Shaw Christopher E","Tsolaki Magda","Singleton Andrew B","Guerreiro Rita","Mühleisen Thomas W","Nöthen Markus M","Moebus Susanne","Jöckel Karl-Heinz","Klopp Norman","Wichmann H-Erich","Carrasquillo Minerva M","Pankratz V Shane","Younkin Steven G","Holmans Peter A","O'Donovan Michael","Owen Michael J","Williams Julie"],"firstAuthor":"Harold Denise"},{"lsid":"urn:lsid:swan.org:researchstatement:4f175542-9785-48d9-887a-2001e4420cda","title":"Cholesterol transport alters PS1 localization and APP processing.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2002-03-01","id":"urn:lsid:swan.org:researchstatement:4f175542-9785-48d9-887a-2001e4420cda","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4f175542-9785-48d9-887a-2001e4420cda&referrerLinkLabel=hypothesislist","label":"Runz H et al.; Cholesterol transport alters PS1 localiz...","HotTopics":["Changes in presenilin function lead to dementia and neurodegeneration in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Rietdorf Jens","Tomic Inge","de Bernard Marina","Beyreuther Konrad","Pepperkok Rainer","Hartmann Tobias"],"firstAuthor":"Runz Heiko","taxonomy":["Protein Processing"],"referenceYear":"2002"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:62b16732-5468-4798-9565-249ed24183af\" title=\"Gene: IDE insulin-degrading enzyme [Homo sapiens]\">IDE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:46a93973-ff08-4203-ae84-d50aeb4141b4\" title=\"Protein: Insulin-degrading enzyme [Homo sapiens]\">Insulin-degrading enzyme<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:6f8871ee-982e-4d26-a0f7-052d3367732c&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:6f8871ee-982e-4d26-a0f7-052d3367732c&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":2,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:6f8871ee-982e-4d26-a0f7-052d3367732c&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:6f8871ee-982e-4d26-a0f7-052d3367732c","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:6f8871ee-982e-4d26-a0f7-052d3367732c&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Soluble oligomeric aggregates of Aβ are toxic to neurons and cause AD pathology"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":16,"discussedby":1,"containedwithoutevidence":0,"referenceYear":"2002","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:6f8871ee-982e-4d26-a0f7-052d3367732c&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:6f8871ee-982e-4d26-a0f7-052d3367732c","containedwithevidence":28,"type":"Hypothesis","contained":28,"status":"Extended Annotation","referenceDate":"2002-04-04","containedevidencecount":62,"discussedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:6f8871ee-982e-4d26-a0f7-052d3367732c&selectContainedDiscourseElementCriteria=discussedByOtherDiscourseElements&referrerLinkLabel=hypothesislist","alternativeto":4,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:6f8871ee-982e-4d26-a0f7-052d3367732c&referrerLinkLabel=hypothesislist","label":"Walsh D et al.; Naturally secreted oligomers of amyloid ...","otherAuthors":["Klyubin Igor","Fadeeva Julia V","Cullen William K","Anwyl Roger","Wolfe Michael S","Rowan Michael J","Selkoe Dennis J"],"firstAuthor":"Walsh Dominic M"},{"lsid":"urn:lsid:swan.org:researchstatement:245d9c42-0a04-4d4e-b2b8-51d506079e4d","title":"ApoE aggregates have isoform-specific neurotoxicity.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2006-09-01","id":"urn:lsid:swan.org:researchstatement:245d9c42-0a04-4d4e-b2b8-51d506079e4d","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:245d9c42-0a04-4d4e-b2b8-51d506079e4d&referrerLinkLabel=hypothesislist","label":"Hatters D et al.; ApoE aggregates have isoform-specific ne...","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Zhong Ning","Rutenber Earl","Weisgraber Karl H"],"firstAuthor":"Hatters Danny M","taxonomy":["ApoE"],"referenceYear":"2006"},{"lsid":"urn:lsid:swan.org:researchstatement:f19c9b3a-36b6-4f47-a870-04283f7899c5","title":"Aging-related changes in metabolism lead to neurodegeneration.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1997-01","id":"urn:lsid:swan.org:researchstatement:f19c9b3a-36b6-4f47-a870-04283f7899c5","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f19c9b3a-36b6-4f47-a870-04283f7899c5&referrerLinkLabel=hypothesislist","label":"Finch C et al.; Aging-related changes in metabolism lead...","HotTopics":["The molecular mechanisms of neuronal cell death are involved in the dysfunction and death of neurons in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Cohen D M"],"firstAuthor":"Finch C E","taxonomy":["Metabolism"],"referenceYear":"1997"},{"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:89585d70-7a66-4b8d-91ee-16cdd81450e4&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:89585d70-7a66-4b8d-91ee-16cdd81450e4","type":"Hypothesis","title":"The combination of nicotine with galantamine is expected to have enhanced therapeutic effects in patients with Alzheimer's disease.","label":"Petrova S; The combination of nicotine with galanta...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","status":"Simple Annotation","firstAuthor":"Petrova Silvia","id":"urn:lsid:swan.org:researchstatement:89585d70-7a66-4b8d-91ee-16cdd81450e4"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:72bbbada-3024-443b-8c07-cd2b74de176c\" title=\"Protein: C99 [Homo sapiens]\">C99<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:87fd6477-4c25-4086-8a6c-2b376ec86eed\" title=\"Protein: Beta-secretase 1 [Mus musculus]\">Beta-secretase 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:554d2b75-a595-4759-affc-8941d94e90df\" title=\"Gene: Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 [Mus musculus]\">Cyp19a1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:79dd6cf7-7c8e-4d10-a536-732d98b53a9e\" title=\"Protein: Neprilysin [Mus musculus]\">Neprilysin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:90602c00-8d81-48c6-a5c1-8d929394c903\" title=\"Protein: Insulin-degrading enzyme [Mus musculus]\">Insulin-degrading enzyme<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:d789554a-ffd2-4af5-a899-de2a05defcee\" title=\"Gene: Bace1 beta-site APP cleaving enzyme 1 [Mus musculus]\">Bace1<\/a>; ","containedwithevidence":10,"lsid":"urn:lsid:swan.org:researchstatement:f55ee608-4ea1-4bdf-95b7-3c59b42229e2","title":"Genetic depletion of aromatase in male APP transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. ","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f55ee608-4ea1-4bdf-95b7-3c59b42229e2&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":10,"status":"Extended Annotation","referenceDate":"2010-05-26","id":"urn:lsid:swan.org:researchstatement:f55ee608-4ea1-4bdf-95b7-3c59b42229e2","containedevidencecount":18,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f55ee608-4ea1-4bdf-95b7-3c59b42229e2&referrerLinkLabel=hypothesislist","label":"McAllister C et al.; Genetic depletion of aromatase in male A...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Long Jiangang","Bowers Adrienne","Walker Aaron","Cao Philip","Honda Shin-Ichiro","Harada Nobuhiro","Staufenbiel Matthias","Shen Yong","Li Rena"],"containedwithoutevidence":0,"firstAuthor":"McAllister Carrie","referenceYear":"2010","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f55ee608-4ea1-4bdf-95b7-3c59b42229e2&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsid":"urn:lsid:swan.org:researchstatement:028e69e8-4439-4b79-a3e7-18391cf6e4aa","title":"The decreased antioxidant activity of ApoE4 could contribute to Alzheimer disease, cardiovascular disease and decreased longevity.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1996-09","id":"urn:lsid:swan.org:researchstatement:028e69e8-4439-4b79-a3e7-18391cf6e4aa","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:028e69e8-4439-4b79-a3e7-18391cf6e4aa&referrerLinkLabel=hypothesislist","label":"Miyata M et al.; The decreased antioxidant activity of Ap...","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Smith J D"],"firstAuthor":"Miyata M","taxonomy":["ApoE"],"referenceYear":"1996"},{"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f1632976-dc86-414e-9450-8dfdf07bd63e&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:f1632976-dc86-414e-9450-8dfdf07bd63e","type":"Hypothesis","title":"Oxidative stress is central to the pathogenesis of Alzheimer's disease.","label":"Smith M et al.; Oxidative stress is central to the patho...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Perry George"],"status":"Simple Annotation","firstAuthor":"Smith Mark A","id":"urn:lsid:swan.org:researchstatement:f1632976-dc86-414e-9450-8dfdf07bd63e"},{"lsid":"urn:lsid:swan.org:researchstatement:bd5b25a1-dd73-4ecb-8a8a-c50d3ad8ca5b","title":"Cholesterol homeostasis failure as a unifying cause of synaptic degeneration.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2005-03-15","id":"urn:lsid:swan.org:researchstatement:bd5b25a1-dd73-4ecb-8a8a-c50d3ad8ca5b","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bd5b25a1-dd73-4ecb-8a8a-c50d3ad8ca5b&referrerLinkLabel=hypothesislist","label":"Koudinov A et al.; Cholesterol homeostasis failure as a uni...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Koudinova Natalia V"],"firstAuthor":"Koudinov Alexei R","referenceYear":"2005"},{"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:cc9e4a2f-490f-4870-a649-265fcde91823&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:cc9e4a2f-490f-4870-a649-265fcde91823","type":"Hypothesis","title":"The role of the carboxyl-terminal fragment of APP in the neurodegeneration and cognitive loss in Alzheimer disease.","label":"The role of the carboxyl-terminal fragme...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","status":"Simple Annotation","id":"urn:lsid:swan.org:researchstatement:cc9e4a2f-490f-4870-a649-265fcde91823"},{"lsid":"urn:lsid:swan.org:researchstatement:64486629-deb2-4175-83aa-c054dd300576","title":"DNA damage may reduce the expression of genes involved in learning, memory and neuronal survival, initiating brain aging, the major risk factor for Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2004-06-24","id":"urn:lsid:swan.org:researchstatement:64486629-deb2-4175-83aa-c054dd300576","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:64486629-deb2-4175-83aa-c054dd300576&referrerLinkLabel=hypothesislist","label":"Lu T et al.; DNA damage may reduce the expression of ...","HotTopics":["The molecular mechanisms of neuronal cell death are involved in the dysfunction and death of neurons in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Pan Ying","Kao Shyan-Yuan","Li Cheng","Kohane Isaac","Chan Jennifer","Yankner Bruce A"],"firstAuthor":"Lu Tao","taxonomy":["Metabolism"],"referenceYear":"2004"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:beb73abe-e850-4182-998e-a7a847447b41\" title=\"Protein: Apolipoprotein E [Homo sapiens]\">Apolipoprotein E<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:217e8ed5-5079-4e00-bf2a-beab8a5f7de4\" title=\"Protein: Apolipoprotein E [Mus musculus]\">Apolipoprotein E<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:8d1bb864-d9ad-4f6d-85b0-c48f64bdb6b4\" title=\"Gene: Apoe apolipoprotein E [Mus musculus]\">Apoe<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0ee9b2c6-2de7-4e7c-af10-ace503bf6fae&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0ee9b2c6-2de7-4e7c-af10-ace503bf6fae&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Human Apolipoprotein E4 alters the amyloid-β 40:42 ratio and promotes the formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein transgenic mouse.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0ee9b2c6-2de7-4e7c-af10-ace503bf6fae&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":1,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0ee9b2c6-2de7-4e7c-af10-ace503bf6fae&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:0ee9b2c6-2de7-4e7c-af10-ace503bf6fae","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0ee9b2c6-2de7-4e7c-af10-ace503bf6fae&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"supportedby":11,"containedwithoutevidence":5,"taxonomy":["ApoE"],"referenceYear":"2005","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0ee9b2c6-2de7-4e7c-af10-ace503bf6fae&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:0ee9b2c6-2de7-4e7c-af10-ace503bf6fae","containedwithevidence":28,"type":"Hypothesis","contained":33,"status":"Extended Annotation","referenceDate":"2005-03-16","containedevidencecount":52,"alternativeto":5,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0ee9b2c6-2de7-4e7c-af10-ace503bf6fae&referrerLinkLabel=hypothesislist","label":"Fryer J et al.; Human Apolipoprotein E4 alters the amylo...","otherAuthors":["Simmons Kelly","Parsadanian Maia","Bales Kelly R","Paul Steven M","Sullivan Patrick M","Holtzman David M"],"firstAuthor":"Fryer John D"},{"lsid":"urn:lsid:swan.org:researchstatement:48689183-ca6c-4459-bfa8-17aae929ac62","title":"The underlying mechanistic link between statin treatment and a reduced prevalence for Alzheimer disease may involve vascular or inflammatory pathways.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2007","id":"urn:lsid:swan.org:researchstatement:48689183-ca6c-4459-bfa8-17aae929ac62","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:48689183-ca6c-4459-bfa8-17aae929ac62&referrerLinkLabel=hypothesislist","label":"Höglund K et al.; The underlying mechanistic link between ...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Blennow Kaj"],"firstAuthor":"Höglund Kina","taxonomy":["Trophic Factors"],"referenceYear":"2007"},{"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:2b578ad0-af45-4d72-85a5-a373b6ee0b50&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:2b578ad0-af45-4d72-85a5-a373b6ee0b50","type":"Hypothesis","title":"Aluminosilicate precipitations and Alzheimer's disease.","label":"Meyer C; Aluminosilicate precipitations and Alzhe...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","status":"Simple Annotation","firstAuthor":"Meyer Colin","id":"urn:lsid:swan.org:researchstatement:2b578ad0-af45-4d72-85a5-a373b6ee0b50"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>; ","containedwithevidence":9,"lsid":"urn:lsid:swan.org:researchstatement:ad816b8b-92a7-4f89-af3f-109e067ea1dd","title":"[ADNI]  Increased cerebrospinal fluid (CSF) tau is a biomarker of AD pathology that correlates with clinical severity of Alzheimer Disease.","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ad816b8b-92a7-4f89-af3f-109e067ea1dd&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":9,"status":"Extended Annotation","id":"urn:lsid:swan.org:researchstatement:ad816b8b-92a7-4f89-af3f-109e067ea1dd","containedevidencecount":16,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ad816b8b-92a7-4f89-af3f-109e067ea1dd&referrerLinkLabel=hypothesislist","label":"Jack C et al.; [ADNI]  Increased cerebrospinal fluid (C...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Biomarkers are useful for predicting and staging Alzheimer disease"],"otherAuthors":["Knopman David S","Jagust William J","Shaw Leslie M","Aisen Paul S","Weiner M","Petersen Ronald C","Trojanowski John Q"],"containedwithoutevidence":0,"firstAuthor":"Jack Clifford R","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ad816b8b-92a7-4f89-af3f-109e067ea1dd&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsid":"urn:lsid:swan.org:researchstatement:cb71a62f-0fd8-46ad-8dec-f9b933f2983e","title":"Dendritic changes play a role in the malfunctioning of the brain and may be a forerunner to the neuronal loss.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1998-08","id":"urn:lsid:swan.org:researchstatement:cb71a62f-0fd8-46ad-8dec-f9b933f2983e","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:cb71a62f-0fd8-46ad-8dec-f9b933f2983e&referrerLinkLabel=hypothesislist","label":"Anderton B et al.; Dendritic changes play a role in the mal...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Callahan L","Coleman P","Flood D","Jicha G A","Ohm T","Weaver C"],"firstAuthor":"Anderton B H","referenceYear":"1998"},{"lsid":"urn:lsid:swan.org:researchstatement:515b5a05-e0b7-4722-aac6-b98715dff4a7","title":"ApoE exhibits isoform-specific neurotoxicity.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1996-11-04","id":"urn:lsid:swan.org:researchstatement:515b5a05-e0b7-4722-aac6-b98715dff4a7","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:515b5a05-e0b7-4722-aac6-b98715dff4a7&referrerLinkLabel=hypothesislist","label":"Marques M et al.; ApoE exhibits isoform-specific neurotoxi...","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Tolar M","Harmony J A","Crutcher K A"],"firstAuthor":"Marques M A","taxonomy":["ApoE"],"referenceYear":"1996"},{"lsid":"urn:lsid:swan.org:researchstatement:e327ae26-c10d-4a5a-b1d1-f48165861b7c","title":"The combination of HSV1 in brain and carriage of an APOE-epsilon 4 allele is a strong risk factor for Alzheimer disease, whereas either of these features alone does not increase the risk of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1997-01-25","id":"urn:lsid:swan.org:researchstatement:e327ae26-c10d-4a5a-b1d1-f48165861b7c","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e327ae26-c10d-4a5a-b1d1-f48165861b7c&referrerLinkLabel=hypothesislist","label":"Itzhaki R et al.; The combination of HSV1 in brain and car...","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Lin W R","Shang D","Wilcock G K","Faragher B","Jamieson G A"],"firstAuthor":"Itzhaki R F","taxonomy":["Oxidation"],"referenceYear":"1997"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>; ","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:46f21570-2957-4d65-89f6-d1c97f818be4&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Proteasomal system dysfunction causes neurodegeneration in Alzheimer disease.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:46f21570-2957-4d65-89f6-d1c97f818be4&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:46f21570-2957-4d65-89f6-d1c97f818be4&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:46f21570-2957-4d65-89f6-d1c97f818be4","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:46f21570-2957-4d65-89f6-d1c97f818be4&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Misfolded proteins accumulated into protein aggregates characterizes the pathologic lesions of Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":12,"containedwithoutevidence":12,"referenceYear":"2003","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:46f21570-2957-4d65-89f6-d1c97f818be4&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:46f21570-2957-4d65-89f6-d1c97f818be4","containedwithevidence":39,"type":"Hypothesis","contained":51,"status":"Extended Annotation","referenceDate":"2003-04","containedevidencecount":60,"alternativeto":4,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:46f21570-2957-4d65-89f6-d1c97f818be4&referrerLinkLabel=hypothesislist","label":"Keck S et al.; Proteasomal system dysfunction causes ne...","otherAuthors":["Nitsch Robert","Grune Tilman","Ullrich Oliver"],"firstAuthor":"Keck Susi"},{"lsid":"urn:lsid:swan.org:researchstatement:66e75ff2-fb84-46fc-9c81-f10f30a4a0c2","title":"APP Intracellular Domain (AICD) is a positive regulator of apoptosis, may add to the toxic effect of A&#946;42 aggregates and further accelerate neurodegeneration.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2000-11","id":"urn:lsid:swan.org:researchstatement:66e75ff2-fb84-46fc-9c81-f10f30a4a0c2","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:66e75ff2-fb84-46fc-9c81-f10f30a4a0c2&referrerLinkLabel=hypothesislist","label":"Passer B et al.; APP Intracellular Domain (AICD) is a pos...","HotTopics":["The molecular mechanisms of neuronal cell death are involved in the dysfunction and death of neurons in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Pellegrini L","Russo C","Siegel R M","Lenardo M J","Schettini G","Bachmann M","Tabaton M","D'Adamio L"],"firstAuthor":"Passer B","taxonomy":["Protein Processing"],"referenceYear":"2000"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:c1430899-49ef-463a-b3ef-d2f012c51f2c\" title=\"Protein: Transcription factor jun-B [Homo sapiens]\">Transcription factor jun-B<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:5d26d232-2641-4f61-b8da-bd9d52651192\" title=\"Protein: Transcription factor jun-D [Homo sapiens]\">Transcription factor jun-D<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:338f168b-c8e1-4dd9-9375-d6d1dad7ea48\" title=\"Gene: JUND jun D proto-oncogene [Homo sapiens]\">JUND<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:556ba7cb-1973-4043-80cc-01ceafd96735\" title=\"Gene: JUNB jun B proto-oncogene [Homo sapiens]\">JUNB<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f4beb3c2-b238-48bf-8b4a-37e1b68668c8\" title=\"Protein: Apoptosis regulator Bcl-2 [Homo sapiens]\">Apoptosis regulator Bcl-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:9304f156-af28-46f3-ab4b-3740dd55ccb8\" title=\"Protein: Transcription factor AP-1 [Homo sapiens]\">Transcription factor AP-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:82d4fbef-5aa7-4ba3-a73e-44d598ba7a44\" title=\"Protein: DNA-(apurinic or apyrimidinic site) lyase [Homo sapiens]\">DNA-(apurinic or apyrimidinic site) lyase<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:2d7a8efc-3ccb-445b-bd87-559027010977\" title=\"Protein: Apoptosis regulator BAX [Homo sapiens]\">Apoptosis regulator BAX<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f30ed489-13cd-4cc0-ae2b-b6ed8ebd61a2\" title=\"Protein: Apoptosis regulator Bcl-2 [Mus musculus]\">Apoptosis regulator Bcl-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:73eea679-7acd-4020-bb8a-fdacd381fdb4\" title=\"Gene: Bcl2 B-cell leukemia/lymphoma 2 [Mus musculus]\">Bcl2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:a4b71771-5809-4b91-98f1-73dc0dc0c74f\" title=\"Gene: Jun Jun oncogene [Mus musculus]\">Jun<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:eea2fa1a-bf96-4a0e-a781-87896f8a346c\" title=\"Gene: Psen1 presenilin 1 [Mus musculus]\">Psen1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:bb556fbc-2992-4a5c-aca1-9d5d452ed2f9\" title=\"Gene: Psen2 presenilin 2 [Mus musculus]\">Psen2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:c5e2ea97-9e43-4d40-8b0c-e18f9402ed75\" title=\"Protein: Transcription factor AP-1 [Mus musculus]\">Transcription factor AP-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e02dc3a7-d334-4ba4-9474-5dadce8ca9f6\" title=\"Protein: Microtubule-associated protein tau [Mus musculus]\">Microtubule-associated protein tau<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0cc36913-2d22-432d-b76a-6860a4bed641&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0cc36913-2d22-432d-b76a-6860a4bed641&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Apoptosis is a mechanism of neuronal death in Alzheimer disease.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0cc36913-2d22-432d-b76a-6860a4bed641&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":3,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0cc36913-2d22-432d-b76a-6860a4bed641&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:0cc36913-2d22-432d-b76a-6860a4bed641","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0cc36913-2d22-432d-b76a-6860a4bed641&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["The molecular mechanisms of neuronal cell death are involved in the dysfunction and death of neurons in Alzheimer Disease"],"supportedby":12,"containedwithoutevidence":46,"taxonomy":["Apoptosis"],"referenceYear":"1996","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0cc36913-2d22-432d-b76a-6860a4bed641&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:0cc36913-2d22-432d-b76a-6860a4bed641","containedwithevidence":69,"type":"Hypothesis","contained":115,"status":"Extended Annotation","referenceDate":"1996-10","containedevidencecount":118,"alternativeto":8,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0cc36913-2d22-432d-b76a-6860a4bed641&referrerLinkLabel=hypothesislist","label":"Cotman C et al.; Apoptosis is a mechanism of neuronal dea...","otherAuthors":["Su J H"],"firstAuthor":"Cotman C W"},{"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:14f868fa-b509-4214-9f65-fd7cec1213ff&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:14f868fa-b509-4214-9f65-fd7cec1213ff","type":"Hypothesis","title":"Calcium signaling deficit hypothesis for Alzheimer's disease.","label":"Chen M; Calcium signaling deficit hypothesis for...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","status":"Simple Annotation","firstAuthor":"Chen Ming","id":"urn:lsid:swan.org:researchstatement:14f868fa-b509-4214-9f65-fd7cec1213ff"},{"lsid":"urn:lsid:swan.org:researchstatement:4538395b-f97e-4324-89a9-0f0d6aab15ff","title":"ACAT inhibition reduces Aβ production.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2004-10-14","id":"urn:lsid:swan.org:researchstatement:4538395b-f97e-4324-89a9-0f0d6aab15ff","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4538395b-f97e-4324-89a9-0f0d6aab15ff&referrerLinkLabel=hypothesislist","label":"Hutter-Paier B et al.; ACAT inhibition reduces Aβ production.","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Huttunen Henri J","Puglielli Luigi","Eckman Christopher B","Kim Doo Yeon","Hofmeister Alexander","Moir Robert D","Domnitz Sarah B","Frosch Matthew P","Windisch Manfred","Kovacs Dora M"],"firstAuthor":"Hutter-Paier Birgit","taxonomy":["Trophic Factors"],"referenceYear":"2004"},{"lsid":"urn:lsid:swan.org:researchstatement:2becc0ad-63e1-4a59-b1bf-8497c4f928ad","title":"Aluminum is important in the pathogenesis of Alzheimer disease neurodegenerative process.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1986","id":"urn:lsid:swan.org:researchstatement:2becc0ad-63e1-4a59-b1bf-8497c4f928ad","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:2becc0ad-63e1-4a59-b1bf-8497c4f928ad&referrerLinkLabel=hypothesislist","label":"McLachlan D; Aluminum is important in the pathogenesi...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","firstAuthor":"McLachlan D R","taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"1986"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:afee309a-581e-4fe3-9bc9-6c078ee54dae\" title=\"Gene: Prnp prion protein [Mus musculus]\">Prnp<\/a>; ","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d1fc5e21-3233-4ba7-94c6-46675af55a6b&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d1fc5e21-3233-4ba7-94c6-46675af55a6b&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:d1fc5e21-3233-4ba7-94c6-46675af55a6b","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d1fc5e21-3233-4ba7-94c6-46675af55a6b&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Synaptic loss appears to be the most powerful and ubiquitous proximate factor leading to the dementia of Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":3,"containedwithoutevidence":1,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d1fc5e21-3233-4ba7-94c6-46675af55a6b&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:d1fc5e21-3233-4ba7-94c6-46675af55a6b","containedwithevidence":9,"type":"Hypothesis","contained":10,"status":"Extended Annotation","referenceDate":"2009-02-26","containedevidencecount":10,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d1fc5e21-3233-4ba7-94c6-46675af55a6b&referrerLinkLabel=hypothesislist","label":"Laurén J et al.; Cellular prion protein mediates impairme...","otherAuthors":["Gimbel David A","Nygaard Haakon B","Gilbert John W","Strittmatter Stephen M"],"firstAuthor":"Laurén Juha"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f55fb8c9-49d7-40de-9e7e-1e598a489e64\" title=\"Protein: Synaptophysin [Homo sapiens]\">Synaptophysin<\/a>; ","containedwithevidence":6,"lsid":"urn:lsid:swan.org:researchstatement:f7f7b437-f7b6-461d-a6b8-8e89c79494d0","title":"[ADNI]  Decreased fluorodeoxyglucose uptake on PET (FDG-PET) is a biomarker of reduced brain glucose metabolism and synaptic activity in AD.","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f7f7b437-f7b6-461d-a6b8-8e89c79494d0&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":6,"status":"Extended Annotation","id":"urn:lsid:swan.org:researchstatement:f7f7b437-f7b6-461d-a6b8-8e89c79494d0","containedevidencecount":14,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f7f7b437-f7b6-461d-a6b8-8e89c79494d0&referrerLinkLabel=hypothesislist","label":"Jack C et al.; [ADNI]  Decreased fluorodeoxyglucose upt...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Biomarkers are useful for predicting and staging Alzheimer disease"],"otherAuthors":["Knopman David S","Jagust William J","Shaw Leslie M","Aisen Paul S","Weiner M","Petersen Ronald C","Trojanowski John Q"],"containedwithoutevidence":0,"firstAuthor":"Jack Clifford R","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f7f7b437-f7b6-461d-a6b8-8e89c79494d0&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a9e26e44-08c6-45f3-9dfb-d386feab0b55\" title=\"Protein: Presenilin-2 [Homo sapiens]\">Presenilin-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:cfdaa5e5-f0e7-43f1-9347-558c2044dee8\" title=\"Gene: PSEN2 presenilin 2 (Alzheimer disease 4) [Homo sapiens]\">PSEN2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:13e0de11-9022-41f1-8578-24e3cddccdac\" title=\"Protein: Cadherin-2 [Homo sapiens]\">Cadherin-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:5bbeeb6a-380d-42d3-84f1-100949bd95d4\" title=\"Protein: Neurogenic locus notch homolog protein 1 [Homo sapiens]\">Neurogenic locus notch homolog protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:877a0d20-8709-4c2d-a1a8-fb1873be3124\" title=\"Protein: Catenin beta-1 [Homo sapiens]\">Catenin beta-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c8029a6-bdff-4298-a726-9d323d5cf326\" title=\"Protein: Gamma-secretase subunit PEN-2 [Homo sapiens]\">Gamma-secretase subunit PEN-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d1b70427-57d3-4d6d-951d-9fc185717d9c\" title=\"Protein: Alpha-synuclein [Homo sapiens]\">Alpha-synuclein<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=6239\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Caenorhabditis elegans<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:4811dbc6-b849-440b-b65d-f6f45d7ae980\" title=\"Gene: sel-12 Suppressor/Enhancer of Lin-12 [Caenorhabditis elegans]\">sel-12<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:f47e85b8-4973-4497-be20-cf5c5c405587\" title=\"Gene: lin-12 abnormal cell LINeage [Caenorhabditis elegans]\">lin-12<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=7227\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Drosophila melanogaster<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:35c14215-6c73-47a2-8bae-07fe0c301be0\" title=\"Gene: PS Presenilin [Drosophila melanogaster]\">PS<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:eea2fa1a-bf96-4a0e-a781-87896f8a346c\" title=\"Gene: Psen1 presenilin 1 [Mus musculus]\">Psen1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:cbeae234-406a-4b34-b269-711445f644ee\" title=\"Protein: Presenilin-1 [Mus musculus]\">Presenilin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b1d08c46-e135-4d0a-a349-bda2f2c7e44f\" title=\"Protein: Presenilin-2 [Mus musculus]\">Presenilin-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:16201340-db4d-4b71-93c0-c6b31e2184b8\" title=\"Protein: Microtubule-associated protein 2 [Mus musculus]\">Microtubule-associated protein 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:2ed39882-7c4d-407b-8b87-3c12fb464666\" title=\"Protein: Glial fibrillary acidic protein [Mus musculus]\">Glial fibrillary acidic protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:02f0b202-a771-4aa1-a2b6-65a793de50b0\" title=\"Protein: Tubulin beta-3 chain [Mus musculus]\">Tubulin beta-3 chain<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:992e5e07-471f-4b33-b211-354c992b974d\" title=\"Protein: Protein S100-B [Mus musculus]\">Protein S100-B<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:8ff22bfa-ebe5-4f9c-b8fa-12baf7e6b3a3\" title=\"Protein: Amyloid beta A4 protein [Mus musculus]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:83f2638b-4871-4ec6-b093-9a838f33b5e6\" title=\"Protein: Neurogenic locus notch homolog protein 1 [Mus musculus]\">Neurogenic locus notch homolog protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:30e56abe-c289-4ee3-9fd9-2352135f7b6d\" title=\"Protein: Transcription factor HES-1 [Mus musculus]\">Transcription factor HES-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:bb556fbc-2992-4a5c-aca1-9d5d452ed2f9\" title=\"Gene: Psen2 presenilin 2 [Mus musculus]\">Psen2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a9093118-bcef-4dd0-965d-bd38b3d55a01\" title=\"Protein: Recombining binding protein suppressor of hairless [Mus musculus]\">Recombining binding protein suppressor of hairless<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:34f806b8-58c5-4a7b-8f7f-66521550e62d&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Loss of essential functions of presenilin can explain dementia and neurodegeneration in Alzheimer disease.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:34f806b8-58c5-4a7b-8f7f-66521550e62d&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":11,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:34f806b8-58c5-4a7b-8f7f-66521550e62d&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:34f806b8-58c5-4a7b-8f7f-66521550e62d","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:34f806b8-58c5-4a7b-8f7f-66521550e62d&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Changes in presenilin function lead to dementia and neurodegeneration in Alzheimer Disease"],"supportedby":35,"containedwithoutevidence":0,"taxonomy":["Metabolism"],"referenceYear":"2007","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:34f806b8-58c5-4a7b-8f7f-66521550e62d&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:34f806b8-58c5-4a7b-8f7f-66521550e62d","containedwithevidence":67,"type":"Hypothesis","contained":67,"status":"Extended Annotation","referenceDate":"2007-01-09","containedevidencecount":119,"alternativeto":21,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:34f806b8-58c5-4a7b-8f7f-66521550e62d&referrerLinkLabel=hypothesislist","label":"Shen J et al.; Loss of essential functions of presenili...","otherAuthors":["Kelleher Raymond J"],"firstAuthor":"Shen Jie"},{"lsid":"urn:lsid:swan.org:researchstatement:7a1f7c5d-b42c-48b1-a6a3-c6bdbff1d1a1","title":"Reactivation of dormant HSV1 might be the cause of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1982-08","id":"urn:lsid:swan.org:researchstatement:7a1f7c5d-b42c-48b1-a6a3-c6bdbff1d1a1","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7a1f7c5d-b42c-48b1-a6a3-c6bdbff1d1a1&referrerLinkLabel=hypothesislist","label":"Ball M; Reactivation of dormant HSV1 might be th...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","firstAuthor":"Ball M J","taxonomy":["Oxidation"],"referenceYear":"1982"},{"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:92b81481-6571-46a8-982b-1f66b36676a4&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:92b81481-6571-46a8-982b-1f66b36676a4","type":"Hypothesis","title":"Towards an animal model of Alzheimer's disease. Can phorbol esters fan the flames?","label":"Smalheiser N; Towards an animal model of Alzheimer's d...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","status":"Simple Annotation","firstAuthor":"Smalheiser Neil R.","id":"urn:lsid:swan.org:researchstatement:92b81481-6571-46a8-982b-1f66b36676a4"},{"lsid":"urn:lsid:swan.org:researchstatement:b667b04c-41ca-46eb-a4db-9ff0310ad943","title":"The process of memory consolidation involves the synthesis of novel macromolecules recognized by the immune system as \"non-self\" antigens.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2006-11","id":"urn:lsid:swan.org:researchstatement:b667b04c-41ca-46eb-a4db-9ff0310ad943","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b667b04c-41ca-46eb-a4db-9ff0310ad943&referrerLinkLabel=hypothesislist","label":"Arshavsky Y; The process of memory consolidation invo...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","firstAuthor":"Arshavsky Y I","taxonomy":["Inflammation"],"referenceYear":"2006"},{"lsid":"urn:lsid:swan.org:researchstatement:10b889eb-10fd-411e-b0df-9ba16d555dad","title":"A downregulation of calcineurin may contribute to the dysregulation of glutamate release that is considered a hallmark of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2007-05","id":"urn:lsid:swan.org:researchstatement:10b889eb-10fd-411e-b0df-9ba16d555dad","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:10b889eb-10fd-411e-b0df-9ba16d555dad&referrerLinkLabel=hypothesislist","label":"Celsi F et al.; A downregulation of calcineurin may cont...","HotTopics":["Changes in calcium homeostasis may provide a common pathway for the neuropathological changes in AD"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Svedberg M","Unger C","Cotman C W","Carrì M T","Ottersen O P","Nordberg A","Torp R"],"firstAuthor":"Celsi F","taxonomy":["Metabolism"],"referenceYear":"2007"},{"lsid":"urn:lsid:swan.org:researchstatement:95667f38-7b05-4272-b214-2c3a6b1a0635","title":"Pathological changes in both L-type Ca2+ channels and RyRs accelerate functional decline during aging and Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2007-06","id":"urn:lsid:swan.org:researchstatement:95667f38-7b05-4272-b214-2c3a6b1a0635","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:95667f38-7b05-4272-b214-2c3a6b1a0635&referrerLinkLabel=hypothesislist","label":"Thibault O et al.; Pathological changes in both L-type Ca2+...","HotTopics":["Changes in calcium homeostasis may provide a common pathway for the neuropathological changes in AD"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Gant John C","Landfield Philip W"],"firstAuthor":"Thibault Olivier","taxonomy":["Trophic Factors"],"referenceYear":"2007"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:279cdb16-11c8-4638-bbff-1a3f9df9e6b4\" title=\"Gene: SIRT1 sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) [Homo sapiens]\">SIRT1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:1b4e1d74-45cd-40de-8d1d-228b333cc4de\" title=\"Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) [Homo sapiens]\">CDK5R1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:0c603f05-0fc8-4740-bf88-023b36359320\" title=\"Gene: SOD1 superoxide dismutase 1, soluble [Homo sapiens]\">SOD1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:447b9f10-4023-477e-a040-2c2e2c09680f\" title=\"Protein: NAD-dependent deacetylase sirtuin-1 [Homo sapiens]\">NAD-dependent deacetylase sirtuin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6fd6ee65-d26e-4259-840c-46ec22eab2d2\" title=\"Protein: Cyclin-dependent kinase 5 activator 1 [Homo sapiens]\">Cyclin-dependent kinase 5 activator 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:7fe75218-5dff-4c9a-b409-640814331f95\" title=\"Protein: Superoxide dismutase [Cu-Zn] [Homo sapiens]\">Superoxide dismutase [Cu-Zn]<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:86ff69c5-a721-455d-ae1f-aca14b7681e5\" title=\"Gene: SIRT4 sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) [Homo sapiens]\">SIRT4<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:702fe438-c9af-437a-855b-fb58f9b240b7\" title=\"Gene: SIRT7 sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) [Homo sapiens]\">SIRT7<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:c2d2c928-cd96-4bdb-84e8-5ea3eb4556d4\" title=\"Gene: SIRT3 sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) [Homo sapiens]\">SIRT3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:363cc026-abf2-407b-ada5-ff74c6c7bcf6\" title=\"Gene: SIRT5 sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) [Homo sapiens]\">SIRT5<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:6706b5c8-c8b9-46e2-b989-03f7c606105a\" title=\"Gene: SIRT6 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) [Homo sapiens]\">SIRT6<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:6a43e23c-fac1-4909-b7ff-fa551355edc6\" title=\"Gene: SIRT2 sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) [Homo sapiens]\">SIRT2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:dabfd74f-09fd-4481-9e18-65f6fdd2c9eb\" title=\"Gene: HTT huntingtin [Homo sapiens]\">HTT<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=4932\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Saccharomyces cerevisiae<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:a5948e58-d3c0-4257-b96f-e0baf8d57078\" title=\"Gene: SIR2  [Saccharomyces cerevisiae]\">SIR2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:5025e179-44f3-4ebd-aba2-1c4c5524c5b9\" title=\"Protein: NAD-dependent histone deacetylase SIR2 [Saccharomyces cerevisiae]\">NAD-dependent histone deacetylase SIR2<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e2a5b2c9-9848-490b-b23f-dff60a9e7a3c\" title=\"Gene: Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) [Mus musculus]\">Sirt1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:33133212-14dd-4791-95b9-cebd715272a8\" title=\"Protein: Synaptophysin [Mus musculus]\">Synaptophysin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:abfd3b9e-9ba5-4d22-8605-ae57fef92a5d\" title=\"Protein: NAD-dependent deacetylase sirtuin-1 [Mus musculus]\">NAD-dependent deacetylase sirtuin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d3450d47-9f94-4b5b-9c1e-82a1dd750b1d\" title=\"Protein: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha [Mus musculus]\">Peroxisome proliferator-activated receptor gamma coactivator 1-alpha<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:2ed39882-7c4d-407b-8b87-3c12fb464666\" title=\"Protein: Glial fibrillary acidic protein [Mus musculus]\">Glial fibrillary acidic protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:5a55a153-9f31-4b3d-8e7c-91f41654e605\" title=\"Protein: Caspase-3 [Mus musculus]\">Caspase-3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6f52b8e0-c3bb-42e4-8695-1de0af25d68d\" title=\"Protein: Apoptosis regulator BAX [Mus musculus]\">Apoptosis regulator BAX<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:96d4257f-76b1-49c3-82c6-77b727d234c8\" title=\"Protein: ATP-dependent DNA helicase 2 subunit 1 [Mus musculus]\">ATP-dependent DNA helicase 2 subunit 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:296a8d0e-0705-421e-ac8e-8ff60718812e\" title=\"Protein: Cellular tumor antigen p53 [Mus musculus]\">Cellular tumor antigen p53<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:afcd2d85-697d-4270-bcbc-5431e4de9a60\" title=\"Gene: Mir134 microRNA 134 [Mus musculus]\">Mir134<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:ea3e04be-2f2a-40bd-af87-7d4593dec81f\" title=\"Gene: Trp53 transformation related protein 53 [Mus musculus]\">Trp53<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:89407158-3eed-4c52-bd5d-a09378c61615\" title=\"Gene: Bdnf brain derived neurotrophic factor [Mus musculus]\">Bdnf<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:647dbcd1-f5f0-4bcd-af7c-7e9d7d6e7f9b\" title=\"Protein: Brain-derived neurotrophic factor [Mus musculus]\">Brain-derived neurotrophic factor<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:ad36ea14-a29b-4361-b128-d7dfdcba37d8\" title=\"Protein: Cyclic AMP-responsive element-binding protein 1 [Mus musculus]\">Cyclic AMP-responsive element-binding protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:568f4fff-ac56-4a8f-9fff-0765458eeabd\" title=\"Gene: Creb1 cAMP responsive element binding protein 1 [Mus musculus]\">Creb1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:7ae9ad9a-4d6b-4ff7-bf37-a6cf636a3c1b\" title=\"Protein: Forkhead box protein O4 [Mus musculus]\">Forkhead box protein O4<\/a>; ","relatedToOthers":"true","title":"SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer\u2019s disease and amyotrophic lateral sclerosis.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:286d4645-67ca-40c5-a5db-1fa18cd10414&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:286d4645-67ca-40c5-a5db-1fa18cd10414&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:286d4645-67ca-40c5-a5db-1fa18cd10414","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:286d4645-67ca-40c5-a5db-1fa18cd10414&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Signaling mechanisms play a critical role in Alzheimer Disease"],"supportedby":2,"containedwithoutevidence":0,"taxonomy":["Functional Changes of Proteins"],"referenceYear":"2007","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:286d4645-67ca-40c5-a5db-1fa18cd10414&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:286d4645-67ca-40c5-a5db-1fa18cd10414","containedwithevidence":46,"type":"Hypothesis","contained":46,"status":"Extended Annotation","referenceDate":"2007-07-11","containedevidencecount":105,"alternativeto":3,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:286d4645-67ca-40c5-a5db-1fa18cd10414&referrerLinkLabel=hypothesislist","label":"Kim D et al.; SIRT1 deacetylase protects against neuro...","otherAuthors":["Nguyen Minh Dang","Dobbin Matthew M","Fischer Andre","Sananbenesi Farahnaz","Rodgers Joseph T","Delalle Ivana","Baur Joseph A","Sui Guangchao","Armour Sean M","Puigserver Pere","Sinclair David A","Tsai Li-Huei"],"firstAuthor":"Kim Dohoon"},{"lsid":"urn:lsid:swan.org:researchstatement:1ac7dfd2-c95c-4eb7-9d16-987f067204eb","title":"Toxic C100 Hypothesis: Abnormal carboxyl-terminal subfragments of &#946; APP in vivo may cause amyloidogenesis and specific neuropathology.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1992-11-15","id":"urn:lsid:swan.org:researchstatement:1ac7dfd2-c95c-4eb7-9d16-987f067204eb","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1ac7dfd2-c95c-4eb7-9d16-987f067204eb&referrerLinkLabel=hypothesislist","label":"Kammesheidt A et al.; Toxic C100 Hypothesis: Abnormal carboxyl...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Boyce F M","Spanoyannis A F","Cummings B J","Ortegón M","Cotman C","Vaught J L","Neve R L"],"firstAuthor":"Kammesheidt A","taxonomy":["Protein Processing"],"referenceYear":"1992"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:ba8464eb-7eb7-468f-91e1-ef84f183e907\" title=\"Gene: TNFRSF21 tumor necrosis factor receptor superfamily, member 21 [Homo sapiens]\">TNFRSF21<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:7b2da872-7ed3-4ddb-9ae8-98780562d8f3\" title=\"Gene: App amyloid beta (A4) precursor protein [Mus musculus]\">App<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:ba517d49-a843-44eb-8936-364427907175\" title=\"Gene: Aplp2 amyloid beta (A4) precursor-like protein 2 [Mus musculus]\">Aplp2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:f1365dcf-ee26-44bc-8741-89a57c805a6e\" title=\"Gene: Tnfrsf21 tumor necrosis factor receptor superfamily, member 21 [Mus musculus]\">Tnfrsf21<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:d789554a-ffd2-4af5-a899-de2a05defcee\" title=\"Gene: Bace1 beta-site APP cleaving enzyme 1 [Mus musculus]\">Bace1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:536d188c-c787-4718-a4d1-59107a3545ad\" title=\"Protein: Tumor necrosis factor receptor superfamily member 21 [Mus musculus]\">Tumor necrosis factor receptor superfamily member 21<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:73eea679-7acd-4020-bb8a-fdacd381fdb4\" title=\"Gene: Bcl2 B-cell leukemia/lymphoma 2 [Mus musculus]\">Bcl2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:87902131-fb05-4841-862d-961ba1b67d92\" title=\"Gene: Bax BCL2-associated X protein [Mus musculus]\">Bax<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:80a5d2bd-f45f-4564-878d-5da61417cb56\" title=\"Gene: Casp6 caspase 6 [Mus musculus]\">Casp6<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:fd2a46a2-48bd-4600-ba8c-d5296fc6c9e5\" title=\"Gene: Casp3 caspase 3 [Mus musculus]\">Casp3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a4f60d26-bf73-48d7-b524-8b9024c3ceba\" title=\"Protein: Tumor necrosis factor receptor superfamily member 16 [Mus musculus]\">Tumor necrosis factor receptor superfamily member 16<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e02dc3a7-d334-4ba4-9474-5dadce8ca9f6\" title=\"Protein: Microtubule-associated protein tau [Mus musculus]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:d021a348-cb75-492a-8869-0799ba463299\" title=\"Gene: Ngf nerve growth factor [Mus musculus]\">Ngf<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:8b7d1332-65f1-48e4-aac2-7c5193ed98e6\" title=\"Gene: Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a [Mus musculus]\">Tnfrsf1a<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:d94dd1ca-5f01-4a1a-a2f4-9fb1cb8f47d8\" title=\"Gene: Ngfr nerve growth factor receptor (TNFR superfamily, member 16) [Mus musculus]\">Ngfr<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:2f31c897-0d77-4b40-93fc-2626c8e661cf\" title=\"Gene: Tnf tumor necrosis factor [Mus musculus]\">Tnf<\/a>; ","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:333479d7-fb0d-46aa-b0a6-e837e232c2c8&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:333479d7-fb0d-46aa-b0a6-e837e232c2c8&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:333479d7-fb0d-46aa-b0a6-e837e232c2c8","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:333479d7-fb0d-46aa-b0a6-e837e232c2c8&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["The molecular mechanisms of neuronal cell death are involved in the dysfunction and death of neurons in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":1,"containedwithoutevidence":2,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:333479d7-fb0d-46aa-b0a6-e837e232c2c8&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:333479d7-fb0d-46aa-b0a6-e837e232c2c8","containedwithevidence":20,"type":"Hypothesis","contained":22,"status":"Extended Annotation","referenceDate":"2009-02-19","containedevidencecount":51,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:333479d7-fb0d-46aa-b0a6-e837e232c2c8&referrerLinkLabel=hypothesislist","label":"Nikolaev A et al.; APP binds DR6 to trigger axon pruning an...","otherAuthors":["McLaughlin Todd","O'Leary Dennis D","Tessier-Lavigne Marc"],"firstAuthor":"Nikolaev Anatoly"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:beb73abe-e850-4182-998e-a7a847447b41\" title=\"Protein: Apolipoprotein E [Homo sapiens]\">Apolipoprotein E<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:cfdaa5e5-f0e7-43f1-9347-558c2044dee8\" title=\"Gene: PSEN2 presenilin 2 (Alzheimer disease 4) [Homo sapiens]\">PSEN2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a9e26e44-08c6-45f3-9dfb-d386feab0b55\" title=\"Protein: Presenilin-2 [Homo sapiens]\">Presenilin-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:293c1903-e8cd-456d-a8aa-57398e50a845&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:293c1903-e8cd-456d-a8aa-57398e50a845&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"The Amyloid Hypothesis of Alzheimer Disease.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:293c1903-e8cd-456d-a8aa-57398e50a845&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":6,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:293c1903-e8cd-456d-a8aa-57398e50a845&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:293c1903-e8cd-456d-a8aa-57398e50a845","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:293c1903-e8cd-456d-a8aa-57398e50a845&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Aβ accumulation in the brain is the primary event in Alzheimer Disease pathogenesis"],"supportedby":26,"containedwithoutevidence":1,"taxonomy":["Amyloid"],"referenceYear":"2002","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:293c1903-e8cd-456d-a8aa-57398e50a845&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:293c1903-e8cd-456d-a8aa-57398e50a845","containedwithevidence":54,"type":"Hypothesis","contained":55,"status":"Extended Annotation","referenceDate":"2002-07-19","containedevidencecount":106,"alternativeto":19,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:293c1903-e8cd-456d-a8aa-57398e50a845&referrerLinkLabel=hypothesislist","label":"Hardy J et al.; The Amyloid Hypothesis of Alzheimer Dise...","otherAuthors":["Selkoe Dennis J"],"firstAuthor":"Hardy John"},{"lsid":"urn:lsid:swan.org:researchstatement:f69338d5-f92e-4d90-b246-5a7d9ee9a77c","title":"Polymorphisms in inflammatory genes enhance the risk of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2001-11","id":"urn:lsid:swan.org:researchstatement:f69338d5-f92e-4d90-b246-5a7d9ee9a77c","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f69338d5-f92e-4d90-b246-5a7d9ee9a77c&referrerLinkLabel=hypothesislist","label":"McGeer P et al.; Polymorphisms in inflammatory genes enha...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["McGeer E G"],"firstAuthor":"McGeer P L","referenceYear":"2001"},{"lsid":"urn:lsid:swan.org:researchstatement:b72e53e1-6944-4e15-a3ed-66ecafd48831","title":"Inert amyloid plaques are potentially major sources of neurotoxic soluble protofibrillar Abeta-aggregates by exposure to biological lipids.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2008-01-09","id":"urn:lsid:swan.org:researchstatement:b72e53e1-6944-4e15-a3ed-66ecafd48831","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b72e53e1-6944-4e15-a3ed-66ecafd48831&referrerLinkLabel=hypothesislist","label":"Martins I et al.; Inert amyloid plaques are potentially ma...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Kuperstein Inna","Wilkinson Hannah","Maes Elke","Vanbrabant Mieke","Jonckheere Wim","Van Gelder Patrick","Hartmann Dieter","D'Hooge Rudi","De Strooper Bart","Schymkowitz Joost","Rousseau Frederic"],"firstAuthor":"Martins Ivo Cristiano","referenceYear":"2008"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:49ffd23c-235c-4ebe-b571-fa09f1414cb2\" title=\"Protein: Beta-secretase 1 [Homo sapiens]\">Beta-secretase 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:beb73abe-e850-4182-998e-a7a847447b41\" title=\"Protein: Apolipoprotein E [Homo sapiens]\">Apolipoprotein E<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:0df141f8-0c53-43b8-a257-ebea6452f981\" title=\"Gene: BACE1 beta-site APP-cleaving enzyme 1 [Homo sapiens]\">BACE1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:cfdaa5e5-f0e7-43f1-9347-558c2044dee8\" title=\"Gene: PSEN2 presenilin 2 (Alzheimer disease 4) [Homo sapiens]\">PSEN2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:9d11160e-94ad-4760-92a9-591e1d221769&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:9d11160e-94ad-4760-92a9-591e1d221769&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"The Aβ hypothesis will lead to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:9d11160e-94ad-4760-92a9-591e1d221769&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":4,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:9d11160e-94ad-4760-92a9-591e1d221769&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:9d11160e-94ad-4760-92a9-591e1d221769","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:9d11160e-94ad-4760-92a9-591e1d221769&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Aβ accumulation in the brain is the primary event in Alzheimer Disease pathogenesis"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":16,"containedwithoutevidence":19,"referenceYear":"2005","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:9d11160e-94ad-4760-92a9-591e1d221769&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:9d11160e-94ad-4760-92a9-591e1d221769","containedwithevidence":26,"type":"Hypothesis","contained":45,"status":"Extended Annotation","referenceDate":"2005-01","containedevidencecount":44,"alternativeto":4,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:9d11160e-94ad-4760-92a9-591e1d221769&referrerLinkLabel=hypothesislist","label":"Golde T; The Aβ hypothesis will lead to rationall...","firstAuthor":"Golde T"},{"lsid":"urn:lsid:swan.org:researchstatement:0315736e-f6a7-4095-8ee3-8cb8fda1744f","title":"Presenilin is a component of synaptic junctions.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2000","id":"urn:lsid:swan.org:researchstatement:0315736e-f6a7-4095-8ee3-8cb8fda1744f","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:0315736e-f6a7-4095-8ee3-8cb8fda1744f&referrerLinkLabel=hypothesislist","label":"Georgakopoulos A et al.; Presenilin is a component of synaptic ju...","HotTopics":["Synaptic loss appears to be the most powerful and ubiquitous proximate factor leading to the dementia of Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Marambaud P","Friedrich V L","Shioi J","Efthimiopoulos S","Robakis N K"],"firstAuthor":"Georgakopoulos A","taxonomy":["Synapses"],"referenceYear":"2000"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:49ffd23c-235c-4ebe-b571-fa09f1414cb2\" title=\"Protein: Beta-secretase 1 [Homo sapiens]\">Beta-secretase 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:37ed2516-311f-43cb-bdb9-6f8237fd8b59\" title=\"Protein: Oxysterols receptor LXR-alpha [Homo sapiens]\">Oxysterols receptor LXR-alpha<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:a737f4d7-a4fb-40ad-88ae-a2e422b6e71f\" title=\"Gene: CCL4 chemokine (C-C motif) ligand 4 [Homo sapiens]\">CCL4<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=4932\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Saccharomyces cerevisiae<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:1a23b12f-4dd8-4212-83c6-e5d1c95b5ad9\" title=\"Gene: YHL003C  [Saccharomyces cerevisiae]\">YHL003C<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f8d57c13-c3d1-4b1c-b2e7-7faafbf7b42f\" title=\"Protein: Sphingomyelin phosphodiesterase 3 [Mus musculus]\">Sphingomyelin phosphodiesterase 3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:c4afbb14-4e09-4e75-bcaf-2c2652a5f8e7\" title=\"Protein: Beta-nerve growth factor [Mus musculus]\">Beta-nerve growth factor<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:6e0efdea-1a18-44da-b8a4-719875007f49\" title=\"Gene: Smpd3 sphingomyelin phosphodiesterase 3, neutral [Mus musculus]\">Smpd3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f6435734-033e-4e39-8580-06a845215e77\" title=\"Protein: Sterol regulatory element-binding protein 1 [Mus musculus]\">Sterol regulatory element-binding protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b42d7c9d-0624-467c-9b8e-9320e625a1ff\" title=\"Protein: Sterol regulatory element-binding protein 2 [Mus musculus]\">Sterol regulatory element-binding protein 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a4f60d26-bf73-48d7-b524-8b9024c3ceba\" title=\"Protein: Tumor necrosis factor receptor superfamily member 16 [Mus musculus]\">Tumor necrosis factor receptor superfamily member 16<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9986\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Oryctolagus cuniculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:9946cd20-4394-4071-bea4-3516d80b7704\" title=\"Gene: ACAT acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) [Oryctolagus cuniculus]\">ACAT<\/a>; ","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:43a96c58-1757-446a-a083-bcc399305eb1&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Cholesterol and ceramide are molecular connections between normal aging of the brain and Alzheimer's Disease.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:43a96c58-1757-446a-a083-bcc399305eb1&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:43a96c58-1757-446a-a083-bcc399305eb1&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:43a96c58-1757-446a-a083-bcc399305eb1","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:43a96c58-1757-446a-a083-bcc399305eb1&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Cell membrane properties play a key role in AD Pathophysiology","Signaling mechanisms play a critical role in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":7,"containedwithoutevidence":27,"lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:43a96c58-1757-446a-a083-bcc399305eb1&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:43a96c58-1757-446a-a083-bcc399305eb1","containedwithevidence":39,"type":"Hypothesis","contained":66,"status":"Extended Annotation","containedevidencecount":68,"alternativeto":8,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:43a96c58-1757-446a-a083-bcc399305eb1&referrerLinkLabel=hypothesislist","label":"Costantini C et al.; Cholesterol and ceramide are molecular c...","otherAuthors":["Kolasani Rekha M.K.","Puglielli Luigi"],"firstAuthor":"Costantini Claudio"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:beb73abe-e850-4182-998e-a7a847447b41\" title=\"Protein: Apolipoprotein E [Homo sapiens]\">Apolipoprotein E<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:dc39c47e-1e5c-4253-a762-9f9e558919fe\" title=\"Protein: Clusterin [Homo sapiens]\">Clusterin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:c97485d8-7ae3-4313-8d36-6246cd9318ff\" title=\"Gene: CR1 complement component (3b/4b) receptor 1 (Knops blood group) [Homo sapiens]\">CR1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:d4e70f4a-d0fd-4c63-ac0e-16b07d929b28\" title=\"Gene: CLU clusterin [Homo sapiens]\">CLU<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:0773312d-5370-49ae-975d-d7be24b9b0f3\" title=\"Protein: Complement C3b alpha' chain [Homo sapiens]\">Complement C3b alpha' chain<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3e943a3c-3fe5-42f3-9612-206fc5c5d15e\" title=\"Protein: Complement C3 [Homo sapiens]\">Complement C3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:1f3b33d4-ba73-47a6-a19f-d9e61c2c688d\" title=\"Protein: Complement receptor type 1 [Homo sapiens]\">Complement receptor type 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:2c7cd8c8-f834-4e64-b9bd-6f1c653517c2\" title=\"Gene: PCDH11X protocadherin 11 X-linked [Homo sapiens]\">PCDH11X<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:95fd1cff-b1a2-4d0d-9e71-317e9fd8f1de\" title=\"Gene: PICALM phosphatidylinositol binding clathrin assembly protein [Homo sapiens]\">PICALM<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:32f74f23-d60f-4b57-8d05-c46727616384\" title=\"Gene: Cr1l complement component (3b/4b) receptor 1-like [Mus musculus]\">Cr1l<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:2b85a486-a158-4ecf-9e91-495548bbf226\" title=\"Gene: Cr2 complement receptor 2 [Mus musculus]\">Cr2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:18dee826-85dc-4055-a7bc-2f02bf148ef8\" title=\"Protein: Complement C4-B [Mus musculus]\">Complement C4-B<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:0e8c416d-04af-412f-a1ff-c50301347705\" title=\"Protein: Complement C1q subcomponent subunit A [Mus musculus]\">Complement C1q subcomponent subunit A<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:814d0394-babc-4c75-88bf-0ec3cffbd95c\" title=\"Gene: C1qa complement component 1, q subcomponent, alpha polypeptide [Mus musculus]\">C1qa<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:ba111c18-88ad-4ffe-b83f-832014d413d5\" title=\"Protein: Complement C3 [Mus musculus]\">Complement C3<\/a>; ","relatedToOthers":"true","title":"Clusterin (ApoJ) and Complement component receptor CR1 genes are associated with Late Onset AD.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:98925454-4384-428d-979c-3f85f5ba4acd&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:98925454-4384-428d-979c-3f85f5ba4acd&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:98925454-4384-428d-979c-3f85f5ba4acd","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:98925454-4384-428d-979c-3f85f5ba4acd&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Genetic variants modulate risk of AD"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":2,"containedwithoutevidence":0,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:98925454-4384-428d-979c-3f85f5ba4acd&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:98925454-4384-428d-979c-3f85f5ba4acd","containedwithevidence":22,"type":"Hypothesis","contained":22,"status":"Extended Annotation","referenceDate":"2009-10","containedevidencecount":43,"alternativeto":1,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:98925454-4384-428d-979c-3f85f5ba4acd&referrerLinkLabel=hypothesislist","label":"Lambert J et al.; Clusterin (ApoJ) and Complement componen...","otherAuthors":["Heath Simon","Even Gael","Campion Dominique","Sleegers Kristel","Hiltunen Mikko","Combarros Onofre","Zelenika Diana","Bullido Maria J","Tavernier Béatrice","Letenneur Luc","Bettens Karolien","Berr Claudine","Pasquier Florence","Fiévet Nathalie","Barberger-Gateau Pascale","Engelborghs Sebastiaan","De Deyn Peter","Mateo Ignacio","Franck Ana","Helisalmi Seppo","Porcellini Elisa","Hanon Olivier","de Pancorbo Marian M","Lendon Corinne","Dufouil Carole","Jaillard Céline","Leveillard Thierry","Alvarez Victoria","Bosco Paolo","Mancuso Michelangelo","Panza Francesco","Nacmias Benedetta","Bossù Paola","Piccardi Paola","Annoni Giorgio","Seripa Davide","Galimberti Daniela","Hannequin Didier","Licastro Federico","Soininen Hilkka","Ritchie Karen","Blanché Hélène","Dartigues Jean-François","Tzourio Christophe","Gut Ivo","Van Broeckhoven Christine","Alpérovitch Annick","Lathrop Mark","Amouyel Philippe"],"firstAuthor":"Lambert Jean-Charles"},{"lsid":"urn:lsid:swan.org:researchstatement:a4ec7e18-86ae-45a6-a264-a7ed84b7417e","title":"APP causes abnormal transport of NGF and cholinergic neurodegeneration.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2006-07-06","id":"urn:lsid:swan.org:researchstatement:a4ec7e18-86ae-45a6-a264-a7ed84b7417e","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a4ec7e18-86ae-45a6-a264-a7ed84b7417e&referrerLinkLabel=hypothesislist","label":"Salehi A et al.; APP causes abnormal transport of NGF and...","HotTopics":["Failure of axonal transport might be the underlying basis for neurodegeneration in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Delcroix Jean-Dominique","Belichenko Pavel V","Zhan Ke","Wu Chengbiao","Valletta Janice S","Takimoto-Kimura Ryoko","Kleschevnikov Alexander M","Sambamurti Kumar","Chung Peter P","Xia Weiming","Villar Angela","Campbell William A","Kulnane Laura Shapiro","Nixon Ralph A","Lamb Bruce T","Epstein Charles J","Stokin Gorazd B","Goldstein Lawrence S","Mobley William C"],"firstAuthor":"Salehi Ahmad","taxonomy":["Trophic Factors"],"referenceYear":"2006"},{"lsid":"urn:lsid:swan.org:researchstatement:1a0897ac-71f0-4ded-81eb-c8d0591714d3","title":"The ER is important as a regulatory site involved in the pathogenesis of neuronal degeneration in Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1997-11-15","id":"urn:lsid:swan.org:researchstatement:1a0897ac-71f0-4ded-81eb-c8d0591714d3","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1a0897ac-71f0-4ded-81eb-c8d0591714d3&referrerLinkLabel=hypothesislist","label":"Mattson M et al.; The ER is important as a regulatory site...","HotTopics":["Misfolded proteins accumulated into protein aggregates characterizes the pathologic lesions of Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Guo Q"],"firstAuthor":"Mattson M P","taxonomy":["Oxidation"],"referenceYear":"1997"},{"lsid":"urn:lsid:swan.org:researchstatement:804308c0-7812-4d8e-94b9-0db360b328a6","title":"Inflammatory Hypothesis: immune-mediated autodestructive processes occur in Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1992-02","id":"urn:lsid:swan.org:researchstatement:804308c0-7812-4d8e-94b9-0db360b328a6","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:804308c0-7812-4d8e-94b9-0db360b328a6&referrerLinkLabel=hypothesislist","label":"McGeer P et al.; Inflammatory Hypothesis: immune-mediated...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Rogers J"],"firstAuthor":"McGeer P L","taxonomy":["Inflammation"],"referenceYear":"1992"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a23bf644-cbd8-474d-a852-39e0872fdc3d\" title=\"Protein: Calsenilin [Homo sapiens]\">Calsenilin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:2f555223-d796-4203-8681-e46870d30a16\" title=\"Protein: Potassium voltage-gated channel subfamily D member 1 [Homo sapiens]\">Potassium voltage-gated channel subfamily D member 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:bd978a6b-c226-4474-976e-dc2d18be2ab1\" title=\"Protein: Potassium voltage-gated channel subfamily D member 3 [Homo sapiens]\">Potassium voltage-gated channel subfamily D member 3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:55679b5a-0a5c-407a-9c9a-0927e14f35a1\" title=\"Gene: KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3 [Homo sapiens]\">KCND3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Rattus norvegicus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:eccd6557-12ee-4d00-906f-8a7996107aa1\" title=\"Protein: Potassium voltage-gated channel subfamily D member 2 [Rattus norvegicus]\">Potassium voltage-gated channel subfamily D member 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:ae16c06d-afe3-4e91-82b2-838ea83e98ba\" title=\"Gene: Kcnd2 potassium voltage gated channel, Shal-related family, member 2 [Rattus norvegicus]\">Kcnd2<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e2900472-61db-45f0-adc8-98fd2a53c324\" title=\"Protein: Potassium voltage-gated channel subfamily D member 2 [Mus musculus]\">Potassium voltage-gated channel subfamily D member 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:31f02cb1-3ea3-44b6-94e6-135435446653\" title=\"Gene: Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 [Mus musculus]\">Kcnd2<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:90ea03d2-bc78-4fa6-b7ca-df7aab9d2be4&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Amyloid beta peptide is a physiological modulator of neuronal 'A'-type K+ current.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:90ea03d2-bc78-4fa6-b7ca-df7aab9d2be4&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":1,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:90ea03d2-bc78-4fa6-b7ca-df7aab9d2be4&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:90ea03d2-bc78-4fa6-b7ca-df7aab9d2be4","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:90ea03d2-bc78-4fa6-b7ca-df7aab9d2be4&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Cell membrane properties play a key role in AD Pathophysiology"],"supportedby":5,"containedwithoutevidence":0,"taxonomy":["Protein Aggregation and Deposition","Synapses"],"referenceYear":"2006","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:90ea03d2-bc78-4fa6-b7ca-df7aab9d2be4&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:90ea03d2-bc78-4fa6-b7ca-df7aab9d2be4","containedwithevidence":47,"type":"Hypothesis","contained":47,"status":"Extended Annotation","referenceDate":"2006-11","containedevidencecount":79,"alternativeto":1,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:90ea03d2-bc78-4fa6-b7ca-df7aab9d2be4&referrerLinkLabel=hypothesislist","label":"Plant L et al.; Amyloid beta peptide is a physiological ...","otherAuthors":["Webster Nicola J","Boyle John P","Ramsden Martin","Freir Darragh B","Peers Chris","Pearson Hugh A"],"firstAuthor":"Plant Leigh D"},{"lsid":"urn:lsid:swan.org:researchstatement:b1f0c433-dd2c-4f0c-8fb4-56a3406cd2fb","title":"Aβ clearance and catabolism contributes to risk of late-onset Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2002-07-19","id":"urn:lsid:swan.org:researchstatement:b1f0c433-dd2c-4f0c-8fb4-56a3406cd2fb","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b1f0c433-dd2c-4f0c-8fb4-56a3406cd2fb&referrerLinkLabel=hypothesislist","label":"Hardy J et al.; Aβ clearance and catabolism contributes ...","HotTopics":["Defective mechanisms of Aβ clearance contribute to Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Selkoe Dennis J"],"firstAuthor":"Hardy John","taxonomy":["Protein Degradation"],"referenceYear":"2002"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:031a230d-7cb3-45c0-94f7-a7b608724b4d\" title=\"Protein: Nicastrin [Homo sapiens]\">Nicastrin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:45dccdee-f207-4e31-9cd2-83bf74aada5e\" title=\"Protein: Gamma-secretase subunit APH-1A [Homo sapiens]\">Gamma-secretase subunit APH-1A<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a9e26e44-08c6-45f3-9dfb-d386feab0b55\" title=\"Protein: Presenilin-2 [Homo sapiens]\">Presenilin-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:13e0de11-9022-41f1-8578-24e3cddccdac\" title=\"Protein: Cadherin-2 [Homo sapiens]\">Cadherin-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c8029a6-bdff-4298-a726-9d323d5cf326\" title=\"Protein: Gamma-secretase subunit PEN-2 [Homo sapiens]\">Gamma-secretase subunit PEN-2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:5bbeeb6a-380d-42d3-84f1-100949bd95d4\" title=\"Protein: Neurogenic locus notch homolog protein 1 [Homo sapiens]\">Neurogenic locus notch homolog protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b3d25d4d-ae3f-4825-89e1-7d207f7a522c\" title=\"Protein: Gamma-secretase subunit APH-1B [Homo sapiens]\">Gamma-secretase subunit APH-1B<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:6c62fc4a-b8a2-435c-b0ab-b16a10239342\" title=\"Gene: APH1A anterior pharynx defective 1 homolog A (C. elegans) [Homo sapiens]\">APH1A<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:d673c765-909f-4267-a145-c4d3d555b758\" title=\"Gene: APH1B anterior pharynx defective 1 homolog B (C. elegans) [Homo sapiens]\">APH1B<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:cfdaa5e5-f0e7-43f1-9347-558c2044dee8\" title=\"Gene: PSEN2 presenilin 2 (Alzheimer disease 4) [Homo sapiens]\">PSEN2<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:7ec8ccdf-c7db-4a3b-a305-08a29611182e\" title=\"Protein: Gamma-secretase subunit APH-1B [Mus musculus]\">Gamma-secretase subunit APH-1B<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:0fe6d22d-8917-4f1c-8a47-96bd6c65dad0\" title=\"Protein: Putative gamma-secretase subunit APH-1C [Mus musculus]\">Putative gamma-secretase subunit APH-1C<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:d789554a-ffd2-4af5-a899-de2a05defcee\" title=\"Gene: Bace1 beta-site APP cleaving enzyme 1 [Mus musculus]\">Bace1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:69d2a0ef-f4e4-4d2c-83d6-a07337ebe386\" title=\"Gene: Aph1b anterior pharynx defective 1b homolog (C. elegans) [Mus musculus]\">Aph1b<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:47673dc4-4876-428b-bf02-0ea6ef181642\" title=\"Gene: Aph1c anterior pharynx defective 1c homolog (C. elegans) [Mus musculus]\">Aph1c<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:83f2638b-4871-4ec6-b093-9a838f33b5e6\" title=\"Protein: Neurogenic locus notch homolog protein 1 [Mus musculus]\">Neurogenic locus notch homolog protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:3889dcc7-469c-49cf-9fca-b8782f4e4e3e\" title=\"Gene: Ncstn nicastrin [Mus musculus]\">Ncstn<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:3e49e206-f1a4-4f14-b211-599f8a789337\" title=\"Gene: Hes5 hairy and enhancer of split 5 (Drosophila) [Mus musculus]\">Hes5<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:5592ccbf-6dc8-402a-b507-6c01fe17caf7\" title=\"Gene: Notch1 Notch gene homolog 1 (Drosophila) [Mus musculus]\">Notch1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:0237aeda-d66c-4821-abb4-35dee93d0d81\" title=\"Gene: Hes1 hairy and enhancer of split 1 (Drosophila) [Mus musculus]\">Hes1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:47979051-5a6e-4438-87af-7341c1a30b79\" title=\"Gene: Acsl1 acyl-CoA synthetase long-chain family member 1 [Mus musculus]\">Acsl1<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:facac65c-2fc8-46f2-86a5-b5f4abb8c216&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Aph1B  complex contributes to total γ-secretase activity in the human brain.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:facac65c-2fc8-46f2-86a5-b5f4abb8c216&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":2,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:facac65c-2fc8-46f2-86a5-b5f4abb8c216&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:facac65c-2fc8-46f2-86a5-b5f4abb8c216","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:facac65c-2fc8-46f2-86a5-b5f4abb8c216&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Changes in presenilin function lead to dementia and neurodegeneration in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":5,"containedwithoutevidence":0,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:facac65c-2fc8-46f2-86a5-b5f4abb8c216&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:facac65c-2fc8-46f2-86a5-b5f4abb8c216","containedwithevidence":11,"type":"Hypothesis","contained":11,"status":"Extended Annotation","referenceDate":"2009-05-01","containedevidencecount":23,"alternativeto":3,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:facac65c-2fc8-46f2-86a5-b5f4abb8c216&referrerLinkLabel=hypothesislist","label":"Serneels L et al.; Aph1B  complex contributes to total γ-se...","otherAuthors":["Van Biervliet Jérôme","Craessaerts Katleen","Dejaegere Tim","Horré Katrien","Van Houtvin Tine","Esselmann Hermann","Paul Sabine","Schäfer Martin K","Berezovska Oksana","Hyman Bradley T","Sprangers Ben","Sciot Raf","Moons Lieve","Jucker Mathias","Yang Zhixiang","May Patrick C","Karran Eric","Wiltfang Jens","D'Hooge Rudi","De Strooper Bart"],"firstAuthor":"Serneels Lutgarde"},{"lsid":"urn:lsid:swan.org:researchstatement:d1666b58-3841-41c8-8a70-8e51ed93408a","title":"Neocortical Disconnection Hypothesis of Alzheimer Disease:  Alzheimer disease is a laminar, regional and neural system specific disease, not a global brain disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1990","id":"urn:lsid:swan.org:researchstatement:d1666b58-3841-41c8-8a70-8e51ed93408a","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d1666b58-3841-41c8-8a70-8e51ed93408a&referrerLinkLabel=hypothesislist","label":"Van Hoesen G et al.; Neocortical Disconnection Hypothesis of ...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Hyman B T"],"firstAuthor":"Van Hoesen G W","taxonomy":["Synapses"],"referenceYear":"1990"},{"lsid":"urn:lsid:swan.org:researchstatement:232db995-9a03-4a77-83ff-11b2e411985f","title":"A generalized excitotoxic mechanism leads to selective cell type vulnerability in Alzheimer's disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1989","id":"urn:lsid:swan.org:researchstatement:232db995-9a03-4a77-83ff-11b2e411985f","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:232db995-9a03-4a77-83ff-11b2e411985f&referrerLinkLabel=hypothesislist","label":"May P; A generalized excitotoxic mechanism lead...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","firstAuthor":"May P C","taxonomy":["Synapses"],"referenceYear":"1989"},{"lsid":"urn:lsid:swan.org:researchstatement:4f222107-e686-40b4-b3c2-45ca75c30290","title":"Staging of Alzheimer-related cortical destruction: progression of tau pathology represents the morphological counterpart of clinically incipient Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1993","id":"urn:lsid:swan.org:researchstatement:4f222107-e686-40b4-b3c2-45ca75c30290","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4f222107-e686-40b4-b3c2-45ca75c30290&referrerLinkLabel=hypothesislist","label":"Braak H et al.; Staging of Alzheimer-related cortical de...","HotTopics":["Failure of axonal transport might be the underlying basis for neurodegeneration in Alzheimer Disease","Tau dysfunction mediates neurodegeneration"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Braak E","Bohl J"],"firstAuthor":"Braak H","taxonomy":["Cytoskeletal Proteins"],"referenceYear":"1993"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:607f4fa6-5204-44ac-81c5-b3957f9f2855\" title=\"Gene: MAPT microtubule-associated protein tau [Homo sapiens]\">MAPT<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:772ce683-db38-4093-8da4-89141e8768ae\" title=\"Protein: Cell division protein kinase 5 [Homo sapiens]\">Cell division protein kinase 5<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:71d4923f-2515-48c4-8c49-67c7222a3239\" title=\"Protein: Glycogen synthase kinase-3 alpha [Homo sapiens]\">Glycogen synthase kinase-3 alpha<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b4f3109c-0624-4096-be2d-b75fd6598c31\" title=\"Protein: Glycogen synthase kinase-3 beta [Homo sapiens]\">Glycogen synthase kinase-3 beta<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:9449c4a8-ef5c-4082-bb7d-0b2a3e3972bb\" title=\"Protein: Proto-oncogene tyrosine-protein kinase Fyn [Homo sapiens]\">Proto-oncogene tyrosine-protein kinase Fyn<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:03f17701-b3b3-4b03-ae1b-31cb82ddf071&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Tau-linked disease processes drive the onset and progression of AD and related tauopathies.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:03f17701-b3b3-4b03-ae1b-31cb82ddf071&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":2,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:03f17701-b3b3-4b03-ae1b-31cb82ddf071&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:03f17701-b3b3-4b03-ae1b-31cb82ddf071","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:03f17701-b3b3-4b03-ae1b-31cb82ddf071&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Synaptic loss appears to be the most powerful and ubiquitous proximate factor leading to the dementia of Alzheimer Disease","Tau dysfunction mediates neurodegeneration"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":8,"containedwithoutevidence":0,"referenceYear":"2007","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:03f17701-b3b3-4b03-ae1b-31cb82ddf071&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:03f17701-b3b3-4b03-ae1b-31cb82ddf071","containedwithevidence":21,"type":"Hypothesis","contained":21,"status":"Extended Annotation","referenceDate":"2007-09","containedevidencecount":108,"alternativeto":6,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:03f17701-b3b3-4b03-ae1b-31cb82ddf071&referrerLinkLabel=hypothesislist","label":"Ballatore C et al.; Tau-linked disease processes drive the o...","otherAuthors":["Lee Virginia M-Y","Trojanowski John Q"],"firstAuthor":"Ballatore Carlo"},{"lsid":"urn:lsid:swan.org:researchstatement:8a5e690b-e551-45d4-93eb-61b046a9866f","title":"Alzheimer disease is a hippocampal dementia.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1977-02-28","id":"urn:lsid:swan.org:researchstatement:8a5e690b-e551-45d4-93eb-61b046a9866f","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8a5e690b-e551-45d4-93eb-61b046a9866f&referrerLinkLabel=hypothesislist","label":"Ball M; Alzheimer disease is a hippocampal demen...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","firstAuthor":"Ball M J","taxonomy":["Inflammation"],"referenceYear":"1977"},{"lsid":"urn:lsid:swan.org:researchstatement:f276081e-cb1d-490e-815f-4aa1cf66befd","title":"Glucocorticoid Hypothesis: Exposure of brain cells to glucocorticoids can increase brain cell loss during aging.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1994","id":"urn:lsid:swan.org:researchstatement:f276081e-cb1d-490e-815f-4aa1cf66befd","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f276081e-cb1d-490e-815f-4aa1cf66befd&referrerLinkLabel=hypothesislist","label":"Landfield P; Glucocorticoid Hypothesis: Exposure of b...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","firstAuthor":"Landfield P W","taxonomy":["Hormones"],"referenceYear":"1994"},{"lsid":"urn:lsid:swan.org:researchstatement:8ecb1d5a-14ff-49b6-b68a-43d0e66bbaca","title":"Impaired brain microcirculation may trigger Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1994","id":"urn:lsid:swan.org:researchstatement:8ecb1d5a-14ff-49b6-b68a-43d0e66bbaca","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8ecb1d5a-14ff-49b6-b68a-43d0e66bbaca&referrerLinkLabel=hypothesislist","label":"de la Torre J; Impaired brain microcirculation may trig...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","firstAuthor":"de la Torre J C","taxonomy":["Circulation"],"referenceYear":"1994"},{"lsid":"urn:lsid:swan.org:researchstatement:d75aab8c-cc41-4c71-806b-ac7b81fe2b56","title":"Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1999-06-25","id":"urn:lsid:swan.org:researchstatement:d75aab8c-cc41-4c71-806b-ac7b81fe2b56","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d75aab8c-cc41-4c71-806b-ac7b81fe2b56&referrerLinkLabel=hypothesislist","label":"Yamin R et al.; Metalloendopeptidase EC 3.4.24.15 is nec...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Malgeri E G","Sloane J A","McGraw W T","Abraham C R"],"firstAuthor":"Yamin R","referenceYear":"1999"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:13a039a0-fd28-45c9-ba65-70f5fbb3630d\" title=\"Protein: STIP1 homology and U box-containing protein 1 [Homo sapiens]\">STIP1 homology and U box-containing protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3bb8873a-be14-43d7-bc18-f2d759e196f5\" title=\"Protein: Heat shock 70 kDa protein 1 [Homo sapiens]\">Heat shock 70 kDa protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e4a1caaf-a0d8-48e2-96e8-e794853ec28e\" title=\"Gene: MIR128-1 microRNA 128-1 [Homo sapiens]\">MIR128-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:bbb5e131-0f89-423d-8017-2475693743f7\" title=\"Protein: BAG family molecular chaperone regulator 2 [Homo sapiens]\">BAG family molecular chaperone regulator 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d1b70427-57d3-4d6d-951d-9fc185717d9c\" title=\"Protein: Alpha-synuclein [Homo sapiens]\">Alpha-synuclein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:fe8920d7-5e5e-4c60-a493-ba4b82e3fa9b\" title=\"Protein: Eukaryotic translation initiation factor 3 subunit A [Homo sapiens]\">Eukaryotic translation initiation factor 3 subunit A<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:8b256371-68d2-4d53-ab08-bbad8e1ce04a\" title=\"Protein: Cyclin-dependent kinase inhibitor 1 [Homo sapiens]\">Cyclin-dependent kinase inhibitor 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:4df78a0d-3593-4a77-8faa-f48b95425946\" title=\"Protein: Cellular tumor antigen p53 [Homo sapiens]\">Cellular tumor antigen p53<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:0ce478ea-91f0-4a70-8bf2-6d8de39374d8\" title=\"Protein: BAG family molecular chaperone regulator 1 [Homo sapiens]\">BAG family molecular chaperone regulator 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:c30bf4cc-d7ac-4530-be7d-d9995339ad7e\" title=\"Protein: Glucocorticoid receptor [Homo sapiens]\">Glucocorticoid receptor<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a635dd07-1a43-4d19-be20-c900e5e0276d\" title=\"Protein: BAG family molecular chaperone regulator 2 [Mus musculus]\">BAG family molecular chaperone regulator 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:4157aba8-37ae-4e10-a49f-07e7ed7b2761\" title=\"Protein: STIP1 homology and U box-containing protein 1 [Mus musculus]\">STIP1 homology and U box-containing protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e02dc3a7-d334-4ba4-9474-5dadce8ca9f6\" title=\"Protein: Microtubule-associated protein tau [Mus musculus]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:1ba51781-3d5e-4938-9754-1a2f174e36eb\" title=\"Protein: Heat shock protein HSP 90-alpha [Mus musculus]\">Heat shock protein HSP 90-alpha<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d0254c95-6172-4f5b-84a8-5511182615f5\" title=\"Protein: Heat shock 70 kDa protein 1A [Mus musculus]\">Heat shock 70 kDa protein 1A<\/a>; ","relatedToOthers":"true","title":"Cochaperone BAG2 sweeps insoluble and phosphorylated tau from the microtubule to ubiquitin-independent protein degradation.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8e35d0bf-a89b-400f-a5b8-67981b19e129&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8e35d0bf-a89b-400f-a5b8-67981b19e129&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:8e35d0bf-a89b-400f-a5b8-67981b19e129","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8e35d0bf-a89b-400f-a5b8-67981b19e129&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Tau dysfunction mediates neurodegeneration","Signaling mechanisms play a critical role in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":1,"containedwithoutevidence":0,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8e35d0bf-a89b-400f-a5b8-67981b19e129&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:8e35d0bf-a89b-400f-a5b8-67981b19e129","containedwithevidence":18,"type":"Hypothesis","contained":18,"status":"Extended Annotation","referenceDate":"2009-02-18","containedevidencecount":36,"alternativeto":2,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8e35d0bf-a89b-400f-a5b8-67981b19e129&referrerLinkLabel=hypothesislist","label":"Carrettiero D et al.; Cochaperone BAG2 sweeps insoluble and ph...","otherAuthors":["Hernandez Israel","Neveu Pierre","Papagiannakopoulos Thales","Kosik Kenneth S"],"firstAuthor":"Carrettiero Daniel C"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:155f1761-aeb1-4901-b030-eee80a0ef8ec&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:155f1761-aeb1-4901-b030-eee80a0ef8ec&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Amyloid-beta and its ability to disrupt intracellular calcium plays a key role in the process of synaptic dysfunction.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:155f1761-aeb1-4901-b030-eee80a0ef8ec&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":3,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:155f1761-aeb1-4901-b030-eee80a0ef8ec&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:155f1761-aeb1-4901-b030-eee80a0ef8ec","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:155f1761-aeb1-4901-b030-eee80a0ef8ec&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Changes in calcium homeostasis may provide a common pathway for the neuropathological changes in AD"],"supportedby":25,"containedwithoutevidence":28,"taxonomy":["Metabolism"],"referenceYear":"2005","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:155f1761-aeb1-4901-b030-eee80a0ef8ec&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:155f1761-aeb1-4901-b030-eee80a0ef8ec","containedwithevidence":68,"type":"Hypothesis","contained":96,"status":"Extended Annotation","referenceDate":"2005","containedevidencecount":103,"alternativeto":6,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:155f1761-aeb1-4901-b030-eee80a0ef8ec&referrerLinkLabel=hypothesislist","label":"Smith I et al.; Amyloid-beta and its ability to disrupt ...","otherAuthors":["Green Kim N","LaFerla Frank M"],"firstAuthor":"Smith I F"},{"lsid":"urn:lsid:swan.org:researchstatement:4e3582b9-1ba5-4dc3-8020-b8fd43bb37ae","title":"Alzheimer disease may represent a brain-specific form of diabetes, Type 3 diabetes.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2006-09","id":"urn:lsid:swan.org:researchstatement:4e3582b9-1ba5-4dc3-8020-b8fd43bb37ae","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4e3582b9-1ba5-4dc3-8020-b8fd43bb37ae&referrerLinkLabel=hypothesislist","label":"de la Monte S et al.; Alzheimer disease may represent a brain-...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Tong Ming","Lester-Coll Nataniel","Plater Michael","Wands Jack R"],"firstAuthor":"de la Monte Suzanne M","taxonomy":["Hormones"],"referenceYear":"2006"},{"lsid":"urn:lsid:swan.org:researchstatement:279d48e0-27eb-415a-9ca1-c9f0e12e1381","title":"Statins reduce risk of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2000-10","id":"urn:lsid:swan.org:researchstatement:279d48e0-27eb-415a-9ca1-c9f0e12e1381","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:279d48e0-27eb-415a-9ca1-c9f0e12e1381&referrerLinkLabel=hypothesislist","label":"Wolozin B et al.; Statins reduce risk of Alzheimer disease...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Kellman W","Ruosseau P","Celesia G G","Siegel G"],"firstAuthor":"Wolozin B","taxonomy":["Trophic Factors"],"referenceYear":"2000"},{"lsid":"urn:lsid:swan.org:researchstatement:66a52c1a-0971-43c8-98ce-4e86e308fa3f","title":"Presenilin gain of function causes early onset autosomal dominant Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1996-10-24","id":"urn:lsid:swan.org:researchstatement:66a52c1a-0971-43c8-98ce-4e86e308fa3f","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:66a52c1a-0971-43c8-98ce-4e86e308fa3f&referrerLinkLabel=hypothesislist","label":"Duff K et al.; Presenilin gain of function causes early...","HotTopics":["Changes in presenilin function lead to dementia and neurodegeneration in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Eckman C","Zehr C","Yu X","Prada C M","Perez-tur J","Hutton M","Buee L","Harigaya Y","Yager D","Morgan D","Gordon M N","Holcomb L","Refolo L","Zenk B","Hardy J","Younkin S"],"firstAuthor":"Duff K","taxonomy":["Protein Processing"],"referenceYear":"1996"},{"lsid":"urn:lsid:swan.org:researchstatement:009410eb-2bab-494f-844e-e76e85a83812","title":"Inappropriate reactivation of the cell cycle is an early and important event in the development of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1996-02","id":"urn:lsid:swan.org:researchstatement:009410eb-2bab-494f-844e-e76e85a83812","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:009410eb-2bab-494f-844e-e76e85a83812&referrerLinkLabel=hypothesislist","label":"Vincent I et al.; Inappropriate reactivation of the cell c...","HotTopics":["The molecular mechanisms of neuronal cell death are involved in the dysfunction and death of neurons in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Rosado M","Davies P"],"firstAuthor":"Vincent I","taxonomy":["Metabolism"],"referenceYear":"1996"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:d673c765-909f-4267-a145-c4d3d555b758\" title=\"Gene: APH1B anterior pharynx defective 1 homolog B (C. elegans) [Homo sapiens]\">APH1B<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:6c62fc4a-b8a2-435c-b0ab-b16a10239342\" title=\"Gene: APH1A anterior pharynx defective 1 homolog A (C. elegans) [Homo sapiens]\">APH1A<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:45dccdee-f207-4e31-9cd2-83bf74aada5e\" title=\"Protein: Gamma-secretase subunit APH-1A [Homo sapiens]\">Gamma-secretase subunit APH-1A<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b3d25d4d-ae3f-4825-89e1-7d207f7a522c\" title=\"Protein: Gamma-secretase subunit APH-1B [Homo sapiens]\">Gamma-secretase subunit APH-1B<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1fc8c0f7-f243-4264-b0a3-1bf2452f13a0&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1fc8c0f7-f243-4264-b0a3-1bf2452f13a0&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Intramembranous Aβ dimer may be toxic.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1fc8c0f7-f243-4264-b0a3-1bf2452f13a0&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":6,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1fc8c0f7-f243-4264-b0a3-1bf2452f13a0&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:1fc8c0f7-f243-4264-b0a3-1bf2452f13a0","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1fc8c0f7-f243-4264-b0a3-1bf2452f13a0&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Aβ accumulation in the brain is the primary event in Alzheimer Disease pathogenesis","Cell membrane properties play a key role in AD Pathophysiology"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":18,"containedwithoutevidence":12,"taxonomy":["Amyloid"],"referenceYear":"2005","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1fc8c0f7-f243-4264-b0a3-1bf2452f13a0&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:1fc8c0f7-f243-4264-b0a3-1bf2452f13a0","containedwithevidence":22,"type":"Hypothesis","contained":34,"status":"Extended Annotation","referenceDate":"2005-06-28","containedevidencecount":41,"alternativeto":12,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1fc8c0f7-f243-4264-b0a3-1bf2452f13a0&referrerLinkLabel=hypothesislist","label":"Marchesi V; Intramembranous Aβ dimer may be toxic.","firstAuthor":"Marchesi Vincent T"},{"lsid":"urn:lsid:swan.org:researchstatement:eb1ef06d-bcae-488e-a411-963e62e2732f","title":"The cystatin C allele CST3-A is a risk factor for early onset Alzheimer Disease.  ","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2001-11-23","id":"urn:lsid:swan.org:researchstatement:eb1ef06d-bcae-488e-a411-963e62e2732f","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:eb1ef06d-bcae-488e-a411-963e62e2732f&referrerLinkLabel=hypothesislist","label":"Beyer K et al.; The cystatin C allele CST3-A is a risk f...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Genetic variants modulate risk of AD"],"otherAuthors":["Lao J I","Gómez M","Riutort N","Latorre P","Mate J L","Ariza A"],"firstAuthor":"Beyer K","referenceYear":"2001"},{"lsid":"urn:lsid:swan.org:researchstatement:c3722ffe-bef6-4e5d-9824-3ef45831f23b","title":"Aβ Cascade Hypothesis: Aβ aggregates lead to Alzheimer disease neurodegeneration.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2006-12","id":"urn:lsid:swan.org:researchstatement:c3722ffe-bef6-4e5d-9824-3ef45831f23b","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c3722ffe-bef6-4e5d-9824-3ef45831f23b&referrerLinkLabel=hypothesislist","label":"Golde T et al.; Aβ Cascade Hypothesis: Aβ aggregates lea...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Dickson Dennis","Hutton Michael"],"firstAuthor":"Golde Todd E","taxonomy":["Amyloid"],"referenceYear":"2006"},{"refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b6be5f2b-888f-4799-b738-7b8e756092b9&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b6be5f2b-888f-4799-b738-7b8e756092b9&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Enhanced peripheral clearance and/or sequestration of soluble Aβ in brain may rapidly reverse memory impairment in AD.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b6be5f2b-888f-4799-b738-7b8e756092b9&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":1,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b6be5f2b-888f-4799-b738-7b8e756092b9&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:b6be5f2b-888f-4799-b738-7b8e756092b9","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b6be5f2b-888f-4799-b738-7b8e756092b9&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Defective mechanisms of Aβ clearance contribute to Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":15,"containedwithoutevidence":6,"referenceYear":"2002","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b6be5f2b-888f-4799-b738-7b8e756092b9&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:b6be5f2b-888f-4799-b738-7b8e756092b9","containedwithevidence":30,"type":"Hypothesis","contained":36,"status":"Extended Annotation","referenceDate":"2002-05","containedevidencecount":50,"alternativeto":9,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b6be5f2b-888f-4799-b738-7b8e756092b9&referrerLinkLabel=hypothesislist","label":"Dodart J et al.; Enhanced peripheral clearance and/or seq...","otherAuthors":["Bales Kelly R","Gannon Kimberley S","Greene Stephen J","DeMattos Ronald B","Mathis Chantal","DeLong Cynthia A","Wu Su","Wu Xin","Holtzman David M","Paul Steven M"],"firstAuthor":"Dodart Jean-Cosme"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a7e46472-89de-4e96-9218-9db4d1e1690d\" title=\"Protein: Neuronal acetylcholine receptor subunit alpha-7 [Homo sapiens]\">Neuronal acetylcholine receptor subunit alpha-7<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f08d50e0-3972-4264-b84a-30f415a2c06f\" title=\"Protein: Mitogen-activated protein kinase 3 [Homo sapiens]\">Mitogen-activated protein kinase 3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b4f3109c-0624-4096-be2d-b75fd6598c31\" title=\"Protein: Glycogen synthase kinase-3 beta [Homo sapiens]\">Glycogen synthase kinase-3 beta<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e336d78e-63d2-4896-b1e0-56eeecba4ab4\" title=\"Gene: Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 [Mus musculus]\">Chrna7<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:81c45ac5-97d8-4897-a5b5-e1ebbaf0183f\" title=\"Protein: Glycogen synthase kinase-3 beta [Mus musculus]\">Glycogen synthase kinase-3 beta<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4ddd589d-863f-40e2-9862-47ccd94736f5&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4ddd589d-863f-40e2-9862-47ccd94736f5&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"The α7 Nicotinic Acetylcholine Receptor gene mediates cognitive deficits and synaptic pathology.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4ddd589d-863f-40e2-9862-47ccd94736f5&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":1,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4ddd589d-863f-40e2-9862-47ccd94736f5&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:4ddd589d-863f-40e2-9862-47ccd94736f5","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4ddd589d-863f-40e2-9862-47ccd94736f5&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Synaptic loss appears to be the most powerful and ubiquitous proximate factor leading to the dementia of Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":11,"containedwithoutevidence":2,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4ddd589d-863f-40e2-9862-47ccd94736f5&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:4ddd589d-863f-40e2-9862-47ccd94736f5","containedwithevidence":26,"type":"Hypothesis","contained":28,"status":"Extended Annotation","referenceDate":"2009-07-08","containedevidencecount":51,"alternativeto":4,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4ddd589d-863f-40e2-9862-47ccd94736f5&referrerLinkLabel=hypothesislist","label":"Dziewczapolski G et al.; The α7 Nicotinic Acetylcholine Receptor ...","otherAuthors":["Glogowski Carolina M","Masliah Eliezer","Heinemann Stephen F"],"firstAuthor":"Dziewczapolski Gustavo"},{"lsid":"urn:lsid:swan.org:researchstatement:3fe61b6b-7d7c-458c-8b92-d6d3d93978e1","title":"Alzheimer changes in hypothalamic nuclei: Their relationship to neuronal activity and clinical symptoms.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1994-12","id":"urn:lsid:swan.org:researchstatement:3fe61b6b-7d7c-458c-8b92-d6d3d93978e1","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:3fe61b6b-7d7c-458c-8b92-d6d3d93978e1&referrerLinkLabel=hypothesislist","label":"Lucassen P et al.; Alzheimer changes in hypothalamic nuclei...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Salehi A","Pool C W","Gonatas N K","Swaab D F"],"firstAuthor":"Lucassen P J","referenceYear":"1994"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c55e79aa-db18-463d-90af-27500c9661dd&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c55e79aa-db18-463d-90af-27500c9661dd&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":1,"id":"urn:lsid:swan.org:researchstatement:c55e79aa-db18-463d-90af-27500c9661dd","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c55e79aa-db18-463d-90af-27500c9661dd&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Insoluble fibrillar Aβ leads to AD","Changes in calcium homeostasis may provide a common pathway for the neuropathological changes in AD"],"supportedby":4,"containedwithoutevidence":0,"taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"2008","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c55e79aa-db18-463d-90af-27500c9661dd&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:c55e79aa-db18-463d-90af-27500c9661dd","containedwithevidence":10,"type":"Hypothesis","contained":10,"status":"Extended Annotation","referenceDate":"2008-07-31","containedevidencecount":26,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c55e79aa-db18-463d-90af-27500c9661dd&referrerLinkLabel=hypothesislist","label":"Kuchibhotla K et al.; Aβ Plaques Lead to Aberrant Regulation o...","otherAuthors":["Goldman Samuel T","Lattarulo Carli R","Wu Hai-Yan","Hyman Bradley T","Bacskai Brian J"],"firstAuthor":"Kuchibhotla Kishore V"},{"lsid":"urn:lsid:swan.org:researchstatement:c199c5b7-1aa1-4884-8340-e12386d31aa3","title":"Systemic inflammation, infection and ApoE4 are associated with Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2007-04","id":"urn:lsid:swan.org:researchstatement:c199c5b7-1aa1-4884-8340-e12386d31aa3","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c199c5b7-1aa1-4884-8340-e12386d31aa3&referrerLinkLabel=hypothesislist","label":"Finch C et al.; Systemic inflammation, infection and Apo...","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Morgan Todd E"],"firstAuthor":"Finch Caleb E","taxonomy":["Inflammation"],"referenceYear":"2007"},{"containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e35c6490-f915-44de-8366-3cb55b566354&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","containedwithevidence":16,"lsid":"urn:lsid:swan.org:researchstatement:e35c6490-f915-44de-8366-3cb55b566354","title":"[ADNI]  Models of Alzheimer Disease Biomarkers: Disease stage and clinical symptom severity are related to dynamic changes of biomarkers.","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e35c6490-f915-44de-8366-3cb55b566354&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":21,"status":"Extended Annotation","id":"urn:lsid:swan.org:researchstatement:e35c6490-f915-44de-8366-3cb55b566354","containedevidencecount":37,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e35c6490-f915-44de-8366-3cb55b566354&referrerLinkLabel=hypothesislist","label":"Jack C et al.; [ADNI]  Models of Alzheimer Disease Biom...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Biomarkers are useful for predicting and staging Alzheimer disease"],"otherAuthors":["Knopman David S","Jagust William J","Shaw Leslie M","Aisen Paul S","Weiner Michael W","Petersen Ronald C","Trojanowski John Q"],"containedwithoutevidence":5,"firstAuthor":"Jack Clifford R","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e35c6490-f915-44de-8366-3cb55b566354&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsid":"urn:lsid:swan.org:researchstatement:c8f20507-b774-4b59-b2f7-b9ec4a596ff7","title":"BACE1 overactivity occurs in sporadic Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2002-09","id":"urn:lsid:swan.org:researchstatement:c8f20507-b774-4b59-b2f7-b9ec4a596ff7","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:c8f20507-b774-4b59-b2f7-b9ec4a596ff7&referrerLinkLabel=hypothesislist","label":"Fukumoto H et al.; BACE1 overactivity occurs in sporadic Al...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Cheung Bonnie S","Hyman Bradley T","Irizarry Michael C"],"firstAuthor":"Fukumoto Hiroaki","taxonomy":["Protein Processing"],"referenceYear":"2002"},{"lsid":"urn:lsid:swan.org:researchstatement:d0b8ecf6-ab14-4202-a24e-2575c93ba49e","title":"Alpha-1 antichymotripsin contributes to the development of amyloid deposits.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1988-02-26","id":"urn:lsid:swan.org:researchstatement:d0b8ecf6-ab14-4202-a24e-2575c93ba49e","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d0b8ecf6-ab14-4202-a24e-2575c93ba49e&referrerLinkLabel=hypothesislist","label":"Abraham C et al.; Alpha-1 antichymotripsin contributes to ...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Selkoe D J","Potter H"],"firstAuthor":"Abraham C R","taxonomy":["Protease Activation"],"referenceYear":"1988"},{"lsid":"urn:lsid:swan.org:researchstatement:6e075df7-0eef-4d42-9c2a-95124a75471d","title":"LRP is the major neuronal receptor of Aβ-ApoE complexes and mediates Aβ neurotoxicity.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1996","id":"urn:lsid:swan.org:researchstatement:6e075df7-0eef-4d42-9c2a-95124a75471d","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:6e075df7-0eef-4d42-9c2a-95124a75471d&referrerLinkLabel=hypothesislist","label":"Tanzi R et al.; LRP is the major neuronal receptor of Aβ...","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Kovacs D M","Kim T W","Moir R D","Guenette S Y","Wasco W"],"firstAuthor":"Tanzi R E","taxonomy":["ApoE"],"referenceYear":"1996"},{"lsid":"urn:lsid:swan.org:researchstatement:4fd140c4-889d-4451-a42f-1e513bf79739","title":"Cholinergic Hypothesis of Alzheimer Disease:  Alzheimer disease is the result of a breakdown of central cholinergic transmission.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1980-02","id":"urn:lsid:swan.org:researchstatement:4fd140c4-889d-4451-a42f-1e513bf79739","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4fd140c4-889d-4451-a42f-1e513bf79739&referrerLinkLabel=hypothesislist","label":"Perry E; Cholinergic Hypothesis of Alzheimer Dise...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","firstAuthor":"Perry E K","taxonomy":["Synapses"],"referenceYear":"1980"},{"lsid":"urn:lsid:swan.org:researchstatement:58a37f73-db78-41e0-a536-14be683d9356","title":"Ion channel activity of the amyloid beta polypeptide may be the basis of its neurotoxic effects.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1993-09-24","id":"urn:lsid:swan.org:researchstatement:58a37f73-db78-41e0-a536-14be683d9356","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:58a37f73-db78-41e0-a536-14be683d9356&referrerLinkLabel=hypothesislist","label":"Pollard H et al.; Ion channel activity of the amyloid beta...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Rojas E","Arispe N"],"firstAuthor":"Pollard H B","referenceYear":"1993"},{"refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a131f691-79c1-41f7-baa4-f8d87a9fe05e&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a131f691-79c1-41f7-baa4-f8d87a9fe05e&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Synapse loss is the physical basis and major correlate of cognitive impairment in Alzheimer Disease.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a131f691-79c1-41f7-baa4-f8d87a9fe05e&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":3,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a131f691-79c1-41f7-baa4-f8d87a9fe05e&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:a131f691-79c1-41f7-baa4-f8d87a9fe05e","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a131f691-79c1-41f7-baa4-f8d87a9fe05e&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Synaptic loss appears to be the most powerful and ubiquitous proximate factor leading to the dementia of Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":7,"containedwithoutevidence":1,"referenceYear":"1991","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a131f691-79c1-41f7-baa4-f8d87a9fe05e&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:a131f691-79c1-41f7-baa4-f8d87a9fe05e","containedwithevidence":6,"type":"Hypothesis","contained":7,"status":"Extended Annotation","referenceDate":"1991-10","containedevidencecount":13,"alternativeto":6,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a131f691-79c1-41f7-baa4-f8d87a9fe05e&referrerLinkLabel=hypothesislist","label":"Terry R et al.; Synapse loss is the physical basis and m...","otherAuthors":["Masliah Eliezer","Salmon D P","Butters N","DeTeresa R","Hill R","Hansen L A","Katzman R"],"firstAuthor":"Terry R D"},{"lsid":"urn:lsid:swan.org:researchstatement:e65b31d4-3ab1-4235-9b1b-7987acf74034","title":"Insulin-degrading enzyme is the main soluble beta-amyloid degrading enzyme.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2003-04-01","id":"urn:lsid:swan.org:researchstatement:e65b31d4-3ab1-4235-9b1b-7987acf74034","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e65b31d4-3ab1-4235-9b1b-7987acf74034&referrerLinkLabel=hypothesislist","label":"Farris W et al.; Insulin-degrading enzyme is the main sol...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Defective mechanisms of Aβ clearance contribute to Alzheimer Disease"],"otherAuthors":["Mansourian Stefan","Chang Yang","Lindsley Loren","Eckman Elizabeth A","Frosch Matthew P","Eckman Christopher B","Tanzi Rudolph E","Selkoe Dennis J","Guenette Suzanne"],"firstAuthor":"Farris Wesley","referenceYear":"2003"},{"lsid":"urn:lsid:swan.org:researchstatement:d2eb250a-0bcd-4c5f-87d8-bb7f334dbf91","title":"ApoE and LRP colocalize to and may be involved in the metabolism of amyloid plaques.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1993-10","id":"urn:lsid:swan.org:researchstatement:d2eb250a-0bcd-4c5f-87d8-bb7f334dbf91","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d2eb250a-0bcd-4c5f-87d8-bb7f334dbf91&referrerLinkLabel=hypothesislist","label":"Rebeck G et al.; ApoE and LRP colocalize to and may be in...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"otherAuthors":["Reiter J S","Strickland D K","Hyman B T"],"firstAuthor":"Rebeck G W","referenceYear":"1993"},{"lsid":"urn:lsid:swan.org:researchstatement:5c5f920c-74b1-4bea-bf14-de4aeba7476c","title":"Amyloid Cascade Hypothesis:  The neurodegeneration of Alzheimer Disease is caused by Aβ deposited into plaques in brain tissue.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1992-04-10","id":"urn:lsid:swan.org:researchstatement:5c5f920c-74b1-4bea-bf14-de4aeba7476c","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:5c5f920c-74b1-4bea-bf14-de4aeba7476c&referrerLinkLabel=hypothesislist","label":"Hardy J et al.; Amyloid Cascade Hypothesis:  The neurode...","HotTopics":["Aβ accumulation in the brain is the primary event in Alzheimer Disease pathogenesis"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Higgins G A"],"firstAuthor":"Hardy J","taxonomy":["Amyloid"],"referenceYear":"1992"},{"lsid":"urn:lsid:swan.org:researchstatement:297b4e7c-c3a7-4298-8946-9e9d0535a2fa","title":"TGF-beta may contribute to the formation of amyloid plaques in Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1995-07","id":"urn:lsid:swan.org:researchstatement:297b4e7c-c3a7-4298-8946-9e9d0535a2fa","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:297b4e7c-c3a7-4298-8946-9e9d0535a2fa&referrerLinkLabel=hypothesislist","label":"Wyss-Coray T et al.; TGF-beta may contribute to the formation...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Feng L","Masliah E","Ruppe M D","Lee H S","Toggas S M","Rockenstein E M","Mucke L"],"firstAuthor":"Wyss-Coray T","taxonomy":["Trophic Factors"],"referenceYear":"1995"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>; ","containedwithevidence":27,"lsid":"urn:lsid:swan.org:researchstatement:3914ace0-559d-4ce8-918c-1a3bacd25e4c","title":"β-Amyloid Monomers Are Neuroprotective.","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:3914ace0-559d-4ce8-918c-1a3bacd25e4c&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":27,"status":"Extended Annotation","referenceDate":"2009-08-26","id":"urn:lsid:swan.org:researchstatement:3914ace0-559d-4ce8-918c-1a3bacd25e4c","containedevidencecount":44,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:3914ace0-559d-4ce8-918c-1a3bacd25e4c&referrerLinkLabel=hypothesislist","label":"Giuffrida M et al.; β-Amyloid Monomers Are Neuroprotective.","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Aβ accumulation in the brain is the primary event in Alzheimer Disease pathogenesis"],"otherAuthors":["Caraci Filippo","Pignataro Bruno","Cataldo Sebastiano","De Bona Paolo","Bruno Valeria","Molinaro Gemma","Pappalardo Giuseppe","Messina Angela","Palmigiano Angelo","Garozzo Domenico","Nicoletti Ferdinando","Rizzarelli Enrico","Copani Agata"],"containedwithoutevidence":0,"firstAuthor":"Giuffrida Maria Laura","referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:3914ace0-559d-4ce8-918c-1a3bacd25e4c&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:2ba06a20-f60c-498c-86e4-9d8f2ed1e7df\" title=\"Gene: GAB2 GRB2-associated binding protein 2 [Homo sapiens]\">GAB2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:cfdaa5e5-f0e7-43f1-9347-558c2044dee8\" title=\"Gene: PSEN2 presenilin 2 (Alzheimer disease 4) [Homo sapiens]\">PSEN2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:72d96e09-f773-4932-a011-37b74572ec2d\" title=\"Protein: GRB2-associated-binding protein 2 [Homo sapiens]\">GRB2-associated-binding protein 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b4f3109c-0624-4096-be2d-b75fd6598c31\" title=\"Protein: Glycogen synthase kinase-3 beta [Homo sapiens]\">Glycogen synthase kinase-3 beta<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>; ","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:45b6d8a0-c193-49a7-bf56-8e30e2a2f4a9&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","containedwithevidence":10,"lsid":"urn:lsid:swan.org:researchstatement:45b6d8a0-c193-49a7-bf56-8e30e2a2f4a9","title":"GAB2 alleles modify Alzheimer\u2019s risk in APOE ε4 carriers.  ","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:45b6d8a0-c193-49a7-bf56-8e30e2a2f4a9&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":11,"status":"Extended Annotation","referenceDate":"2007-06-07","id":"urn:lsid:swan.org:researchstatement:45b6d8a0-c193-49a7-bf56-8e30e2a2f4a9","containedevidencecount":23,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:45b6d8a0-c193-49a7-bf56-8e30e2a2f4a9&referrerLinkLabel=hypothesislist","label":"Reiman E et al.; GAB2 alleles modify Alzheimer\u2019s risk in ...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Genetic variants modulate risk of AD"],"otherAuthors":["Webster Jennifer A","Myers Amanda J","Hardy John","Dunckley Travis","Zismann Victoria L","Joshipura Keta D","Pearson John V","Hu-Lince Diane","Huentelman Matthew J","Craig David W","Coon Keith D","Liang Winnie S","Herbert RiLee H","Beach Thomas","Rohrer Kristen C","Zhao Alice S","Leung Doris","Bryden Leslie","Marlowe Lauren","Kaleem Mona","Mastroeni Diego","Grover Andrew","Heward Christopher B","Ravid Rivka","Rogers Joseph","Hutton Michael L","Melquist Stacey","Petersen Ron C","Alexander Gene E","Caselli Richard J","Kukull Walter","Papassotiropoulos Andreas","Stephan Dietrich A"],"containedwithoutevidence":1,"firstAuthor":"Reiman Eric M","referenceYear":"2007","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:45b6d8a0-c193-49a7-bf56-8e30e2a2f4a9&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:9ce8f0a7-82ea-4f3a-bb09-3128ebd21614\" title=\"Protein: G1/S-specific cyclin-D1 [Mus musculus]\">G1/S-specific cyclin-D1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:15b118a2-7bc9-4ccc-95f3-0cfa2aa17102\" title=\"Protein: Cyclin-A1 [Mus musculus]\">Cyclin-A1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:09e6b855-66d3-4a34-957c-a777c96f6111\" title=\"Gene: Atm ataxia telangiectasia mutated homolog (human) [Mus musculus]\">Atm<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:cfe3ee10-5b71-4aff-94a0-965047200b0d\" title=\"Gene: E2f1 E2F transcription factor 1 [Mus musculus]\">E2f1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:16201340-db4d-4b71-93c0-c6b31e2184b8\" title=\"Protein: Microtubule-associated protein 2 [Mus musculus]\">Microtubule-associated protein 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:d789554a-ffd2-4af5-a899-de2a05defcee\" title=\"Gene: Bace1 beta-site APP cleaving enzyme 1 [Mus musculus]\">Bace1<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:07ff2b33-4102-4e4e-a315-68930b20d06a&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:07ff2b33-4102-4e4e-a315-68930b20d06a&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Aβ oligomers induce neuronal cell cycle events in Alzheimer disease.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:07ff2b33-4102-4e4e-a315-68930b20d06a&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":1,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:07ff2b33-4102-4e4e-a315-68930b20d06a&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:07ff2b33-4102-4e4e-a315-68930b20d06a","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:07ff2b33-4102-4e4e-a315-68930b20d06a&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Soluble oligomeric aggregates of Aβ are toxic to neurons and cause AD pathology","The molecular mechanisms of neuronal cell death are involved in the dysfunction and death of neurons in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":6,"containedwithoutevidence":3,"referenceYear":"2008","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:07ff2b33-4102-4e4e-a315-68930b20d06a&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:07ff2b33-4102-4e4e-a315-68930b20d06a","containedwithevidence":17,"type":"Hypothesis","contained":20,"status":"Extended Annotation","referenceDate":"2008-10-22","containedevidencecount":52,"alternativeto":2,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:07ff2b33-4102-4e4e-a315-68930b20d06a&referrerLinkLabel=hypothesislist","label":"Varvel N et al.; Aβ oligomers induce neuronal cell cycle ...","otherAuthors":["Bhaskar Kiran","Patil Anita R","Pimplikar Sanjay W","Herrup Karl","Lamb Bruce T"],"firstAuthor":"Varvel Nicholas H"},{"lsid":"urn:lsid:swan.org:researchstatement:4e61e620-5ed7-43df-aabf-e4e488f45239","title":"By using Down syndrome tissue the development of Alzheimer disease may be studied by examining the expression of ALZ-50 positive tau protein.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1988-08","id":"urn:lsid:swan.org:researchstatement:4e61e620-5ed7-43df-aabf-e4e488f45239","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4e61e620-5ed7-43df-aabf-e4e488f45239&referrerLinkLabel=hypothesislist","label":"Wolozin B et al.; By using Down syndrome tissue the develo...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Scicutella A","Davies P"],"firstAuthor":"Wolozin B","taxonomy":["Cytoskeletal Proteins"],"referenceYear":"1988"},{"lsid":"urn:lsid:swan.org:researchstatement:4b98d495-2d61-4fe4-8fb0-9c1657792327","title":"Cdk5/p25 is involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1999-12-09","id":"urn:lsid:swan.org:researchstatement:4b98d495-2d61-4fe4-8fb0-9c1657792327","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:4b98d495-2d61-4fe4-8fb0-9c1657792327&referrerLinkLabel=hypothesislist","label":"Patrick G et al.; Cdk5/p25 is involved in the pathogenesis...","HotTopics":["Failure of axonal transport might be the underlying basis for neurodegeneration in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Zukerberg L","Nikolic M","de la Monte S","Dikkes P","Tsai L H"],"firstAuthor":"Patrick G N","taxonomy":["Cytoskeletal Proteins"],"referenceYear":"1999"},{"lsid":"urn:lsid:swan.org:researchstatement:b5a62739-66a4-44f8-9464-7b95920a6306","title":"AMPA binding sites are reduced in Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1991-07-05","id":"urn:lsid:swan.org:researchstatement:b5a62739-66a4-44f8-9464-7b95920a6306","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b5a62739-66a4-44f8-9464-7b95920a6306&referrerLinkLabel=hypothesislist","label":"Dewar D et al.; AMPA binding sites are reduced in Alzhei...","HotTopics":["Cell membrane properties play a key role in AD Pathophysiology"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Chalmers D T","Graham D I","McCulloch J"],"firstAuthor":"Dewar D","taxonomy":["Synapses"],"referenceYear":"1991"},{"lsid":"urn:lsid:swan.org:researchstatement:f461a9f8-8044-43f4-aab3-c0afe843fd3e","title":"Excitatory neurotransmitter receptor dysfunction contributes to symptomatology and excitotoxicity of Alzheimer Disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1990","id":"urn:lsid:swan.org:researchstatement:f461a9f8-8044-43f4-aab3-c0afe843fd3e","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f461a9f8-8044-43f4-aab3-c0afe843fd3e&referrerLinkLabel=hypothesislist","label":"Jansen K et al.; Excitatory neurotransmitter receptor dys...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Faull R L","Dragunow M","Synek B L"],"firstAuthor":"Jansen K L","referenceYear":"1990"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:423bfe3a-9193-45cb-a7f5-191ec727b920\" title=\"Protein: Thimet oligopeptidase [Homo sapiens]\">Thimet oligopeptidase<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e78291f1-6a80-4aa8-b80e-d63a151e2ae9\" title=\"Protein: Angiotensin-converting enzyme, somatic isoform [Homo sapiens]\">Angiotensin-converting enzyme, somatic isoform<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:3092884e-2001-4043-b404-08efc325ec43\" title=\"Gene: THOP1 thimet oligopeptidase 1 [Homo sapiens]\">THOP1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:7c634f82-7b9e-4d73-986f-38b5ff825f82\" title=\"Gene: BCL2 B-cell CLL/lymphoma 2 [Homo sapiens]\">BCL2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Rattus norvegicus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:8899581b-dfe8-436d-930d-1d89d64f4979\" title=\"Protein: Thimet oligopeptidase [Rattus norvegicus]\">Thimet oligopeptidase<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:289ce159-e13e-4ae7-a630-033918c10231\" title=\"Protein: Thimet oligopeptidase [Mus musculus]\">Thimet oligopeptidase<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:677c40f2-f45a-4c89-baa0-3134a48364e1\" title=\"Protein: Angiotensin-converting enzyme, somatic isoform [Mus musculus]\">Angiotensin-converting enzyme, somatic isoform<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:cc9a7157-7d93-4071-ba6a-a67bcbad23e6\" title=\"Gene: Thop1 thimet oligopeptidase 1 [Mus musculus]\">Thop1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e02dc3a7-d334-4ba4-9474-5dadce8ca9f6\" title=\"Protein: Microtubule-associated protein tau [Mus musculus]\">Microtubule-associated protein tau<\/a>; ","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d35e96d7-7f3c-43e2-ba64-a880dc476b13&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Aβ toxicity. ","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d35e96d7-7f3c-43e2-ba64-a880dc476b13&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d35e96d7-7f3c-43e2-ba64-a880dc476b13&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:d35e96d7-7f3c-43e2-ba64-a880dc476b13","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d35e96d7-7f3c-43e2-ba64-a880dc476b13&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Defective mechanisms of Aβ clearance contribute to Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":4,"containedwithoutevidence":2,"referenceYear":"2008","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d35e96d7-7f3c-43e2-ba64-a880dc476b13&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:d35e96d7-7f3c-43e2-ba64-a880dc476b13","containedwithevidence":28,"type":"Hypothesis","contained":30,"status":"Extended Annotation","referenceDate":"2008-07","containedevidencecount":44,"alternativeto":1,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d35e96d7-7f3c-43e2-ba64-a880dc476b13&referrerLinkLabel=hypothesislist","label":"Pollio G et al.; Increased expression of the oligopeptida...","otherAuthors":["Hoozemans Jeroen J","Andersen Claus A","Roncarati Renza","Rosi Maria Cristina","van Haastert Elise S","Seredenina Tamara","Diamanti Daniela","Gotta Stefano","Fiorentini Anna","Magnoni Letizia","Raggiaschi Roberto","Rozemuller Annemieke J","Casamenti Fiorella","Caricasole Andrea","Terstappen Georg C"],"firstAuthor":"Pollio Giuseppe"},{"refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ea2b77ca-258c-4cd2-8dd7-5b291e65aa5c&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ea2b77ca-258c-4cd2-8dd7-5b291e65aa5c&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Aβ*56 hypothesis:  A specific amyloid-β protein assembly in the brain impairs memory.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ea2b77ca-258c-4cd2-8dd7-5b291e65aa5c&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":1,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ea2b77ca-258c-4cd2-8dd7-5b291e65aa5c&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:ea2b77ca-258c-4cd2-8dd7-5b291e65aa5c","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ea2b77ca-258c-4cd2-8dd7-5b291e65aa5c&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Soluble oligomeric aggregates of Aβ are toxic to neurons and cause AD pathology"],"supportedby":3,"containedwithoutevidence":7,"taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"2006","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ea2b77ca-258c-4cd2-8dd7-5b291e65aa5c&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:ea2b77ca-258c-4cd2-8dd7-5b291e65aa5c","containedwithevidence":3,"type":"Hypothesis","contained":10,"status":"Extended Annotation","referenceDate":"2006-03-16","containedevidencecount":8,"alternativeto":2,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ea2b77ca-258c-4cd2-8dd7-5b291e65aa5c&referrerLinkLabel=hypothesislist","label":"Lesné S et al.; Aβ*56 hypothesis:  A specific amyloid-β ...","otherAuthors":["Koh Ming Teng","Kotilinek Linda","Kayed Rakez","Glabe Charles G","Yang Austin","Gallagher Michela","Ashe Karen H"],"firstAuthor":"Lesné Sylvain"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:2ed39882-7c4d-407b-8b87-3c12fb464666\" title=\"Protein: Glial fibrillary acidic protein [Mus musculus]\">Glial fibrillary acidic protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:0f0e70da-c7cb-401c-b25b-68dfd1386895\" title=\"Protein: Kinesin-1 heavy chain [Mus musculus]\">Kinesin-1 heavy chain<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:2ae2f637-eebb-4798-a173-fed52e180a9a\" title=\"Protein: Fasciculation and elongation protein zeta-1 [Mus musculus]\">Fasciculation and elongation protein zeta-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:369ddeed-5846-4bf5-8662-7b8d4cffb6e4\" title=\"Protein: C-jun-amino-terminal kinase-interacting protein 3 [Mus musculus]\">C-jun-amino-terminal kinase-interacting protein 3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b41314cf-fdae-4757-a1da-95ae2f7ee0a1\" title=\"Protein: Mitogen-activated protein kinase 10 [Mus musculus]\">Mitogen-activated protein kinase 10<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:01efabf6-1c14-487c-ba24-addd6c79a419\" title=\"Protein: Calsyntenin-1 [Mus musculus]\">Calsyntenin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:ef372485-9418-469f-bf7f-d8b2fa2d627d\" title=\"Protein: Torsin-1A [Mus musculus]\">Torsin-1A<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:5cf12516-2f8b-450e-b113-e645e8c694eb\" title=\"Protein: C-jun-amino-terminal kinase-interacting protein 2 [Mus musculus]\">C-jun-amino-terminal kinase-interacting protein 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:9b5c7146-9c31-497c-ace0-67619211b55f\" title=\"Protein: C-jun-amino-terminal kinase-interacting protein 1 [Mus musculus]\">C-jun-amino-terminal kinase-interacting protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:ba7bdcac-5836-4efe-a0cf-5bad4da54509\" title=\"Protein: Scrapie-responsive protein 1 [Mus musculus]\">Scrapie-responsive protein 1<\/a>; ","containedwithevidence":10,"lsid":"urn:lsid:swan.org:researchstatement:ca7169f1-ff7d-456c-b3f3-c52bec1e8074","relatedToOthers":"true","title":"CAD cells are a useful model for studies of APP cell biology and Alzheimers disease pathology, including Aβ accumulation within neurites.","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ca7169f1-ff7d-456c-b3f3-c52bec1e8074&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":10,"status":"Extended Annotation","id":"urn:lsid:swan.org:researchstatement:ca7169f1-ff7d-456c-b3f3-c52bec1e8074","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ca7169f1-ff7d-456c-b3f3-c52bec1e8074&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","containedevidencecount":70,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ca7169f1-ff7d-456c-b3f3-c52bec1e8074&referrerLinkLabel=hypothesislist","label":"Muresan Z et al.; CAD cells are a useful model for studies...","supportedby":1,"icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Aβ accumulation in the brain is the primary event in Alzheimer Disease pathogenesis"],"otherAuthors":["Muresan Virgil"],"containedwithoutevidence":0,"firstAuthor":"Muresan Zoia","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:ca7169f1-ff7d-456c-b3f3-c52bec1e8074&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsid":"urn:lsid:swan.org:researchstatement:43818b03-1669-4b99-8195-f55b32f972d9","title":"The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer Disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2007-02","id":"urn:lsid:swan.org:researchstatement:43818b03-1669-4b99-8195-f55b32f972d9","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:43818b03-1669-4b99-8195-f55b32f972d9&referrerLinkLabel=hypothesislist","label":"Rogaeva E et al.; The neuronal sortilin-related receptor S...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Genetic variants modulate risk of AD"],"otherAuthors":["Meng Yan","Lee Joseph H","Gu Yongjun","Kawarai Toshitaka","Zou Fanggeng","Katayama Taiichi","Baldwin Clinton T","Cheng Rong","Hasegawa Hiroshi","Chen Fusheng","Shibata Nobuto","Lunetta Kathryn L","Pardossi-Piquard Raphaelle","Bohm Christopher","Wakutani Yosuke","Cupples L Adrienne","Cuenco Karen T","Green Robert C","Pinessi Lorenzo","Rainero Innocenzo","Sorbi Sandro","Bruni Amalia","Duara Ranjan","Friedland Robert P","Inzelberg Rivka","Hampe Wolfgang","Bujo Hideaki","Song You-Qiang","Andersen Olav M","Willnow Thomas E","Graff-Radford Neill","Petersen Ronald C","Dickson Dennis","Der Sandy D","Fraser Paul E","Schmitt-Ulms Gerold","Younkin Steven","Mayeux Richard","Farrer Lindsay A","St George-Hyslop Peter"],"firstAuthor":"Rogaeva Ekaterina","referenceYear":"2007"},{"lsid":"urn:lsid:swan.org:researchstatement:cbe25aeb-8139-4896-98af-c1b9eedeffba","title":"Toxic fibril hypothesis:  Beta-amyloid neurotoxicity requires fibril formation.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1994-12-06","id":"urn:lsid:swan.org:researchstatement:cbe25aeb-8139-4896-98af-c1b9eedeffba","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:cbe25aeb-8139-4896-98af-c1b9eedeffba&referrerLinkLabel=hypothesislist","label":"Lorenzo A et al.; Toxic fibril hypothesis:  Beta-amyloid n...","HotTopics":["Insoluble fibrillar Aβ leads to AD"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Yankner B A"],"firstAuthor":"Lorenzo A","taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"1994"},{"lsid":"urn:lsid:swan.org:researchstatement:1981d0a9-309a-4f2e-ab4e-4b3194e1be58","title":"An infectious pathogen may cause Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2000","id":"urn:lsid:swan.org:researchstatement:1981d0a9-309a-4f2e-ab4e-4b3194e1be58","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1981d0a9-309a-4f2e-ab4e-4b3194e1be58&referrerLinkLabel=hypothesislist","label":"Cochran G et al.; An infectious pathogen may cause Alzheim...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Ewald P W","Cochran K D"],"firstAuthor":"Cochran G M","taxonomy":["Oxidation"],"referenceYear":"2000"},{"lsid":"urn:lsid:swan.org:researchstatement:532b3f55-e367-4f48-9102-77c5ecc775cd","title":"Oxidative stress is a molecular link between β- and the γ-secretase activities, and provides a mechanistic explanation of the pathogenesis of sporadic late-onset Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2007-09","id":"urn:lsid:swan.org:researchstatement:532b3f55-e367-4f48-9102-77c5ecc775cd","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:532b3f55-e367-4f48-9102-77c5ecc775cd&referrerLinkLabel=hypothesislist","label":"Tabaton M et al.; Oxidative stress is a molecular link bet...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Tamagno E"],"firstAuthor":"Tabaton M","taxonomy":["Oxidation"],"referenceYear":"2007"},{"lsid":"urn:lsid:swan.org:researchstatement:b510d5da-856e-46fa-8be4-f8105e04e9b3","title":"Toxic Intracellular Aβ Hypothesis:  Intraneuronal Alzheimer Aβ42 accumulates in multivesicular bodies and is associated with synaptic pathology.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2002-11","id":"urn:lsid:swan.org:researchstatement:b510d5da-856e-46fa-8be4-f8105e04e9b3","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b510d5da-856e-46fa-8be4-f8105e04e9b3&referrerLinkLabel=hypothesislist","label":"Takahashi R et al.; Toxic Intracellular Aβ Hypothesis:  Intr...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Milner Teresa A","Li Feng","Nam Ellen E","Edgar Mark A","Yamaguchi Haruyasu","Beal M Flint","Xu Huaxi","Greengard Paul","Gouras Gunnar K"],"firstAuthor":"Takahashi Reisuke H","taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"2002"},{"lsid":"urn:lsid:swan.org:researchstatement:6603e668-820b-477d-99de-5ef03cf06f1c","title":"ApoE4 inhibits neurite outgrowth and may be directly involved in synaptic and neuritic maintenance in the normal and Alzheimer disease brain.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1995-10-10","id":"urn:lsid:swan.org:researchstatement:6603e668-820b-477d-99de-5ef03cf06f1c","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:6603e668-820b-477d-99de-5ef03cf06f1c&referrerLinkLabel=hypothesislist","label":"Holtzman D et al.; ApoE4 inhibits neurite outgrowth and may...","HotTopics":["Synaptic loss appears to be the most powerful and ubiquitous proximate factor leading to the dementia of Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Pitas R E","Kilbridge J","Nathan B","Mahley R W","Bu G","Schwartz A L"],"firstAuthor":"Holtzman D M","taxonomy":["ApoE"],"referenceYear":"1995"},{"lsid":"urn:lsid:swan.org:researchstatement:60039c86-364f-42e7-b0e1-03cf3883c4c2","title":"The generation of free radicals and oxidative stress plays a role in neurofibrillary pathogenesis of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1994-07","id":"urn:lsid:swan.org:researchstatement:60039c86-364f-42e7-b0e1-03cf3883c4c2","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:60039c86-364f-42e7-b0e1-03cf3883c4c2&referrerLinkLabel=hypothesislist","label":"Smith M et al.; The generation of free radicals and oxid...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Kutty R K","Richey P L","Yan S D","Stern D","Chader G J","Wiggert B","Petersen R B","Perry G"],"firstAuthor":"Smith M A","taxonomy":["Oxidation"],"referenceYear":"1994"},{"lsid":"urn:lsid:swan.org:researchstatement:fd055c1a-be40-42e3-bc93-d9f7127ba5a3","title":"A DNA polymorphism in the Angiotensin converting enzyme (ACE) gene has been linked to the risk for late onset Alzheimer Disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1999-12","id":"urn:lsid:swan.org:researchstatement:fd055c1a-be40-42e3-bc93-d9f7127ba5a3","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:fd055c1a-be40-42e3-bc93-d9f7127ba5a3&referrerLinkLabel=hypothesislist","label":"Alvarez R et al.; A DNA polymorphism in the Angiotensin co...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Genetic variants modulate risk of AD"],"otherAuthors":["Alvarez V","Lahoz C H","Martínez C","Peña J","Sánchez J M","Guisasola L M","Salas-Puig J","Morís G","Vidal J A","Ribacoba R","Menes B B","Uría D","Coto E"],"firstAuthor":"Alvarez R","referenceYear":"1999"},{"lsid":"urn:lsid:swan.org:researchstatement:14bbaa83-0f18-4003-8fce-6e73a7933bb9","title":"Cytoplasmic tail of APP forms transcriptionally active complex with Fe65 and histone acetyltransferase Tip60.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2001-07-06","id":"urn:lsid:swan.org:researchstatement:14bbaa83-0f18-4003-8fce-6e73a7933bb9","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:14bbaa83-0f18-4003-8fce-6e73a7933bb9&referrerLinkLabel=hypothesislist","label":"Cao X et al.; Cytoplasmic tail of APP forms transcript...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Südhof T C"],"firstAuthor":"Cao X","taxonomy":["Protein Processing"],"referenceYear":"2001"},{"lsid":"urn:lsid:swan.org:researchstatement:1860e14b-0a7a-40e3-a73f-478fe5c96b7a","title":"\"Fatal attractions\" between brain proteins are the key pathological events underlying Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2000","id":"urn:lsid:swan.org:researchstatement:1860e14b-0a7a-40e3-a73f-478fe5c96b7a","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1860e14b-0a7a-40e3-a73f-478fe5c96b7a&referrerLinkLabel=hypothesislist","label":"Trojanowski J et al.; \"Fatal attractions\" between brain protei...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Lee V M"],"firstAuthor":"Trojanowski J Q","taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"2000"},{"lsid":"urn:lsid:swan.org:researchstatement:1e787957-894d-4ff8-a6f0-7978010b7ea8","title":"Amyloid beta oligomers induce impairment of neuronal insulin receptors.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2008-01","id":"urn:lsid:swan.org:researchstatement:1e787957-894d-4ff8-a6f0-7978010b7ea8","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1e787957-894d-4ff8-a6f0-7978010b7ea8&referrerLinkLabel=hypothesislist","label":"Zhao W et al.; Amyloid beta oligomers induce impairment...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["De Felice Fernanda G","Fernandez Sara","Chen Hui","Lambert Mary P","Quon Michael J","Krafft Grant A","Klein William L"],"firstAuthor":"Zhao Wei-Qin","referenceYear":"2008"},{"lsid":"urn:lsid:swan.org:researchstatement:7a57a738-6d29-4dd6-bed4-42a704da4919","title":"Infiltration of the brain by pathogens causes Alzheimer's disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2004","id":"urn:lsid:swan.org:researchstatement:7a57a738-6d29-4dd6-bed4-42a704da4919","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:7a57a738-6d29-4dd6-bed4-42a704da4919&referrerLinkLabel=hypothesislist","label":"Itzhaki R et al.; Infiltration of the brain by pathogens c...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Wozniak M A","Appelt D M","Balin B J"],"firstAuthor":"Itzhaki R F","referenceYear":"2004"},{"lsid":"urn:lsid:swan.org:researchstatement:17e8ff8a-8a59-4ffd-b824-5a32dc71cfd1","title":"Microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1994-02","id":"urn:lsid:swan.org:researchstatement:17e8ff8a-8a59-4ffd-b824-5a32dc71cfd1","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:17e8ff8a-8a59-4ffd-b824-5a32dc71cfd1&referrerLinkLabel=hypothesislist","label":"Strittmatter W et al.; Microtubule instability and paired helic...","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Weisgraber K H","Goedert M","Saunders A M","Huang D","Corder E H","Dong L M","Jakes R","Alberts M J","Gilbert J R"],"firstAuthor":"Strittmatter W J","taxonomy":["ApoE"],"referenceYear":"1994"},{"lsid":"urn:lsid:swan.org:researchstatement:fd0a6dc4-e0cb-4f6c-8bce-2c437cb3c949","title":"Advanced Aging Plus \"Risk Factors\" May Explain Late-Onset Sporadic Alzheimer's Diease","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2000-06","id":"urn:lsid:swan.org:researchstatement:fd0a6dc4-e0cb-4f6c-8bce-2c437cb3c949","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:fd0a6dc4-e0cb-4f6c-8bce-2c437cb3c949&referrerLinkLabel=hypothesislist","label":"Chen  et al.; Advanced Aging Plus \"Risk Factors\" May E...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Fernandez"],"firstAuthor":"Chen","referenceYear":"2000"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a941dccb-b1b7-474b-ad3d-01a571beb52e\" title=\"Protein: TAR DNA-binding protein 43 [Homo sapiens]\">TAR DNA-binding protein 43<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d1b70427-57d3-4d6d-951d-9fc185717d9c\" title=\"Protein: Alpha-synuclein [Homo sapiens]\">Alpha-synuclein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:9b5b9f97-37e2-4a7c-8f17-e9c6addc3791\" title=\"Protein: High affinity interleukin-8 receptor B [Homo sapiens]\">High affinity interleukin-8 receptor B<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:2100b660-5c42-4cae-b136-313b82cfd794\" title=\"Protein: Interleukin-6 [Homo sapiens]\">Interleukin-6<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:329c18eb-cea1-41c5-a1bd-02d46ca95f6e\" title=\"Protein: Beta-galactosidase [Homo sapiens]\">Beta-galactosidase<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:30c02215-b98e-4f52-8cab-0a4b17372de9\" title=\"Protein: Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 [Homo sapiens]\">Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:4df78a0d-3593-4a77-8faa-f48b95425946\" title=\"Protein: Cellular tumor antigen p53 [Homo sapiens]\">Cellular tumor antigen p53<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e7d857db-5b82-453a-9aef-69ed8ae5e46b\" title=\"Protein: C-C motif chemokine 2 [Homo sapiens]\">C-C motif chemokine 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:65e819f9-1025-4f87-850b-bc8c01a95bd9\" title=\"Protein: Melanocyte protein Pmel 17 [Homo sapiens]\">Melanocyte protein Pmel 17<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a323ef41-9aa8-4473-8034-a1c99bd29af2\" title=\"Protein: Interleukin-8 [Homo sapiens]\">Interleukin-8<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6cb40b7f-192c-4ade-bf0f-8bd4dbebd4fe\" title=\"Protein: Neuroserpin [Homo sapiens]\">Neuroserpin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:7fe75218-5dff-4c9a-b409-640814331f95\" title=\"Protein: Superoxide dismutase [Cu-Zn] [Homo sapiens]\">Superoxide dismutase [Cu-Zn]<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e86a2aa0-acbc-4ae3-8eeb-bfe80c164114\" title=\"Protein: Huntingtin [Homo sapiens]\">Huntingtin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:2516dd10-fd7f-4c4b-b3a3-1850122abfe3\" title=\"Protein: Ataxin-1 [Homo sapiens]\">Ataxin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:251863cc-42c9-4254-9023-5cb6bdfe20ff\" title=\"Protein: Integral membrane protein 2B [Homo sapiens]\">Integral membrane protein 2B<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:edd7247c-3b62-4884-8ab1-dfeb0d582e1a&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:edd7247c-3b62-4884-8ab1-dfeb0d582e1a&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"The accumulation of misfolded protein aggregates can result in neurodegeneration.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:edd7247c-3b62-4884-8ab1-dfeb0d582e1a&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":1,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:edd7247c-3b62-4884-8ab1-dfeb0d582e1a&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:edd7247c-3b62-4884-8ab1-dfeb0d582e1a","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:edd7247c-3b62-4884-8ab1-dfeb0d582e1a&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Misfolded proteins accumulated into protein aggregates characterizes the pathologic lesions of Alzheimer Disease","Biomarkers are useful for predicting and staging Alzheimer disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":17,"containedwithoutevidence":6,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:edd7247c-3b62-4884-8ab1-dfeb0d582e1a&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:edd7247c-3b62-4884-8ab1-dfeb0d582e1a","containedwithevidence":77,"type":"Hypothesis","contained":83,"status":"Extended Annotation","referenceDate":"2009-10-12","containedevidencecount":190,"alternativeto":18,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:edd7247c-3b62-4884-8ab1-dfeb0d582e1a&referrerLinkLabel=hypothesislist","label":"Golde T et al.; The accumulation of misfolded protein ag...","otherAuthors":["Miller Victor M"],"firstAuthor":"Golde Todd E"},{"lsid":"urn:lsid:swan.org:researchstatement:f03ccec9-9db9-4531-83c2-43dd85b5924b","title":"TNF haplotype association with AD lends further support for an inflammatory process in the pathogenesis of AD.  ","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2000-12-04","id":"urn:lsid:swan.org:researchstatement:f03ccec9-9db9-4531-83c2-43dd85b5924b","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f03ccec9-9db9-4531-83c2-43dd85b5924b&referrerLinkLabel=hypothesislist","label":"Collins J et al.; TNF haplotype association with AD lends ...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Genetic variants modulate risk of AD"],"otherAuthors":["Perry Rodney T","Watson Bracie","Harrell  Lindy E","Acton Ronald T","Blacker Deborah","Albert Marilyn S","Tanzi Rudolph E","Bassett Susan S","McInnis M G","Campbell R Duncan","Go R C"],"firstAuthor":"Collins Julianne S","referenceYear":"2000"},{"lsid":"urn:lsid:swan.org:researchstatement:506ee43b-a9af-49cc-88a3-ee31c7108e75","title":"Cerebral Angiopathy Hypothesis of Alzheimer Disease: Neurofilament proteins are intrinsic components of amyloid plaque and affected blood vessels.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1981-11","id":"urn:lsid:swan.org:researchstatement:506ee43b-a9af-49cc-88a3-ee31c7108e75","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:506ee43b-a9af-49cc-88a3-ee31c7108e75&referrerLinkLabel=hypothesislist","label":"Powers J et al.; Cerebral Angiopathy Hypothesis of Alzhei...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Schlaepfer W W","Willingham M C","Hall B J"],"firstAuthor":"Powers J M","taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"1981"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:8d1bb864-d9ad-4f6d-85b0-c48f64bdb6b4\" title=\"Gene: Apoe apolipoprotein E [Mus musculus]\">Apoe<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:217e8ed5-5079-4e00-bf2a-beab8a5f7de4\" title=\"Protein: Apolipoprotein E [Mus musculus]\">Apolipoprotein E<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:178c8816-c8d6-4313-95f9-608e395b728a\" title=\"Gene: Sorl1 sortilin-related receptor, LDLR class A repeats-containing [Mus musculus]\">Sorl1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:b5b4975d-d965-4eec-8ab6-8a9de90366f0\" title=\"Gene: Ldlr low density lipoprotein receptor [Mus musculus]\">Ldlr<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d6f7964e-9435-4748-8719-7e25682de877\" title=\"Protein: Very low-density lipoprotein receptor [Mus musculus]\">Very low-density lipoprotein receptor<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f6c533c6-5dd3-4fa7-b719-358461e45414\" title=\"Protein: Low-density lipoprotein receptor precursor [Mus musculus]\">Low-density lipoprotein receptor precursor<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:0f1ea7bd-a76b-43bb-a6cb-a02e1ea5f6a6\" title=\"Gene: Vldlr very low density lipoprotein receptor [Mus musculus]\">Vldlr<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6ad3fdfc-2792-47ed-9fef-cc98db7fef9b\" title=\"Protein: Sortilin-related receptor [Mus musculus]\">Sortilin-related receptor<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e5bea4b8-fe13-40aa-8a5c-c7de3443a606&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e5bea4b8-fe13-40aa-8a5c-c7de3443a606&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"ApoE interacts with Aβ peptide, influences Aβ conformation and clearance in vivo.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e5bea4b8-fe13-40aa-8a5c-c7de3443a606&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":4,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e5bea4b8-fe13-40aa-8a5c-c7de3443a606&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:e5bea4b8-fe13-40aa-8a5c-c7de3443a606","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e5bea4b8-fe13-40aa-8a5c-c7de3443a606&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["ApoE contributes to Alzheimer Disease through multiple mechanisms","Defective mechanisms of Aβ clearance contribute to Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":27,"containedwithoutevidence":12,"taxonomy":["ApoE"],"referenceYear":"2001","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e5bea4b8-fe13-40aa-8a5c-c7de3443a606&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:e5bea4b8-fe13-40aa-8a5c-c7de3443a606","containedwithevidence":47,"type":"Hypothesis","contained":59,"status":"Extended Annotation","referenceDate":"2001-10","containedevidencecount":106,"alternativeto":10,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e5bea4b8-fe13-40aa-8a5c-c7de3443a606&referrerLinkLabel=hypothesislist","label":"Holtzman D; ApoE interacts with Aβ peptide, influenc...","firstAuthor":"Holtzman David M"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:c3811b05-b133-43fb-831f-cc0c0174d9f9\" title=\"Protein: Advanced glycosylation end product-specific receptor [Homo sapiens]\">Advanced glycosylation end product-specific receptor<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:dc39c47e-1e5c-4253-a762-9f9e558919fe\" title=\"Protein: Clusterin [Homo sapiens]\">Clusterin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:9449c4a8-ef5c-4082-bb7d-0b2a3e3972bb\" title=\"Protein: Proto-oncogene tyrosine-protein kinase Fyn [Homo sapiens]\">Proto-oncogene tyrosine-protein kinase Fyn<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:cfdaa5e5-f0e7-43f1-9347-558c2044dee8\" title=\"Gene: PSEN2 presenilin 2 (Alzheimer disease 4) [Homo sapiens]\">PSEN2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:c54768df-57f4-424a-a73a-2aeea9e4ba06\" title=\"Gene: AGER advanced glycosylation end product-specific receptor [Homo sapiens]\">AGER<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:aff3b9d4-767c-4eb3-863a-12d80b82b54a\" title=\"Gene: Fyn Fyn proto-oncogene [Mus musculus]\">Fyn<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:0be49a85-eebb-4909-bbcc-07b6d123b067\" title=\"Protein: Proto-oncogene tyrosine-protein kinase Fyn [Mus musculus]\">Proto-oncogene tyrosine-protein kinase Fyn<\/a>; ","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8d121de8-1573-4724-9dce-1aa1ac1ce5e6&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Diffusible, nonfibrillar ligands derived from Aβ42 are potent central nervous system neurotoxins.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8d121de8-1573-4724-9dce-1aa1ac1ce5e6&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8d121de8-1573-4724-9dce-1aa1ac1ce5e6&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:8d121de8-1573-4724-9dce-1aa1ac1ce5e6","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8d121de8-1573-4724-9dce-1aa1ac1ce5e6&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Soluble oligomeric aggregates of Aβ are toxic to neurons and cause AD pathology"],"supportedby":19,"containedwithoutevidence":1,"taxonomy":["Protein Aggregation and Deposition"],"referenceYear":"1998","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8d121de8-1573-4724-9dce-1aa1ac1ce5e6&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:8d121de8-1573-4724-9dce-1aa1ac1ce5e6","containedwithevidence":44,"type":"Hypothesis","contained":45,"status":"Extended Annotation","referenceDate":"1998-05-26","containedevidencecount":80,"alternativeto":12,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8d121de8-1573-4724-9dce-1aa1ac1ce5e6&referrerLinkLabel=hypothesislist","label":"Lambert M et al.; Diffusible, nonfibrillar ligands derived...","otherAuthors":["Barlow A K","Chromy B A","Edwards C","Freed R","Liosatos M","Morgan T E","Rozovsky I","Trommer B","Viola K L","Wals P","Zhang C","Finch C E","Krafft G A","Klein W L"],"firstAuthor":"Lambert M P"},{"lsid":"urn:lsid:swan.org:researchstatement:b37097b1-6781-4b00-b55b-5d488917fec6","title":"Loss of glutamatergic signalling in the hippocampus may be responsible for Alzheimer disease dementia.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1987-02","id":"urn:lsid:swan.org:researchstatement:b37097b1-6781-4b00-b55b-5d488917fec6","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:b37097b1-6781-4b00-b55b-5d488917fec6&referrerLinkLabel=hypothesislist","label":"Greenamyre J et al.; Loss of glutamatergic signalling in the ...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Penney J B","D'Amato C J","Young A B"],"firstAuthor":"Greenamyre J T","taxonomy":["Synapses"],"referenceYear":"1987"},{"lsid":"urn:lsid:swan.org:researchstatement:8aa82a20-9f6a-4f1f-9b47-059d34726de6","title":"Elevated serum and cortical neuron levels of Leuteinizing Hormone could play important roles in the pathogenesis of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2002-11-01","id":"urn:lsid:swan.org:researchstatement:8aa82a20-9f6a-4f1f-9b47-059d34726de6","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:8aa82a20-9f6a-4f1f-9b47-059d34726de6&referrerLinkLabel=hypothesislist","label":"Bowen R et al.; Elevated serum and cortical neuron level...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Smith Mark A","Harris Peggy L","Kubat Zvezdana","Martins Ralph N","Castellani Rudolph J","Perry George","Atwood Craig S"],"firstAuthor":"Bowen Richard L","taxonomy":["Hormones"],"referenceYear":"2002"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b0dbfee2-dca2-4e22-b3af-e1e92086bf65\" title=\"Protein: Prolow-density lipoprotein receptor-related protein 1 [Homo sapiens]\">Prolow-density lipoprotein receptor-related protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:c3811b05-b133-43fb-831f-cc0c0174d9f9\" title=\"Protein: Advanced glycosylation end product-specific receptor [Homo sapiens]\">Advanced glycosylation end product-specific receptor<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:beb73abe-e850-4182-998e-a7a847447b41\" title=\"Protein: Apolipoprotein E [Homo sapiens]\">Apolipoprotein E<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:060fc955-eddc-4988-bc63-30063734eec9\" title=\"Protein: Alpha-2-macroglobulin [Homo sapiens]\">Alpha-2-macroglobulin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:46a93973-ff08-4203-ae84-d50aeb4141b4\" title=\"Protein: Insulin-degrading enzyme [Homo sapiens]\">Insulin-degrading enzyme<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:5a7afb9f-0c7a-4d9e-9158-614ede751240\" title=\"Protein: Neprilysin [Homo sapiens]\">Neprilysin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:7501cc6e-9147-40cf-a277-db928f424295\" title=\"Protein: Insulin [Homo sapiens]\">Insulin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d00af273-bf32-4537-bf7c-59910e98fc6d\" title=\"Protein: Plasminogen [Homo sapiens]\">Plasminogen<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a3050a85-eacb-4d1a-b26e-2b6f1b6ce6ed\" title=\"Protein: Urokinase-type plasminogen activator [Homo sapiens]\">Urokinase-type plasminogen activator<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:eb032d1a-faca-4aba-997d-30a01a3e33f6\" title=\"Protein: Tissue-type plasminogen activator [Homo sapiens]\">Tissue-type plasminogen activator<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:dc39c47e-1e5c-4253-a762-9f9e558919fe\" title=\"Protein: Clusterin [Homo sapiens]\">Clusterin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:0b8bb41e-82d2-4490-8302-4d2c40995bda\" title=\"Protein: Neuropeptide Y [Homo sapiens]\">Neuropeptide Y<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e0da9931-d77c-423b-ae93-b65551b8f28f\" title=\"Gene: MME membrane metallo-endopeptidase [Homo sapiens]\">MME<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:3ce9f4a6-22d5-48c6-9b7d-4f2f1b090ad9\" title=\"Gene: LRP1 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) [Homo sapiens]\">LRP1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:0543626d-4bd2-4c74-b79d-3f39dd59a2f0\" title=\"Gene: A2M alpha-2-macroglobulin [Homo sapiens]\">A2M<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:62b16732-5468-4798-9565-249ed24183af\" title=\"Gene: IDE insulin-degrading enzyme [Homo sapiens]\">IDE<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:8ff22bfa-ebe5-4f9c-b8fa-12baf7e6b3a3\" title=\"Protein: Amyloid beta A4 protein [Mus musculus]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:968eee4c-9c87-4726-99d8-8d06d73f9069\" title=\"Gene: Ide insulin degrading enzyme [Mus musculus]\">Ide<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:843fba3d-b393-4a27-994c-693cb110ea29\" title=\"Protein: Prolow-density lipoprotein receptor-related protein 1 precursor [Mus musculus]\">Prolow-density lipoprotein receptor-related protein 1 precursor<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e2d65164-40ea-4cd6-8942-d925c7f02ba3\" title=\"Gene: Lrp1 low density lipoprotein receptor-related protein 1 [Mus musculus]\">Lrp1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f146913c-355e-4ba0-bca0-4e71409ff2e1\" title=\"Protein: Advanced glycosylation end product-specific receptor [Mus musculus]\">Advanced glycosylation end product-specific receptor<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:90602c00-8d81-48c6-a5c1-8d929394c903\" title=\"Protein: Insulin-degrading enzyme [Mus musculus]\">Insulin-degrading enzyme<\/a>; ","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:38fcef2f-d901-4261-b78b-36da30439e69&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Clearance of Aβ peptide is a critical event in Alzheimer Disease pathogenesis.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:38fcef2f-d901-4261-b78b-36da30439e69&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:38fcef2f-d901-4261-b78b-36da30439e69&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:38fcef2f-d901-4261-b78b-36da30439e69","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:38fcef2f-d901-4261-b78b-36da30439e69&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Defective mechanisms of Aβ clearance contribute to Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":10,"containedwithoutevidence":23,"referenceYear":"2004","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:38fcef2f-d901-4261-b78b-36da30439e69&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:38fcef2f-d901-4261-b78b-36da30439e69","containedwithevidence":36,"type":"Hypothesis","contained":59,"status":"Extended Annotation","referenceDate":"2004-09-02","containedevidencecount":40,"alternativeto":7,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:38fcef2f-d901-4261-b78b-36da30439e69&referrerLinkLabel=hypothesislist","label":"Tanzi R et al.; Clearance of Aβ peptide is a critical ev...","otherAuthors":["Moir Robert D","Wagner Steven L"],"firstAuthor":"Tanzi Rudolph E"},{"lsid":"urn:lsid:swan.org:researchstatement:1d5fa889-bdfd-4b78-9aa3-b6ad423e2567","title":"Endosomal-lysosomal disturbance is evident in neurons at risk to degenerate in Alzheimer disease brain.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1996-01","id":"urn:lsid:swan.org:researchstatement:1d5fa889-bdfd-4b78-9aa3-b6ad423e2567","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:1d5fa889-bdfd-4b78-9aa3-b6ad423e2567&referrerLinkLabel=hypothesislist","label":"Cataldo A et al.; Endosomal-lysosomal disturbance is evide...","HotTopics":["Cell membrane properties play a key role in AD Pathophysiology"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Hamilton D J","Barnett J L","Paskevich P A","Nixon R A"],"firstAuthor":"Cataldo A M","taxonomy":["Protein Degradation"],"referenceYear":"1996"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:c97485d8-7ae3-4313-8d36-6246cd9318ff\" title=\"Gene: CR1 complement component (3b/4b) receptor 1 (Knops blood group) [Homo sapiens]\">CR1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:d4e70f4a-d0fd-4c63-ac0e-16b07d929b28\" title=\"Gene: CLU clusterin [Homo sapiens]\">CLU<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:95fd1cff-b1a2-4d0d-9e71-317e9fd8f1de\" title=\"Gene: PICALM phosphatidylinositol binding clathrin assembly protein [Homo sapiens]\">PICALM<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>; ","containedwithevidence":8,"lsid":"urn:lsid:swan.org:researchstatement:d151a29c-99e7-4383-b336-600881561d34","title":"[ADNI] Genetic mutations might shift AD cognitive decline curve either away from or closer to the amyloid and neurodegenerative biomarker curves.","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d151a29c-99e7-4383-b336-600881561d34&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":8,"status":"Extended Annotation","id":"urn:lsid:swan.org:researchstatement:d151a29c-99e7-4383-b336-600881561d34","containedevidencecount":13,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d151a29c-99e7-4383-b336-600881561d34&referrerLinkLabel=hypothesislist","label":"Jack C et al.; [ADNI] Genetic mutations might shift AD ...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Biomarkers are useful for predicting and staging Alzheimer disease"],"otherAuthors":["Knopman David S","Jagust William J","Shaw Leslie M","Aisen Paul S","Weiner M","Petersen Ronald C","Trojanowski John Q"],"containedwithoutevidence":0,"firstAuthor":"Jack Clifford R","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:d151a29c-99e7-4383-b336-600881561d34&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:f57fafea-bcbd-49c7-9651-6d6740dd939e&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:f57fafea-bcbd-49c7-9651-6d6740dd939e","type":"Hypothesis","title":"Hypertension and the expression of an innate pro-inflammatory cytokine profile in middle age are early risk factors of AD in old age.","label":"Hypertension and the expression of an in...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","status":"Simple Annotation","id":"urn:lsid:swan.org:researchstatement:f57fafea-bcbd-49c7-9651-6d6740dd939e"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c0a13dd-8db3-4051-b94c-5f2b3e7c6df1\" title=\"Protein: Presenilin-1 [Homo sapiens]\">Presenilin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:49ffd23c-235c-4ebe-b571-fa09f1414cb2\" title=\"Protein: Beta-secretase 1 [Homo sapiens]\">Beta-secretase 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:711b1199-6433-458a-910e-1cd83d4c1420\" title=\"Protein: 2',3'-cyclic-nucleotide 3'-phosphodiesterase [Homo sapiens]\">2',3'-cyclic-nucleotide 3'-phosphodiesterase<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:746b6ca5-a904-49d9-a2b7-8288af535125\" title=\"Gene: APP amyloid beta (A4) precursor protein [Homo sapiens]\">APP<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:82a7ca2e-d848-4a24-b189-8ab3be94d56d\" title=\"Protein: Pro-neuregulin-1, membrane-bound isoform [Homo sapiens]\">Pro-neuregulin-1, membrane-bound isoform<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:c491d384-2b36-4766-ab34-f99af28daf72\" title=\"Protein: Granulins [Homo sapiens]\">Granulins<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a941dccb-b1b7-474b-ad3d-01a571beb52e\" title=\"Protein: TAR DNA-binding protein 43 [Homo sapiens]\">TAR DNA-binding protein 43<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c7d5761-276f-4fd4-bddf-63397612869f\" title=\"Protein: Myelin proteolipid protein [Homo sapiens]\">Myelin proteolipid protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d1b70427-57d3-4d6d-951d-9fc185717d9c\" title=\"Protein: Alpha-synuclein [Homo sapiens]\">Alpha-synuclein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:772ce683-db38-4093-8da4-89141e8768ae\" title=\"Protein: Cell division protein kinase 5 [Homo sapiens]\">Cell division protein kinase 5<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b4f3109c-0624-4096-be2d-b75fd6598c31\" title=\"Protein: Glycogen synthase kinase-3 beta [Homo sapiens]\">Glycogen synthase kinase-3 beta<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:57018c9b-f2ce-4266-af3f-56b105c84dc6\" title=\"Protein: Serotransferrin [Homo sapiens]\">Serotransferrin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:5acb5e00-64bb-4892-b835-c61efe93af57\" title=\"Protein: Ferritin light chain [Homo sapiens]\">Ferritin light chain<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:7f43bd9d-d0ac-4ac6-b7c7-57332c9eccae\" title=\"Protein: Myelin basic protein [Homo sapiens]\">Myelin basic protein<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:6365bece-ad2b-4df3-94fd-99a9ec8616d0\" title=\"Gene: Mag myelin-associated glycoprotein [Mus musculus]\">Mag<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:11d11f79-ecdc-4517-a068-c99b890f94ea\" title=\"Gene: Plp1 proteolipid protein (myelin) 1 [Mus musculus]\">Plp1<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bbdc006c-b5ee-412e-b539-ce73fb69c171&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"The human brain\u2019s myelin sheaths underlie a unique vulnerability to Alzheimer Disease (AD).","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bbdc006c-b5ee-412e-b539-ce73fb69c171&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":1,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bbdc006c-b5ee-412e-b539-ce73fb69c171&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:bbdc006c-b5ee-412e-b539-ce73fb69c171","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bbdc006c-b5ee-412e-b539-ce73fb69c171&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Cell membrane properties play a key role in AD Pathophysiology"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":9,"containedwithoutevidence":0,"referenceYear":"2009","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bbdc006c-b5ee-412e-b539-ce73fb69c171&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:bbdc006c-b5ee-412e-b539-ce73fb69c171","containedwithevidence":42,"type":"Hypothesis","contained":42,"status":"Extended Annotation","referenceDate":"2009-09-21","containedevidencecount":170,"alternativeto":10,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:bbdc006c-b5ee-412e-b539-ce73fb69c171&referrerLinkLabel=hypothesislist","label":"Bartzokis G; The human brain\u2019s myelin sheaths underli...","firstAuthor":"Bartzokis George"},{"lsid":"urn:lsid:swan.org:researchstatement:26b77415-58c9-4fdb-bc99-8e141814e005","title":"Cholesterol 25-Hydroxylase on Chromosome 10q is a susceptibility gene for sporadic AD.  ","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2005","id":"urn:lsid:swan.org:researchstatement:26b77415-58c9-4fdb-bc99-8e141814e005","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:26b77415-58c9-4fdb-bc99-8e141814e005&referrerLinkLabel=hypothesislist","label":"Papassotiropoulos A et al.; Cholesterol 25-Hydroxylase on Chromosome...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Genetic variants modulate risk of AD"],"otherAuthors":["Lambert Jean-Charles","Wavrant De-Vrieze Fabienne","Wollmer M Axel","von der Kammer Heinz","Streffer Johannes R","Maddalena Alessia","Huynh Kim-Dung","Wolleb Sibylle","Lutjohann D","Schneider Brigitte","Thal Dietmar","Grimaldi Luigi  M. E.","Tsolaki Magdalini","Kapaki Elisabeth","Ravid Rivka","Konietzko Uwe","Hegi Thomas","Pasch  Thomas","Jung Hans","Braak Heiko","Amouyel Philippe","Rogaev E I","Hardy John","Hock Christoph","Nitsch Roger M"],"firstAuthor":"Papassotiropoulos Andreas","referenceYear":"2005"},{"lsid":"urn:lsid:swan.org:researchstatement:36cee867-51a4-4622-8d47-65c3a0421f83","title":"Metal toxicity: Copper homeostasis is an important factor in the pathological progression of Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1999-09-25","id":"urn:lsid:swan.org:researchstatement:36cee867-51a4-4622-8d47-65c3a0421f83","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:36cee867-51a4-4622-8d47-65c3a0421f83&referrerLinkLabel=hypothesislist","label":"White A et al.; Metal toxicity: Copper homeostasis is an...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Reyes R","Mercer J F","Camakaris J","Zheng H","Bush A I","Multhaup G","Beyreuther K","Masters C L","Cappai R"],"firstAuthor":"White A R","taxonomy":["Oxidation"],"referenceYear":"1999"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:607f4fa6-5204-44ac-81c5-b3957f9f2855\" title=\"Gene: MAPT microtubule-associated protein tau [Homo sapiens]\">MAPT<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:877a0d20-8709-4c2d-a1a8-fb1873be3124\" title=\"Protein: Catenin beta-1 [Homo sapiens]\">Catenin beta-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:b4f3109c-0624-4096-be2d-b75fd6598c31\" title=\"Protein: Glycogen synthase kinase-3 beta [Homo sapiens]\">Glycogen synthase kinase-3 beta<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:d9eabd34-fdc9-4da4-8240-31a71f8852dc\" title=\"Protein: Proto-oncogene protein Wnt-1 [Homo sapiens]\">Proto-oncogene protein Wnt-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:71d4923f-2515-48c4-8c49-67c7222a3239\" title=\"Protein: Glycogen synthase kinase-3 alpha [Homo sapiens]\">Glycogen synthase kinase-3 alpha<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:48fcf978-d7c7-459a-a2a3-82dce706de98\" title=\"Gene: PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 [Homo sapiens]\">PDHA1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3777def7-0668-4962-8b87-66665b2911b9\" title=\"Protein: Amyloid beta A4 protein [Homo sapiens]\">Amyloid beta A4 protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:554dc1ed-6bea-471e-b45f-54c64c0ebb0d\" title=\"Protein: Adenomatous polyposis coli protein [Homo sapiens]\">Adenomatous polyposis coli protein<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:a9f86219-7376-43bf-995b-2d34a716b10b\" title=\"Protein: Cyclic AMP-responsive element-binding protein 1 [Homo sapiens]\">Cyclic AMP-responsive element-binding protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:9449c4a8-ef5c-4082-bb7d-0b2a3e3972bb\" title=\"Protein: Proto-oncogene tyrosine-protein kinase Fyn [Homo sapiens]\">Proto-oncogene tyrosine-protein kinase Fyn<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:7501cc6e-9147-40cf-a277-db928f424295\" title=\"Protein: Insulin [Homo sapiens]\">Insulin<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:4f4566aa-0a8c-4acb-abdd-4281fa362c3a\" title=\"Gene: GSK3A glycogen synthase kinase 3 alpha [Homo sapiens]\">GSK3A<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:c9b06bab-c14c-4b73-b207-dda49f3a5939\" title=\"Gene: GSK3B glycogen synthase kinase 3 beta [Homo sapiens]\">GSK3B<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:46a93973-ff08-4203-ae84-d50aeb4141b4\" title=\"Protein: Insulin-degrading enzyme [Homo sapiens]\">Insulin-degrading enzyme<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:32d3fca2-ca67-4c01-a873-f1887ae60d08\" title=\"Gene: LRP6 low density lipoprotein receptor-related protein 6 [Homo sapiens]\">LRP6<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e950cf0f-6253-485e-979f-49f2ba6fab99\" title=\"Gene: APOE apolipoprotein E [Homo sapiens]\">APOE<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:506cf24f-9182-4974-9a6e-380df365b90f\" title=\"Gene: DKK1 dickkopf homolog 1 (Xenopus laevis) [Homo sapiens]\">DKK1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:60f8116f-068a-48fd-88bf-92915c626dbb\" title=\"Gene: PSEN1 presenilin 1 [Homo sapiens]\">PSEN1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:c56b0c7c-e4ca-442f-be78-8f3a3e6b4d13\" title=\"Protein: Translation initiation factor eIF-2B subunit beta [Homo sapiens]\">Translation initiation factor eIF-2B subunit beta<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:309f72a1-7834-460c-acc5-139dce12d5a4\" title=\"Protein: Glycogen [starch] synthase, muscle [Homo sapiens]\">Glycogen [starch] synthase, muscle<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:502fda3e-c2b1-47c4-a1fa-dc0c0941dc5b\" title=\"Protein: Translation initiation factor eIF-2B subunit epsilon [Homo sapiens]\">Translation initiation factor eIF-2B subunit epsilon<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:ca7c9231-1564-4550-8492-f3076b0b9060\" title=\"Protein: Translation initiation factor eIF-2B subunit gamma [Homo sapiens]\">Translation initiation factor eIF-2B subunit gamma<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:92d83dc1-35e3-46ce-b14d-e14b1fa19a2e\" title=\"Protein: Translation initiation factor eIF-2B subunit delta [Homo sapiens]\">Translation initiation factor eIF-2B subunit delta<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f2bea597-f098-4d6f-a14e-a4ac0df191cf\" title=\"Protein: Translation initiation factor eIF-2B subunit alpha [Homo sapiens]\">Translation initiation factor eIF-2B subunit alpha<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:8f4d5729-851b-464f-97b7-a4c7e390dc81\" title=\"Protein: Ribosomal protein S6 kinase beta-1 [Homo sapiens]\">Ribosomal protein S6 kinase beta-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:7de5f829-651e-4d00-99b0-c2491ee9dc81\" title=\"Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) [Homo sapiens]\">PCK1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:3d8b33c4-6504-408b-bab3-ab45a7dd2bc0\" title=\"Gene: PPARG peroxisome proliferator-activated receptor gamma [Homo sapiens]\">PPARG<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:2ba06a20-f60c-498c-86e4-9d8f2ed1e7df\" title=\"Gene: GAB2 GRB2-associated binding protein 2 [Homo sapiens]\">GAB2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:e646582c-e916-4094-b0be-d99d9868ff53\" title=\"Gene: SOS2 son of sevenless homolog 2 (Drosophila) [Homo sapiens]\">SOS2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6c3fd71b-6a13-4a70-9644-a52cef750933\" title=\"Protein: Dihydropyrimidinase-related protein 2 [Homo sapiens]\">Dihydropyrimidinase-related protein 2<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:020adcc4-7aaf-4e71-bdbf-5f82541d0bfc\" title=\"Protein: Dihydropyrimidinase-related protein 3 [Homo sapiens]\">Dihydropyrimidinase-related protein 3<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:43f877cf-3402-45b8-9d4c-9c4b5520bae0\" title=\"Protein: Dihydropyrimidinase-related protein 5 [Homo sapiens]\">Dihydropyrimidinase-related protein 5<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:6e708cf4-17aa-401d-a11b-e66c2243934a\" title=\"Protein: Dihydropyrimidinase-related protein 1 [Homo sapiens]\">Dihydropyrimidinase-related protein 1<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=7227\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Drosophila melanogaster<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:18bd6962-0cb2-45a1-8228-7da432059862\" title=\"Gene: l(1)3Ba shaggy [Drosophila melanogaster]\">l(1)3Ba<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Mus musculus<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:9a8d5756-fc0c-4d88-9d7a-7baff29f6e3a\" title=\"Protein: Catenin beta-1 [Mus musculus]\">Catenin beta-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:3868fb7d-04bd-4acd-8d0f-f0127f424816\" title=\"Protein: Proto-oncogene protein Wnt-1 [Mus musculus]\">Proto-oncogene protein Wnt-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:81c45ac5-97d8-4897-a5b5-e1ebbaf0183f\" title=\"Protein: Glycogen synthase kinase-3 beta [Mus musculus]\">Glycogen synthase kinase-3 beta<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:796cc037-1f13-4bf4-9678-b9f5ab6ecf69\" title=\"Protein: Glycogen synthase kinase-3 alpha [Mus musculus]\">Glycogen synthase kinase-3 alpha<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:ad36ea14-a29b-4361-b128-d7dfdcba37d8\" title=\"Protein: Cyclic AMP-responsive element-binding protein 1 [Mus musculus]\">Cyclic AMP-responsive element-binding protein 1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:751129bb-2878-4a16-8db5-a8823e8cad5c\" title=\"Protein: Insulin-1 [Mus musculus]\">Insulin-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:88a619fe-2ef6-4239-869c-26ab9254a96d\" title=\"Gene: Gsk3b glycogen synthase kinase 3 beta [Mus musculus]\">Gsk3b<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:b314d3e6-4dd5-4709-9cb7-1c7f452eb635\" title=\"Gene: Gsk3a glycogen synthase kinase 3 alpha [Mus musculus]\">Gsk3a<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:c005ef0f-dabf-4fa2-8a84-32e6758baca7\" title=\"Protein: Glycogen [starch] synthase, muscle [Mus musculus]\">Glycogen [starch] synthase, muscle<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:72494b53-52b1-4135-a2a2-cee6e24a834f\" title=\"Protein: Translation initiation factor eIF-2B subunit epsilon [Mus musculus]\">Translation initiation factor eIF-2B subunit epsilon<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:00eda23c-4bcd-42dc-b63f-fbc401877bbd\" title=\"Protein: Translation initiation factor eIF-2B subunit alpha [Mus musculus]\">Translation initiation factor eIF-2B subunit alpha<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:8b62a766-ef1f-4b8d-9598-d54c810073f9\" title=\"Protein: Translation initiation factor eIF-2B subunit beta [Mus musculus]\">Translation initiation factor eIF-2B subunit beta<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:8ee1866f-b293-4a5a-8b6b-1366610f7ea2\" title=\"Protein: Translation initiation factor eIF-2B subunit delta [Mus musculus]\">Translation initiation factor eIF-2B subunit delta<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:99ed178e-0c02-412e-99f9-ccf5f636ab7b\" title=\"Protein: Ribosomal protein S6 kinase beta-1 [Mus musculus]\">Ribosomal protein S6 kinase beta-1<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e02dc3a7-d334-4ba4-9474-5dadce8ca9f6\" title=\"Protein: Microtubule-associated protein tau [Mus musculus]\">Microtubule-associated protein tau<\/a>; [<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=8355\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Xenopus laevis<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:gene:9d54a422-888e-4a9d-801a-f0c30f281d5f\" title=\"Gene: xgsk-3 intracellular kinase [Xenopus laevis]\">xgsk-3<\/a>; ","relatedToOthers":"true","title":"GSK3 is a causal mediator of Alzheimer disease.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:62641fb7-a346-444d-af7c-519eafc68936&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:62641fb7-a346-444d-af7c-519eafc68936&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:62641fb7-a346-444d-af7c-519eafc68936","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:62641fb7-a346-444d-af7c-519eafc68936&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Signaling mechanisms play a critical role in Alzheimer Disease"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":11,"containedwithoutevidence":0,"referenceYear":"2008","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:62641fb7-a346-444d-af7c-519eafc68936&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:62641fb7-a346-444d-af7c-519eafc68936","containedwithevidence":45,"type":"Hypothesis","contained":45,"status":"Extended Annotation","referenceDate":"2008-03","containedevidencecount":84,"alternativeto":5,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:62641fb7-a346-444d-af7c-519eafc68936&referrerLinkLabel=hypothesislist","label":"Hooper C et al.; GSK3 is a causal mediator of Alzheimer d...","otherAuthors":["Killick Richard","Lovestone Simon"],"firstAuthor":"Hooper Claudie"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:f72ce13c-8e50-47de-a1c8-9e056cfe5f4b\" title=\"Protein: Microtubule-associated protein tau [Homo sapiens]\">Microtubule-associated protein tau<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:326b1f1b-ef20-49ee-bb20-99a15329fafb\" title=\"Protein: Beta-amyloid protein 40 [Homo sapiens]\">Beta-amyloid protein 40<\/a>, <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>; ","containedwithevidence":10,"lsid":"urn:lsid:swan.org:researchstatement:e8c6a556-53d5-4372-a350-9feaca81ec4a","title":"[ADNI]  Structural magnetic resonance imaging (MRI) measurement of cerebral atrophy accompanies cognitive decline in MCI and AD.","type":"Hypothesis","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e8c6a556-53d5-4372-a350-9feaca81ec4a&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","contained":10,"status":"Extended Annotation","id":"urn:lsid:swan.org:researchstatement:e8c6a556-53d5-4372-a350-9feaca81ec4a","containedevidencecount":25,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e8c6a556-53d5-4372-a350-9feaca81ec4a&referrerLinkLabel=hypothesislist","label":"Jack C et al.; [ADNI]  Structural magnetic resonance im...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Biomarkers are useful for predicting and staging Alzheimer disease"],"otherAuthors":["Knopman David S","Jagust William J","Shaw Leslie M","Aisen Paul S","Weiner M","Petersen Ronald C","Trojanowski John Q"],"containedwithoutevidence":0,"firstAuthor":"Jack Clifford R","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:e8c6a556-53d5-4372-a350-9feaca81ec4a&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist"},{"lsid":"urn:lsid:swan.org:researchstatement:99243a11-fd49-4da5-8a22-b58919cd6865","title":"Plasticity of receptors in hippocampus correlates with Alzheimer disease pathology.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1986-09","id":"urn:lsid:swan.org:researchstatement:99243a11-fd49-4da5-8a22-b58919cd6865","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:99243a11-fd49-4da5-8a22-b58919cd6865&referrerLinkLabel=hypothesislist","label":"Geddes J et al.; Plasticity of receptors in hippocampus c...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Cotman Carl W"],"firstAuthor":"Geddes J W","referenceYear":"1986"},{"lsid":"urn:lsid:swan.org:researchstatement:dd03ba61-a797-4afd-884a-810267faf1e0","title":"Multimerization of APP by Aβ contributes to neurotoxicity.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2003-12","id":"urn:lsid:swan.org:researchstatement:dd03ba61-a797-4afd-884a-810267faf1e0","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:dd03ba61-a797-4afd-884a-810267faf1e0&referrerLinkLabel=hypothesislist","label":"Lu D et al.; Multimerization of APP by Aβ contributes...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":["Soluble oligomeric aggregates of Aβ are toxic to neurons and cause AD pathology"],"otherAuthors":["Shaked Gideon M","Bredesen Dale E","Masliah Eliezer","Koo Edward H"],"firstAuthor":"Lu Daniel C","referenceYear":"2003"},{"lsid":"urn:lsid:swan.org:researchstatement:36f702d8-de14-433d-bce5-7e92d434716d","title":"NMDA receptor dysfunction and Alzheimer's disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1998","id":"urn:lsid:swan.org:researchstatement:36f702d8-de14-433d-bce5-7e92d434716d","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:36f702d8-de14-433d-bce5-7e92d434716d&referrerLinkLabel=hypothesislist","label":"Olney J et al.; NMDA receptor dysfunction and Alzheimer'...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Wozniak D F","Farber N B"],"firstAuthor":"Olney J W","referenceYear":"1998"},{"lsid":"urn:lsid:swan.org:researchstatement:829414a6-af37-424a-a434-6a514272d9b7","title":"The degenerative process of Alzheimer disease involves a differential vulnerability of specific neuronal subsets expressing Calbindin.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"1991-03","id":"urn:lsid:swan.org:researchstatement:829414a6-af37-424a-a434-6a514272d9b7","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:829414a6-af37-424a-a434-6a514272d9b7&referrerLinkLabel=hypothesislist","label":"Hof P et al.; The degenerative process of Alzheimer di...","HotTopics":["Changes in calcium homeostasis may provide a common pathway for the neuropathological changes in AD"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Morrison J H"],"firstAuthor":"Hof P R","taxonomy":["Synapses"],"referenceYear":"1991"},{"lsescontent":"[<a href=\"http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606\" style=\"display: inline; white-space: nowrap;\" target=\"_blank\"><img src=\"/swan/images/browser/externalLink.gif\" border=\"0\">Homo sapiens<\/a>]: <a href=\"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:protein:e8649637-cd88-425d-8742-a36de9734104\" title=\"Protein: Beta-amyloid protein 42 [Homo sapiens]\">Beta-amyloid protein 42<\/a>; ","refutedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:41f6e8e6-bbc5-4aaf-885b-62b9e1fd669b&selectContainedDiscourseElementCriteria=hasRefutesOrRefutedByDiscourseElements&referrerLinkLabel=hypothesislist","containedwithoutevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:41f6e8e6-bbc5-4aaf-885b-62b9e1fd669b&selectContainedDiscourseElementCriteria=hasNoEvidence&referrerLinkLabel=hypothesislist","relatedToOthers":"true","title":"Plaque removal is not enough to halt progressive neurodegeneration in Alzheimer Disease.","containedevidencecountlink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:41f6e8e6-bbc5-4aaf-885b-62b9e1fd669b&selectContainedDiscourseElementCriteria=hasTotalEvidence&referrerLinkLabel=hypothesislist","refutedby":1,"alternativetolink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:41f6e8e6-bbc5-4aaf-885b-62b9e1fd669b&selectContainedDiscourseElementCriteria=alternativeToOtherDiscourseElements&referrerLinkLabel=hypothesislist","id":"urn:lsid:swan.org:researchstatement:41f6e8e6-bbc5-4aaf-885b-62b9e1fd669b","supportedbylink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:41f6e8e6-bbc5-4aaf-885b-62b9e1fd669b&selectContainedDiscourseElementCriteria=hasSupportOrSupportedByDiscourseElements&referrerLinkLabel=hypothesislist","HotTopics":["Aβ accumulation in the brain is the primary event in Alzheimer Disease pathogenesis","Insoluble fibrillar Aβ leads to AD"],"icon":"../icons/ontological/discourse-element/h-research-statement.png","supportedby":9,"containedwithoutevidence":1,"referenceYear":"2008","lses":"true","containedwithevidencelink":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:41f6e8e6-bbc5-4aaf-885b-62b9e1fd669b&selectContainedDiscourseElementCriteria=hasEvidence&referrerLinkLabel=hypothesislist","lsid":"urn:lsid:swan.org:researchstatement:41f6e8e6-bbc5-4aaf-885b-62b9e1fd669b","containedwithevidence":32,"type":"Hypothesis","contained":33,"status":"Extended Annotation","referenceDate":"2008-07-19","containedevidencecount":56,"alternativeto":5,"lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:41f6e8e6-bbc5-4aaf-885b-62b9e1fd669b&referrerLinkLabel=hypothesislist","label":"Holmes C et al.; Plaque removal is not enough to halt pro...","otherAuthors":["Boche Delphine","Wilkinson David","Yadegarfar Ghasem","Hopkins Vivienne","Bayer Anthony","Jones Roy W","Bullock Roger","Love Seth","Neal James W","Zotova Elina","Nicoll James A"],"firstAuthor":"Holmes Clive"},{"lsid":"urn:lsid:swan.org:researchstatement:9c8f822f-6088-4d78-828e-f857212bbd42","title":"Macroautophagy is a novel A&#946;-generating pathway that is activated early in Alzheimer disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2005-10-10","id":"urn:lsid:swan.org:researchstatement:9c8f822f-6088-4d78-828e-f857212bbd42","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:9c8f822f-6088-4d78-828e-f857212bbd42&referrerLinkLabel=hypothesislist","label":"Yu W et al.; Macroautophagy is a novel A&#946;-genera...","HotTopics":"Unclassified","icon":"../icons/ontological/discourse-element/h-research-statement.png","otherAuthors":["Cuervo Ana Maria","Kumar Asok","Peterhoff Corrinne M","Schmidt Stephen D","Lee Ju-Hyun","Mohan Panaiyur S","Mercken Marc","Farmery Mark R","Tjernberg Lars O","Jiang Ying","Duff Karen","Uchiyama Yasuo","Näslund Jan","Mathews Paul M","Cataldo Anne M","Nixon Ralph A"],"firstAuthor":"Yu W Haung","taxonomy":["Protein Degradation"],"referenceYear":"2005"},{"lsid":"urn:lsid:swan.org:researchstatement:a6469733-1ec4-4db2-8c90-18f13cd1b7a1","title":"The cause of neuronal pathology in Alzheimer's disease.","type":"Hypothesis","status":"Simple Annotation","referenceDate":"2000-02","id":"urn:lsid:swan.org:researchstatement:a6469733-1ec4-4db2-8c90-18f13cd1b7a1","lsidUrl":"/swan/browser/showEntity.action?objectId=urn:lsid:swan.org:researchstatement:a6469733-1ec4-4db2-8c90-18f13cd1b7a1&referrerLinkLabel=hypothesislist","label":"Vickers J et al.; The cause of neuronal pathology in Alzhe...","icon":"../icons/ontological/discourse-element/h-research-statement.png","HotTopics":"Unclassified","otherAuthors":["Dickson T C","Adlard P A","Saunders H L","King C E","McCormack G"],"firstAuthor":"Vickers J 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